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OtherCARDIOVASCULAR PHARMACOLOGY

Carvedilol Retards Sudden Loss of Contraction during Early Regional Myocardial Ischemia in Feline Hearts

Harald Brunv and and Ketil Grong
Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 363-368;
Harald Brunv
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Abstract

The purpose of our study was to investigate whether loss of myocardial contraction immediately after coronary occlusion was nonuniform, and if pretreatment with carvedilol, a vasodilating nonselective β-adrenoceptor antagonist, could retard loss of contraction after coronary artery occlusion. Feline hearts were subjected to acute regional ischemia by total occlusion of the left anterior descending coronary artery. The animals were either treated with vehicle (control group) or with carvedilol 1 mg/kg i.v. before left anterior descending coronary artery occlusion (n = 9 in each group). Regional contraction in the left anterior descending coronary artery perfused region of the heart was studied by cross-oriented sonomicrometry. In control animals, circumferential (subepicardial) contraction ceased after 10 sec, whereas longitudinal (subendocardial) contraction ceased immediately after left anterior descending coronary artery occlusion. Loss of contraction in animals treated with carvedilol was significantly slower compared to controls. Circumferential contraction ceased between 30 sec and 1 min, whereas longitudinal contraction ceased after 20 sec. In conclusion, loss of contraction during the first seconds after coronary occlusion was nonuniform, with most rapid dysfunction in the subendocardium. Pretreatment with carvedilol retarded loss of contraction in both axes.

Footnotes

  • Send reprint requests to: Dr. Harald Brunvand, Surgical Research Laboratory, Haukeland University Hospital, 5021 Bergen, Norway.

  • ↵1 This study was made possible by a research fellowship from the Norwegian Council for Cardiovascular Diseases and supported by grants from the Laerdal Foundation for Acute Medicine, the Norwegian Air Ambulance Foundation, the Bergen Heart Foundation and the Riisøens Foundation.

  • Abbreviations:
    LAD
    left anterior descending coronary artery
    EDL
    end diastolic length
    ESL
    end systolic length
    LVSP
    left ventricular systolic pressure
    LVEDP
    left ventricular end diastolic pressure
    RPP
    rate pressure product
    • Received September 13, 1996.
    • Accepted March 27, 1997.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics
Vol. 282, Issue 1
1 Jul 1997
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OtherCARDIOVASCULAR PHARMACOLOGY

Carvedilol Retards Sudden Loss of Contraction during Early Regional Myocardial Ischemia in Feline Hearts

Harald Brunv and and Ketil Grong
Journal of Pharmacology and Experimental Therapeutics July 1, 1997, 282 (1) 363-368;

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OtherCARDIOVASCULAR PHARMACOLOGY

Carvedilol Retards Sudden Loss of Contraction during Early Regional Myocardial Ischemia in Feline Hearts

Harald Brunv and and Ketil Grong
Journal of Pharmacology and Experimental Therapeutics July 1, 1997, 282 (1) 363-368;
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