Journal of Pharmacology and Experimental Therapeutics: 282 (1)

July 01, 1997; Volume 282,Issue 1

ANALGESIA AND DRUGS OF ABUSE

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Enhancement of Analgesia from Systemic Opioid in Humans by Spinal Cholinesterase Inhibition
David D. Hood, Kathryn A. Mallak, Robert L. James, Robin Tuttle and James C. Eisenach

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 86-92;
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Antagonistic Modulation Between the Delta Opioid Agonist BW373U86 and the Mu Opioid Agonist Fentanyl in Mice
Scott J. O’Neill, Mark A. Collins, Hugh O. Pettit, Robert W. McNutt and Kwen-Jen Chang

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 271-277;
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EEG Spectral Analysis of the Neuroprotective KappaOpioids Enadoline and PD117302
Frank C. Tortella, Jany Rose, Lydia Robles, J. Edward Moreton, John Hughes and John C. Hunter

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 286-293;
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Antinociceptive Profile of 3-α-tropanyl-(2-Cl)-acid phenoxybutyrate (SM-21): A Novel Analgesic with a Presynaptic Cholinergic Mechanism of Action
Carla Ghelardini, Nicoletta Galeotti, Fulvio Gualtieri, Cristina Bellucci, Dina Manetti, Alberto Giotti, Petra Malmberg-Aiello, Alessandro Galli and Alessandro Bartolini

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 430-439;

AUTONOMIC PHARMACOLOGY

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An Analysis of the Mechanisms Involved in the Okadaic Acid-Induced Contraction of the Estrogen-Primed Rat Uterus
Elena Arteche, Giuseppe Strippoli, Gervaise Loirand, Pierre Pacaud, Luz Candenas, Juan-Carlos Moltó, Luisa Souto, Javier Fernandez, Manuel Norte, Julio D. Martín and Jean-Pierre Savineau

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 201-207;
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Comparative Alpha-1 Adrenoceptor Subtype Selectivity and Functional Uroselectivity of Alpha-1 Adrenoceptor Antagonists
D. J. Martin, P. Lluel, E. Guillot, A. Coste, D. Jammes and I. Angel

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 228-235;
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Activation of Alpha-2 Adrenergic Receptors Inhibits Norepinephrine Release by a Pertussis Toxin-Insensitive Pathway Independent of Changes in Cytosolic Calcium in Cultured Rat Sympathetic Neurons
Dean D. Schwartz

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 248-255;
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Three Allosteric Modulators Act at a Common Site, Distinct from that of Competitive Antagonists, at Muscarinic Acetylcholine M₂ Receptors
Alfred Lanzafame, Arthur Christopoulos and Fred Mitchelson

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 278-285;
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Adenosine 3′,5′-Cyclic Monophosphate-Stimulated Ca⁺⁺Efflux and Acetylcholine Release in Ileal Myenteric Plexus Are Mediated by N-Type Ca⁺⁺ Channels: Inhibition by theKappa Opioid Receptor Agonist
Yuichiro Kojima, Yasuhiro Tsunoda and Chung Owyang

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 403-409;
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Impaired Contractile Response to Beta Adrenoceptor Stimulation in Diabetic Rat Hearts: Alterations in BetaAdrenoceptors-G Protein-Adenylate Cyclase System and Phospholamban Phosphorylation
Satoshi Gando, Yuichi Hattori, Yasuhiro Akaishi, Jun Nishihira and Morio Kanno

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 475-484;

BEHAVIORAL PHARMACOLOGY

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Effects of Kappa Opioids on Cocaine Self-Administration by Rhesus Monkeys
S. Stevens Negus, Nancy K. Mello, Philip S. Portoghese and Chai-En Lin

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 44-55;
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Ultrasonic Vocalizations In Rat Pups: Modulation at the γ-Aminobutyric Acid_A Receptor Complex and the Neurosteroid Recognition Site ^,
Jeffrey A. Vivian, Helena M. T. Barros, Andre Manitiu and Klaus A. Miczek

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 318-325;
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Ventilation in Morphine-Maintained Rhesus Monkeys. I: Effects of Naltrexone and Abstinence-Associated Withdrawal ^,
Carol A. Paronis and James H. Woods

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 348-354;
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Ventilation in Morphine-Maintained Rhesus Monkeys. II: Tolerance to the Antinociceptive But Not the Ventilatory Effects of Morphine ^,
Carol A. Paronis and James H. Woods

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 355-362;
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CCD-3693: An Orally Bioavailable Analog of the Endogenous Neuroactive Steroid, Pregnanolone, Demonstrates Potent Sedative Hypnotic Actions in the Rat
Dale M. Edgar, Wesley F. Seidel, Kelvin W. Gee, Nancy C. Lan, George Field, Haiji Xia, Jon E. Hawkinson, Scott Wieland, Richard B. Carter and Paul L. Wood

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 420-429;

CARDIOVASCULAR PHARMACOLOGY

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The Cardiac Effects of Pimobendan (But Not Amrinone) Are Preserved at Rest and During Exercise in Conscious Dogs with Pacing-Induced Heart Failure
Nobuyuki Ohte, Che-Ping Cheng, Makoto Suzuki and William C. Little

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 23-31;
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Electrophysiological Characterization of the Prokinetic Agents Cisapride and Mosapride in Vivo and in Vitro: Implications for Proarrhythmic Potential?
Leif Carlsson, Gregory J Amos, Birgit Andersson, Lissen Drews, Göran Duker and Gunilla Wadstedt

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 220-227;
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Structure-Activity Relationships of Spontaneous Nitric Oxide Releasers, FK409 and its Derivatives
Shinichi Fukuyama, Yoshimi Hirasawa, Yasuko Kato, Mie Nishio, Mitsuko Ohno, Shigetaka Nishino, Kazuhiro Maeda, Masayuki Kato and Yasuhiro Kita

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 236-242;
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Extracellular Mg⁺⁺ Manipulation Prevents the Proarrhythmic Activity of Cromakalim in Ischemic/Reperfused Diabetic Hearts
Arpad Tosaki and Dipak K. Das

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 309-317;
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Carvedilol Retards Sudden Loss of Contraction during Early Regional Myocardial Ischemia in Feline Hearts
Harald Brunv and and Ketil Grong

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 363-368;
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Basic Fibroblast Growth Factor in a Porcine Model of Chronic Myocardial Ischemia: A Comparison of Angiographic, Echocardiographic and Coronary Flow Parameters
John J. Lopez, Elazer R. Edelman, Alon Stamler, Mark G. Hibberd, Pottumarthi Prasad, Ronald P. Caputo, Joseph P. Carrozza, Pamela S. Douglas, Frank W. Sellke and Michael Simons

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 385-390;

CELLULAR AND MOLECULAR PHARMACOLOGY

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Action of Methylmercury on GABA_A Receptor-Mediated Inhibitory Synaptic Transmission Is Primarily Responsible for Its Early Stimulatory Effects on Hippocampal CA1 Excitatory Synaptic Transmission
Yukun Yuan and William D. Atchison

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 64-73;
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Waglerin-1 Modulates γ-Aminobutyric Acid Activated Current of Murine Hypothalamic Neurons
Jiang-Hong Ye and Joseph J. McArdle

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 74-80;
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Evaluation of the Antimyotonic Activity of Mexiletine and Some New Analogs on Sodium Currents of Single Muscle Fibers and on the Abnormal Excitability of the Myotonic ADR Mouse
Annamaria De Luca, Sabata Pierno, Fedele Natuzzi, Carlo Franchini, Andrea Duranti, Giovanni Lentini, Vincenzo Tortorella, Harald Jockusch and Diana Conte Camerino

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 93-100;
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Full Reversal of Pb⁺⁺ Block of L-Type Ca⁺⁺ Channels Requires Treatment with Heavy Metal Antidotes
Juan Bernal, Jung-Ha Lee, Leanne L. Cribbs and Edward Perez-Reyes

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 172-180;
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Pharmacological Profile of YM087, A Novel Potent Nonpeptide Vasopressin V_1A and V₂ Receptor Antagonist,in Vitro and in Vivo
Atsuo Tahara, Yuichi Tomura, Koh-Ichi Wada, Toshiyuki Kusayama, Junko Tsukada, Masahiro Takanashi, Takeyuki Yatsu, Wataru Uchida and Akihiro Tanaka

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 301-308;
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[¹²⁵I]IPH, an Epibatidine Analog, Binds with High Affinity to Neuronal Nicotinic Cholinergic Receptors
Martha I. Dávila-García, John L. Musachio, David C. Perry, Yingxian Xiao, Andrew Horti, Edythe D. London, Robert F. Dannals and Kenneth J. Kellar

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 445-451;

CHEMOTHERAPY/GENE THERAPY

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Heme Polymerase Activity and the Stage Specificity of Antimalarial Action of Chloroquine
Augustine U. Orjih

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 108-112;

DRUG METABOLISM AND DISPOSITION

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Carrier-Mediated Hepatic Uptake of Quinolone Antibiotics in the Rat
Hiroyuki Sasabe, Tetsuya Terasaki, Akira Tsuji and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 162-171;
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Role of CYP3A4 in Human Hepatic Diltiazem N-Demethylation: Inhibition of CYP3A4 Activity by Oxidized Diltiazem Metabolites
Dylan Sutton, Alison M. Butler, Louise Nadin and Michael Murray

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 294-300;
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Effect of Albumin on the Estimation, In Vitro, of Phenytoin V_max and K _m Values: Implications for Clinical Correlation
Linda K. Ludden, Thomas M. Ludden, Jerry M. Collins, Helen S. Pentikis and John M. Strong

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 391-396;

GASTROINTESTINAL PHARMACOLOGY

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Opposing Effects of Vasoactive Intestinal Polypeptide on Gastric Motor Function in the Dorsal Vagal Complex and the Nucleus Raphe Obscurus of the Rat
Zbigniew K. Krowicki, Nicole A. Nathan and Pamela J. Hornby

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 14-22;
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l-Arginine Deficiency Causes Suppression of Nonadrenergic Noncholinergic Nerve-Mediated Smooth Muscle Relaxation: Role of l-Citrulline Recycling
Sushanta Chakder and Satish Rattan

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 378-384;
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Contractile Action of Ethanol in Guinea Pig Gastric Smooth Muscle: Inhibition by Tyrosine Kinase Inhibitors and Comparison with the Contractile Action of Epidermal Growth Factor-Urogastrone
Xi-Long Zheng, Shalini Mokashi and Morley D. Hollenberg

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 485-495;

IMMUNOPHARMACOLOGY

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Ethodin: Pharmacological Evidence of the Interaction between Smooth Muscle and Mast Cells in the Myometrium
María Isolde Rudolph, Maria de los Angeles García, Marcia Sepulveda, Enrique Brandan, Karin Reinicke, Sandra Nicovani and Leonor Villan

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 256-261;
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MK-801 Limits Neurovascular Dysfunction during Experimental Allergic Encephalomyelitis
Christopher Bolton and Carolyn Paul

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 397-402;
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The Natural Product Hymenialdisine Inhibits Interleukin-8 Production in U937 Cells by Inhibition of Nuclear Factor-κB
John J. Breton and Marie C. Chabot-Fletcher

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 459-466;
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Differential Regulation of Human Antigen-Specific Th1 and Th2 Lymphocyte Responses by Isozyme Selective Cyclic Nucleotide Phosphodiesterase Inhibitors
David M. Essayan, Anne Kagey-Sobotka, Lawrence M. Lichtenstein and Shau-Ku Huang

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 505-512;

NEUROPHARMACOLOGY

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The Kappa Opioid Agonist Niravoline Decreases Brain Edema in the Mouse Middle Cerebral Artery Occlusion Model of Stroke
Claude Guéniau and Claude Oberlander

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 1-6;
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Effect of Smoking History on [³H]Nicotine Binding in Human Postmortem Brain
Charles R. Breese, Michael J. Marks, Judy Logel, Cathy E. Adams, Bernadette Sullivan, Allan C. Collins and Sherry Leonard

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 7-13;
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Pharmacological Comparison of Transient and Persistent [³H]Dopamine Release from Mouse Striatal Synaptosomes and Response to Chronic l-Nicotine Treatment
Sharon R. Grady, Elizabeth U. Grun, Michael J. Marks and Allan C. Collins

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 32-43;
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In Vitro and In Vivo Characterization of the Dopamine D₄ Receptor, Serotonin 5-HT_2AReceptor and Alpha-1 Adrenoceptor Antagonist (R)-(+)-2-Amino-4-(4-Fluorophenyl)- 5-[1-[4-(4-Fluorophenyl)-4-Oxobutyl]Pyrrolidin-3-yl]Thiazole (NRA0045)
Shigeru Okuyama, Shigeyuki Chaki, Ryoko Yoshikawa, Yoshiko Suzuki, Shin-Ichi Ogawa, Yasuko Imagawa, Naoya Kawashima, Yoko Ikeda, Toshihito Kumagai, Atsuro Nakazato, Masashi Nagamine and Kazuyuki Tomisawa

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 56-63;
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Transport of Clonidine Across Cultured Brain Microvessel Endothelial Cells
Jörg Huwyler, Gert Fricker, Michael Török, Markus Schneider and Jürgen Drewe

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 81-85;
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S 15535, A Novel Benzodioxopiperazine Ligand of Serotonin (5-HT)_1A Receptors: I. Interaction with Cloned Human (h)5-HT_1A, Dopamine hD₂/hD₃ and hα_2A-Adrenergic Receptors in Relation to Modulation of Cortical Monoamine Release and Activity in Models of Potential Antidepressant Activity
Mark J. Millan, Adrian Newman-Tancredi, Jean-Michel Rivet, Mauricette Brocco, Pierre Lacroix, Valérie Audinot, Laetitia Cistarelli and Alain Gobert

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 132-147;
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S 15535, A Novel Benzodioxopiperazine Ligand of Serotonin (5-HT)_1A Receptors: II. Modulation of Hippocampal Serotonin Release in Relation to Potential Anxiolytic Properties
Mark J. Millan, Stephan Hjorth, Rosario Samanin, Rudy Schreiber, Robert Jaffard, Brigitte De Ladonchamps, Sylvie Veiga, Bertrand Goument, Jean-Louis Peglion, Michael Spedding and Mauricette Brocco

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 148-161;
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[³⁵S]Guanosine-5′-O-(3-thio)triphosphate Binding as a Measure of Efficacy at Human Recombinant Dopamine D_4.4Receptors: Actions of Antiparkinsonian and Antipsychotic Agents
A. Newman-Tancredi, V. Audinot, C. Chaput and L.Verrièle and M. J. Millan

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 181-191;
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The Potassium Channel Blockers 4-Aminopyridine and Tetraethylammonium Increase the Spontaneous Basal Release of [³H]5-Hydroxytryptamine in Rat Hippocampal Slices
Lee E. Schechter

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 262-270;
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Antagonism of N-Methyl-d-Aspartate Receptors by ς Site Ligands: Potency, Subtype-Selectivity and Mechanisms of Inhibition
E. R. Whittemore, V. I. Ilyin and R. M. Woodward

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 326-338;
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Pharmacology of Lobeline, A Nicotinic Receptor Ligand
M. I. Damaj, G. S. Patrick, K. R. Creasy and B. R. Martin

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 410-419;
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N-(3-Iodoprop-2E-enyl)-2β-carbomethoxy-3β-(3′,4′-dichlorophenyl)nortropane (β-CDIT), a Tropane Derivative: Pharmacological Characterization as a Specific Ligand for the Dopamine Transporter in the Rodent Brain
Lucette Garreau, Patrick Emond, Catherine Belzung, Denis Guilloteau, Yves Frangin, Jean-Claude Besnard and Sylvie Chalon

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 467-474;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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Analysis of Eicosanoid Mediation of the Renal Functional Effects of Hyperchloremia ^,
Bardia Askari, Caroline P. Bell-Quilley, David Fulton, John Quilley and John C. McGiff

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 101-107;
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Signal Transduction Mechanism(s) Involved in Prostacyclin Production Elicited by Acetylcholine in Coronary Endothelial Cells of Rabbit Heart
H. Kan, Y. Ruan and K. U. Malik

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 113-122;
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Variabilin: A Dual Inhibitor of Human Secretory and Cytosolic Phospholipase A₂ With Anti-inflammatory Activity
V. Escrig, A. Ubeda, M. L. Ferrandiz, J. Darias, J. M. Sanchez, M. J. Alcaraz and M. Paya

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 123-131;
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The Biodisposition and Metabolism of Anandamide in Mice
Karen A. Willoughby, Sandra F. Moore, Billy R. Martin and Earl F. Ellis

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 243-247;
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Potencies of Leflunomide and HR325 as Inhibitors of Prostaglandin Endoperoxide H Synthase-1 and -2: Comparison with Nonsteroidal Anti-Inflammatory Drugs
Adam P. Curnock, Peter A. Robson, Christopher M. Yea, David Moss, Suresh Gadher, T. Andrew Thomson, Robert Westwood, Erik Ruuth and Richard A. Williamson

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 339-347;
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Induction of Prostaglandin Endoperoxide Synthase-2 by Serine-Threonine Phosphatase Inhibition
Keyvan Mahboubi, Wilson Young and Nicholas R. Ferreri

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 452-458;
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Involvement of Phospholipase C-γ2 in Activation of Mitogen-Activated Protein Kinase and Phospholipase A₂ by Zooxanthellatoxin-A in Rabbit Platelets
Mun-Chual Rho, Norimichi Nakahata, Hideshi Nakamura, Akio Murai and Yasushi Ohizumi

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 496-504;

PULMONARY PHARMACOLOGY

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Selective O-Desulfation Produces Nonanticoagulant Heparin that Retains Pharmacological Activity in the Lung ^,
Allison Fryer, Yuh-Chin Huang, Gopna Rao, David Jacoby, Edward Mancilla, Richard Whorton, Claude A. Piantadosi, Thomas Kennedy and John Hoidal

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 208-219;

RENAL PHARMACOLOGY

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p-Glycoprotein-Mediated Transport of a Fluorescent Rapamycin Derivative in Renal Proximal Tubule
David S. Miller, Gert Fricker and Juergen Drewe

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 440-444;

TOXICOLOGY

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DMPS-Arsenic Challenge Test. I: Increased Urinary Excretion of Monomethylarsonic Acid in Humans Given Dimercaptopropane Sulfonate
H. Vasken Aposhian, Alex Arroyo, Mariano E. Cebrian, Luz María Del Razo, Katherine M. Hurlbut, Richard C. Dart, Diego Gonzalez-Ramirez, Helmut Kreppel, Hernan Speisky, Allan Smith, Maria E. Gonsebatt, Patricia Ostrosky-Wegman and Mary M. Aposhian

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 192-200;
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Protection from Gentamicin Ototoxicity by Iron Chelators in Guinea Pig In Vivo ^,
Ben-Bo Song, David J. Anderson and Jochen Schacht

Journal of Pharmacology and Experimental Therapeutics July 1997, 282 (1) 369-377;

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Table of Contents

ANALGESIA AND DRUGS OF ABUSE

AUTONOMIC PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR PHARMACOLOGY

CELLULAR AND MOLECULAR PHARMACOLOGY

CHEMOTHERAPY/GENE THERAPY

DRUG METABOLISM AND DISPOSITION

GASTROINTESTINAL PHARMACOLOGY

IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

PULMONARY PHARMACOLOGY

RENAL PHARMACOLOGY

TOXICOLOGY

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