Interaction of a Thrombin Inhibitor and a Platelet GP IIb/IIIa Antagonist In Vivo: Evidence That Thrombin Mediates Platelet Aggregation and Subsequent Thromboxane A2 Formation During Coronary Thrombolysis

Domenico Pratico; Natalie P. Murphy; Desmond J. Fitzgerald

Article Information

vol. 281 no. 3 1178-1185

PubMed

9190851

Published By

American Society for Pharmacology and Experimental Therapeutics

Print ISSN

0022-3565

Online ISSN

1521-0103

History

Received October 9, 1996
Accepted February 24, 1997
Published online June 1, 1997.

The American Society for Pharmacology and Experimental Therapeutics

Author Information

Domenico Pratico2,
Natalie P. Murphy and
Desmond J. Fitzgerald

Centre for Cardiovascular Science, Dept. of Clinical Pharmacology, Royal College of Surgeons in Ireland, St. Stephens Green, Dublin, Ireland

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Interaction of a Thrombin Inhibitor and a Platelet GP IIb/IIIa Antagonist In Vivo: Evidence That Thrombin Mediates Platelet Aggregation and Subsequent Thromboxane A₂ Formation During Coronary Thrombolysis

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Interaction of a Thrombin Inhibitor and a Platelet GP IIb/IIIa Antagonist In Vivo: Evidence That Thrombin Mediates Platelet Aggregation and Subsequent Thromboxane A₂ Formation During Coronary Thrombolysis

Interaction of a Thrombin Inhibitor and a Platelet GP IIb/IIIa Antagonist In Vivo: Evidence That Thrombin Mediates Platelet Aggregation and Subsequent Thromboxane A₂ Formation During Coronary Thrombolysis

Interaction of a Thrombin Inhibitor and a Platelet GP IIb/IIIa Antagonist In Vivo: Evidence That Thrombin Mediates Platelet Aggregation and Subsequent Thromboxane A₂ Formation During Coronary Thrombolysis