Journal of Pharmacology and Experimental Therapeutics: 281 (3)

June 01, 1997; Volume 281,Issue 3

ANALGESIA AND DRUGS OF ABUSE

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Analgesia by Dihydrocodeine Is Not Due to Formation of Dihydromorphine: Evidence from Nociceptive Activity in Rat Thalamus
Ilmar Jurna, Wolfgang Kömen, Joseph Baldauf and Wolfgang Fleischer

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1164-1170;
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Spinal Infusion of N-methyl-d-aspartate Antagonist MK801 Induces Hypersensitivity to the Spinal Alpha-2 Agonist ST91 in the Rat
Stuart A. Dunbar and Tony L. Yaksh

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1219-1225;
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Differential Effects of Naltrindole on Morphine-Induced Tolerance and Physical Dependence in Rats
Matthew J. Hepburn, Patrick J. Little, Jeanine Gingras and Cynthia M. Kuhn

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1350-1356;
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Effects of Intrathecal or Intracerebroventricular Administration of Nonsteroidal Anti-inflammatory Drugs on a C-Fiber Reflex in Rats
Diego Bustamante, Carlos Paeile, Jean-Claude Willer and Daniel Le Bars

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1381-1391;
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Changes in the Association of G Protein Subunits with the Cloned Mouse Delta Opioid Receptor on Agonist Stimulation
Susan F. Law and Terry Reisine

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1476-1486;

AUTONOMIC PHARMACOLOGY

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Characterization of Alpha-2D Adrenergic Receptor Subtypes in Bovine Ocular Tissue Homogenates
David B. Bylund, Laurie J. Iversen, William J. Matulka and David M. Chacko

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1171-1177;
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Pharmacological Characterization of the UroselectiveAlpha-1 Antagonist Rec 15/2739 (SB 216469): Role of theAlpha-1L Adrenoceptor in Tissue Selectivity, Part I
A. Leonardi, J. P. Hieble, L. Guarneri, D. P. Naselsky, E. Poggesi, G. Sironi, A. C. Sulpizio and R. Testa

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1272-1283;
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Pharmacological Characterization of the UroselectiveAlpha-1 Antagonist Rec 15/2739 (SB 216469): Role of theAlpha-1L Adrenoceptor in Tissue Selectivity, Part II
R. Testa, L. Guarneri, P. Angelico, E. Poggesi, C. Taddei, G. Sironi, D. Colombo, A. C. Sulpizio, D. P. Naselsky, J. P. Hieble and A. Leonardi

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1284-1293;

BEHAVIORAL PHARMACOLOGY

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Differential Reinforcement of Low Rate Performance, Pharmacokinetics and Pharmacokinetic-Pharmacodynamic Modeling: Independent Interaction of Alprazolam and Caffeine
Chyan E. Lau, Yunxia Wang and John L. Falk

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1013-1029;
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Human Pharmacology of the Opioid Neuropeptide Dynorphin A(1–13)
Mark K. Greenwald, Maxine L. Stitzer and Kathleen A. Haberny

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1154-1163;
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CP-96,345, which Inhibits [³H] Substance P Binding, Selectively Inhibits the Behavioral Response to Intrathecally Administered N-Methyl-d-Aspartate, but not Substance P, in the Mouse
Rubén A. Velázquez, Kelley F. Kitto and Alice A. Larson

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1231-1237;
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Pharmacodynamics of Acute Tolerance to Multiple Nicotinic Effects in Humans
Karin Fattinger, Davide Verotta and Neal L. Benowitz

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1238-1246;
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Alprazolam in Young and Elderly Men: Sensitivity and Tolerance to Psychomotor, Sedative and Memory Effects
Richard J. Bertz, Patricia D. Kroboth, Frank J. Kroboth, Ian J. Reynolds, Firoozeh Salek, C. Eugene Wright and Randall B. Smith

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1317-1329;
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Enhancement of Amphetamine- and Cocaine-Induced Locomotor Activity after Chronic Ethanol Administration
S. J. Manley and H. J. Little

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1330-1339;
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Effects of Drugs on Response Duration Differentiation. V: Differential Effects under Temporal Response Differentiation Schedules
G. Y. H. Mcclure, G. R. Wenger and D. E. Mcmillan

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1357-1367;
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Effects of Drugs on Response Duration Differentiation. VI: Differential Effects under Differential Reinforcement of Low Rates of Responding Schedules
G. Y. H. Mcclure and D. E. Mcmillan

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1368-1380;
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Glucocorticoids and Behavioral Effects of Psychostimulants. I: Locomotor Response to Cocaine Depends on Basal Levels of Glucocorticoids
Michela Marinelli, Françoise Rougé-Pont, Véronique Deroche, Michel Barrot, Cécile De Jésus-Oliveira, Michel Le Moal and Pier Vincenzo Piazza

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1392-1400;
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Glucocorticoids and Behavioral Effects of Psychostimulants. II: Cocaine Intravenous Self-administration and Reinstatement Depend on Glucocorticoid Levels
Véronique Deroche, Michela Marinelli, Michel Le Moal and Pier Vincenzo Piazza

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1401-1407;
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Selective Serotonin Reuptake Inhibitors Dissociate Fenfluramine’s Anorectic and Neurotoxic Effects: Importance of Dose, Species and Drug
Una D. Mccann, Jie Yuan, George Hatzidimitriou and George A. Ricaurte

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1487-1498;

CARDIOVASCULAR PHARMACOLOGY

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Cannabinoid-Induced Hypotension and Bradycardia in Rats Is Mediated by CB₁-Like Cannabinoid Receptors
Kristy D. Lake, David R. Compton, Karoly Varga, Billy R. Martin and George Kunos

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1030-1037;
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Nonpeptide Angiotensin II Antagonist Losartan Inhibits Thromboxane A₂-Induced Contractions in Canine Coronary Arteries
Ping Li, Carlos M. Ferrario and K. Bridget Brosnihan

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1065-1070;
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Acute Effects of Nitric Oxide and Cyclic GMP on Human Myocardial Contractility
Markus Flesch, Heiko Kilter, Bodo Cremers, Olaf Lenz, Michael Südkamp, Ferdinand Kuhn-Regnier and Michael Böhm

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1340-1349;
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Effects of Preconditioning with Ebselen on Glutathione Metabolism and Stress Protein Expression
Shiro Hoshida, Kazuhiro Aoki, Masashi Nishida, Nobushige Yamashita, Junsuke Igarashi, Masatsugu Hori, Tsunehiko Kuzuya and Michihiko Tada

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1471-1475;
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Investigation of Aortic CYP3A Bioactivation of Nitroglycerin In Vivo
Rae Yuan, Masahiro Sumi and Leslie Z. Benet

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1499-1505;

CELLULAR AND MOLECULAR PHARMACOLOGY

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Beta Adrenergic Receptor Stimulated Prostacyclin Synthesis in Rabbit Coronary Endothelial Cells Is Mediated by Selective Activation of Phospholipase D: Inhibition by Adenosine 3′5′-Cyclic Monophosphate
Ying Ruan, Hong Kan and Kafait U. Malik

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1038-1046;
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Possible Mechanism of Palytoxin-Induced Ca⁺⁺Mobilization in Porcine Coronary Artery
Kazuo Ishii, Kaoru M. Ito, Daisuke Uemura and Katsuaki Ito

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1077-1084;
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Inhibition of 5-Hydroxytryptamine Type 2A Receptor-Induced Currents by n-Alcohols and Anesthetics
Kouichiro Minami, Makiko Minami and R. Adron Harris

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1136-1143;
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Pharmacological Control of the Mevalonate Pathway: Effect on Arterial Smooth Muscle Cell Proliferation
Marco Raiteri, Lorenzo Arnaboldi, Paul Mcgeady, Michael H. Gelb, Daniela Verri, Carlo Tagliabue, Pierangelo Quarato, Patrizia Ferraboschi, Enzo Santaniello, Rodolfo Paoletti, Remo Fumagalli and Alberto Corsini

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1144-1153;
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Characterization of Nifedipine Block of the Human Heart Delayed Rectifier, hKv1.5
Xue Zhang, James W. Anderson and David Fedida

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1247-1256;
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Regulation of [Ca⁺⁺]_i in Human Neuroblastoma (SH-SY5Y) Cells Expressing Recombinant Rat Angiotensin_1A Receptors by Angiotensin II and Carbachol
R. L. McDonald, D. J. Roberts, A. C. V. Palmer, S. G. Ball, P. F. T. Vaughan and C. Peers

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1257-1263;
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Nonpeptide Tachykinin Receptor Antagonists: I. Pharmacological and Pharmacokinetic Characterization of SB 223412, a Novel, Potent and Selective Neurokinin-3 Receptor Antagonist
Henry M. Sarau, Don E. Griswold, William Potts, James J. Foley, Dulcie B. Schmidt, Edward F. Webb, Lenox D. Martin, Mary E. Brawner, Nabil A. Elshourbagy, Andrew D. Medhurst, Giuseppe A. M. Giardina and Douglas W. P. Hay

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1303-1311;
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Inhibition of Growth Factor-Mediated Tyrosine Phosphorylation in Vascular Smooth Muscle by PD 089828, a New Synthetic Protein Tyrosine Kinase Inhibitor
Tawny K. Dahring, Gina H. Lu, James M. Hamby, Brian L. Batley, Alan J. Kraker and Robert L. Panek

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1446-1456;
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Involvement of Nitric Oxide in Nicotinic Receptor-Mediated Myopathy
Manar D. El-Dada and Maryka Quik

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1463-1470;

CHEMOTHERAPY/GENE THERAPY

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The Treatment of Animal Models of Malaria with Iron Chelators by Use of a Novel Polymeric Device for Slow Drug Release
Jacob Golenser, Abraham Domb, Doron Teomim, Appolinaire Tsafack, Orna Nisim, Prem Ponka, Wijnand Eling and Z. Ioav Cabantchik

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1127-1135;
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Multidrug Resistance-Reversing Agents Increase Vinblastine Distribution in Normal Tissues Expressing the P-Glycoprotein but Do Not Enhance Drug Penetration in Brain and Testis
Margarita Arboix, Odalys Gonzalez Paz, Tina Colombo and Maurizio D’Incalci

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1226-1230;

DRUG METABOLISM AND DISPOSITION

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Pharmacokinetics and Pharmacodynamics of the Enantiomers of Gallopamil
A. S. Gross, G. Mikus, D. Ratge, H. Wisser and M. Eichelbaum

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1102-1112;
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Reappraisal of Human CYP Isoforms Involved in ImipramineN-Demethylation and 2-Hydroxylation: A Study Using Microsomes Obtained from Putative Extensive and Poor Metabolizers ofS-Mephenytoin and Eleven Recombinant Human CYPs
Eriko Koyama, Kan Chiba, Masanao Tani and Takashi Ishizaki

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1199-1210;

ENDOCRINE PHARMACOLOGY

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In Vivo Characterization of Sustained-Release Formulations of Human Growth Hormone
Hye Jung Lee, Gary Riley, Olufumni Johnson, Jeffrey L. Cleland, Norman Kim, Margarita Charnis, Leonie Bailey, Eileen Duenas, Azin Shahzamani, Melinda Marian, Andrew J. S. Jones and Scott D. Putney

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1431-1439;

GASTROINTESTINAL PHARMACOLOGY

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Platelet-Activating Factor Contributes to Immune Cell and Oxidant-Mediated Intestinal Secretion ^,
Thomas A. Hinterleitner, John D. Valentich, Jih-Ho Cha, Peter Will, Ann Welton and Don W. Powell

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1264-1271;
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Neurokinin A-Induced Vasoconstriction and Muscular Contraction in the Rat Isolated Stomach: Mediation by Distinct and Unusual Neurokinin₂ Receptors
Irmgard Th. Lippe, Christof H. Wachter and Peter Holzer

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1294-1302;
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Effect of Cisapride and Renzapride on Gastrointestinal Motility and Plasma Motilin Concentration in Dogs
C. W. Song, K. Y. Lee, C. D. Kim, T-M. Chang and W. Y. Chey

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1312-1316;
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Characterization of Stably Transfected Kidney Epithelial Cell Line Expressing Rat H⁺/Peptide Cotransporter PEPT1: Localization of PEPT1 and Transport of β-Lactam Antibiotics
Tomohiro Terada, Hideyuki Saito, Mayumi Mukai and Ken-Ichi Inui

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1415-1421;

NEUROPHARMACOLOGY

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Partial Agonism by 3α,21-Dihydroxy-5β-pregnan-20-one at the γ-Aminobutyric Acid_A Receptor Neurosteroid Site
Bao G. Xue, Edward R. Whittemore, Chong H. Park, Richard M. Woodward, Nancy C. Lan and Kelvin W. Gee

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1095-1101;
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Differential Muscarinic Receptor Binding of Acetylcholinesterase Inhibitors in Rat Brain, Human Brain and Chinese Hamster Ovary Cells Expressing Human Receptors
Ingeborg van den Beukel, Fred A. Dijcks, Patrick Vanderheyden, Georges Vauquelin and Marga Oortgiesen

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1113-1119;
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Anticonvulsant Action of 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline in Immature Rats: Comparison with the Effects on Motor Performance
P. Mares, A. Mikulecká and M. Pometlová

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1120-1126;
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The Stereo-Isomers of the Anticonvulsant ARL 12495AA Limit Sustained Repetitive Firing and Modify Action Potential Properties of Rat Hippocampal Neurons in Vitro
S. K. Norris and A. E. King

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1191-1198;
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The Passage of Azidodeoxythymidine into and within the Central Nervous System: Does It Follow the Parent Compound, Thymidine?
Sarah A. Thomas and Malcolm B. Segal

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1211-1218;
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Functional Activation of Cerebral Blood Flow Abolished by Scopolamine Is Reversed by Cognitive Enhancers Associated with Cholinesterase Inhibition: A Positron Emission Tomography Study in Unanesthetized Monkeys
Hideo Tsukada, Takeharu Kakiuchi, Ichiro Ando and Yasuomi Ouchi

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1408-1414;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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Bioavailability, Antinociceptive and Antiinflammatory Properties of BP 2-94, a Histamine H₃ Receptor Agonist Prodrug
A. Rouleau, M. Garbarg, X. Ligneau, C. Mantion, P. Lavie, C. Advenier, J.-M. Lecomte, M. Krause, H. Stark, W. Schunack and J.-C. Schwartz

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1085-1094;
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Interaction of a Thrombin Inhibitor and a Platelet GP IIb/IIIa Antagonist In Vivo: Evidence That Thrombin Mediates Platelet Aggregation and Subsequent Thromboxane A₂ Formation During Coronary Thrombolysis
Domenico Pratico, Natalie P. Murphy and Desmond J. Fitzgerald

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1178-1185;

PULMONARY PHARMACOLOGY

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Differences in Platelet-Activating Factor Receptor Mediated Ca⁺⁺ Response Between Hamster and Guinea Pig Alveolar Macrophages
Jin Chen and Shri N. Giri

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1047-1058;
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Stimulation of Airway Mucociliary Transport and Epithelial Ciliary Motility by the Triazolopyridazin Derivative TAK-225
J. Tamaoki, A. Chiyotani, H. Takemura, K. Konno, T. Matsumoto and Y. Ashida

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1186-1190;
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Immunochemical Assay for Recognition of 2-S-Glutathionyl Acetate, a Glutathione Conjugate Derived from 1,1-Dichloroethylene-Epoxide
Poh-Gek Forkert, Kathy S. Collins, Taylor F. Dowsley and Gregory M. Ross

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1422-1430;

RENAL PHARMACOLOGY

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α-Ketoglutarate Transport in Rat Renal Brush-Border and Basolateral Membrane Vesicles
Richard M. Edwards, Elwood Stack and Walter Trizna

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1059-1064;
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Excretion and Metabolism of Propionyl- l -carnitine in the Isolated Perfused Rat Kidney
Allan M. Evans, Angelo Mancinelli and Antonio Longo

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1071-1076;
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Phosphate Excretion and Phosphate Transporter Messenger RNA in Uremic Rats Treated with Phosphonoformic Acid
David P. Brooks, Shujath M. Ali, Lisa C. Contino, Elwood Stack, Todd A. Fredrickson, John Feild and Richard M. Edwards

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1440-1445;
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Effects of Rebamipide in a Model of Experimental Diabetes and on the Synthesis of Transforming Growth Factor-β and Fibronectin, and Lipid Peroxidation Induced by High Glucose in Cultured Mesangial Cells
Hunjoo Ha, Sang H. Lee and K. Hwan Kim

Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1457-1462;

Erratum

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Correction for vol. 277, p. 423
Journal of Pharmacology and Experimental Therapeutics June 1997, 281 (3) 1506;

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Table of Contents

ANALGESIA AND DRUGS OF ABUSE

AUTONOMIC PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR PHARMACOLOGY

CELLULAR AND MOLECULAR PHARMACOLOGY

CHEMOTHERAPY/GENE THERAPY

DRUG METABOLISM AND DISPOSITION

ENDOCRINE PHARMACOLOGY

GASTROINTESTINAL PHARMACOLOGY

NEUROPHARMACOLOGY

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

PULMONARY PHARMACOLOGY

RENAL PHARMACOLOGY

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