Studies on the Metabolic Activation of Disulfiram in Rat. Evidence for Electrophilic S-Oxygenated Metabolites as Inhibitors of Aldehyde Dehydrogenase and Precursors of UrinaryN-Acetylcysteine Conjugates

Pei Hu; Lixia Jin; Thomas A. Baillie

Article Information

vol. 281 no. 2 611-617

PubMed

9152363

Published By

American Society for Pharmacology and Experimental Therapeutics

Print ISSN

0022-3565

Online ISSN

1521-0103

History

Received July 24, 1996
Accepted December 16, 1996
Published online May 1, 1997.

The American Society for Pharmacology and Experimental Therapeutics

Author Information

Pei Hu2,
Lixia Jin3 and
Thomas A. Baillie3

Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington

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