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OtherDRUG METABOLISM AND DISPOSITION

Inhibition of Cytochrome P450 2D6 Metabolism of Hydrocodone to Hydromorphone Does Not Importantly Affect Abuse Liability

Howard L. Kaplan, Usoa E. Busto, Godofredo J. Baylon, Siu W. Cheung, S. Victoria Otton, Gail Somer and Edward M. Sellers
Journal of Pharmacology and Experimental Therapeutics April 1997, 281 (1) 103-108;
Howard L. Kaplan
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Usoa E. Busto
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Godofredo J. Baylon
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Siu W. Cheung
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S. Victoria Otton
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Gail Somer
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Edward M. Sellers
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Article Information

vol. 281 no. 1 103-108
PubMed 
9103485

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 29, 1996
  • Accepted November 5, 1996
  • Published online April 1, 1997.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Howard L. Kaplan1,2,
  2. Usoa E. Busto1,2,4,
  3. Godofredo J. Baylon1,2,
  4. Siu W. Cheung1,
  5. S. Victoria Otton1,
  6. Gail Somer1,2 and
  7. Edward M. Sellers1,2,3
  1. 1Biobehavioural Research Department, Addiction Research Foundation (H.L.K., U.E.B., G.J.B., S.W.C., S.V.O., G.S., E.M.S.); 2Psychopharmacology and Dependence Research Unit, Women’s College Hospital (H.L.K., U.E.B., G.J.B., G.S., E.M.S.); Departments of 3Pharmacology, Medicine and Psychiatry, Faculty of Medicine, University of Toronto (E.M.S.); and 4Faculty of Pharmacy, University of Toronto (U.E.B.), Toronto, Ontario, Canada
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    1 Apr 1997
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    OtherDRUG METABOLISM AND DISPOSITION

    Inhibition of Cytochrome P450 2D6 Metabolism of Hydrocodone to Hydromorphone Does Not Importantly Affect Abuse Liability

    Howard L. Kaplan, Usoa E. Busto, Godofredo J. Baylon, Siu W. Cheung, S. Victoria Otton, Gail Somer and Edward M. Sellers
    Journal of Pharmacology and Experimental Therapeutics April 1, 1997, 281 (1) 103-108;

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    OtherDRUG METABOLISM AND DISPOSITION

    Inhibition of Cytochrome P450 2D6 Metabolism of Hydrocodone to Hydromorphone Does Not Importantly Affect Abuse Liability

    Howard L. Kaplan, Usoa E. Busto, Godofredo J. Baylon, Siu W. Cheung, S. Victoria Otton, Gail Somer and Edward M. Sellers
    Journal of Pharmacology and Experimental Therapeutics April 1, 1997, 281 (1) 103-108;
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