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Characterization of the Anticonvulsant Properties of Ganaxolone (CCD 1042; 3α-Hydroxy-3β-methyl-5α-pregnan-20-one), a Selective, High-Affinity, Steroid Modulator of the γ-Aminobutyric AcidA Receptor

Richard B. Carter, Paul L. Wood, Scott Wieland, Jon E. Hawkinson, Delia Belelli, Jeremy J. Lambert, H. Steve White, Harold H. Wolf, Seid Mirsadeghi, S. Hasan Tahir, Michael B. Bolger, Nancy C. Lan and Kelvin W. Gee
Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1284-1295;

Article Information

vol. 280 no. 3 1284-1295
PubMed 
9067315
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 22, 1996
  • Accepted November 14, 1996
  • Published online March 1, 1997.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Richard B. Carter1,
  2. Paul L. Wood1,
  3. Scott Wieland1,
  4. Jon E. Hawkinson1,
  5. Delia Belelli3,
  6. Jeremy J. Lambert3,
  7. H. Steve White4,
  8. Harold H. Wolf4,
  9. Seid Mirsadeghi2,
  10. S. Hasan Tahir2,
  11. Michael B. Bolger5,
  12. Nancy C. Lan2 and
  13. Kelvin W. Gee6
  1. Departments of 1Pharmacology (R.B.C., P.L.W., S.W., J.E.H.) and 2Medicinal Chemistry (S.M., S.H.T., N.C.L.), CoCensys, Inc., Irvine, California; 3Department of Pharmacology, University of Dundee, Scotland (D.B., J.J.L.); 4Anticonvulsant Screening Program, Department of Pharmacology, University of Utah, Salt Lake City, Utah (H.S.W., H.H.W.); 5School of Pharmacy, University of Southern California, Los Angeles, California (M.B.B.); and 6Department of Pharmacology, College of Medicine, University of California, Irvine, California (K.W.G.)
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    OtherBEHAVIORAL PHARMACOLOGY

    Characterization of the Anticonvulsant Properties of Ganaxolone (CCD 1042; 3α-Hydroxy-3β-methyl-5α-pregnan-20-one), a Selective, High-Affinity, Steroid Modulator of the γ-Aminobutyric AcidA Receptor

    Richard B. Carter, Paul L. Wood, Scott Wieland, Jon E. Hawkinson, Delia Belelli, Jeremy J. Lambert, H. Steve White, Harold H. Wolf, Seid Mirsadeghi, S. Hasan Tahir, Michael B. Bolger, Nancy C. Lan and Kelvin W. Gee
    Journal of Pharmacology and Experimental Therapeutics March 1, 1997, 280 (3) 1284-1295;
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