Journal of Pharmacology and Experimental Therapeutics: 280 (3)

March 01, 1997; Volume 280,Issue 3

THE 1996 ASPET OTTO KRAYER AWARD LECTURE

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Properties of Neuronal Nicotinic Acetylcholine Receptors: Pharmacological Characterization and Modulation of Synaptic Function ^,
Edson X. Albuquerque, Manickavasagom Alkondon, Edna F. R. Pereira, Newton G. Castro, Andre Schrattenholz, Catão T. F. Barbosa, Rafael Bonfante-Cabarcas, Yasco Aracava, Howard M. Eisenberg and Alfred Maelicke

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1117-1136;

ANALGESIA AND DRUGS OF ABUSE

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DynorphinA-(2–17) Restores Spinal/Supraspinal Morphine Synergy in Morphine-Tolerant Mice
Li He and N. M. Lee

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1210-1214;
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Effect of Cytochrome P450 2D1 Inhibition on Hydrocodone Metabolism and its Behavioral Consequences in Rats
D. M. Tomkins, S. V. Otton, N. Joharchi, N-Y. Li, R. F. Balster, R. F. Tyndale and E. M. Sellers

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1374-1382;
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Antisense Oligodeoxynucleotides to Opioid Mu andDelta Receptors Reduced Morphine Dependence in Mice: Role of Delta-2 Opioid Receptors
Pilar Sánchez-Blázquez, Antonio García-España and Javier Garzón

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1423-1431;

AUTONOMIC PHARMACOLOGY

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Stress Increases Plasma Enzyme Activity in Rats: Differential Effects of Adrenergic and Cholinergic Blockades
Hiroyuki Arakawa, Hiroshi Kodama, Nobuya Matsuoka and Isamu Yamaguchi

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1296-1303;

BEHAVIORAL PHARMACOLOGY

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Comparing the Subjective, Psychomotor and Physiological Effects of Intravenous Nalbuphine and Morphine in Healthy Volunteers
James P. Zacny, Kim Conley and Sandy Marks

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1159-1169;
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FK960 [N-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide Monohydrate], a Novel Potential Antidementia Drug, Improves Visual Recognition Memory in Rhesus Monkeys: Comparison with Physostigmine
Nobuya Matsuoka and Thomas G. Aigner

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1201-1209;
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Effects of γ-Aminobutyric Acid Agonists andN-Methyl-d-aspartate Antagonists on a Multiple Schedule of Ethanol and Saccharin Self-administration in Rats
Keith L. Shelton and Robert L. Balster

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1250-1260;
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Characterization of the Anticonvulsant Properties of Ganaxolone (CCD 1042; 3α-Hydroxy-3β-methyl-5α-pregnan-20-one), a Selective, High-Affinity, Steroid Modulator of the γ-Aminobutyric Acid_A Receptor
Richard B. Carter, Paul L. Wood, Scott Wieland, Jon E. Hawkinson, Delia Belelli, Jeremy J. Lambert, H. Steve White, Harold H. Wolf, Seid Mirsadeghi, S. Hasan Tahir, Michael B. Bolger, Nancy C. Lan and Kelvin W. Gee

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1284-1295;

CARDIOVASCULAR PHARMACOLOGY

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Electrophysiologic Effects of Nibentan (HE-11) on Canine Cardiac Tissue
Evgeny P. Anyukhovsky, Eugene A. Sosunov and Michael R. Rosen

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1137-1146;
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Effects of Renal Papillary-Medullary Lesion on the Antihypertensive Effect of Furosemide and Development of Salt-Sensitive Hypertension in Dahl-S Rats
Ketil Haugan, Michael Shalmi, Jørgen Søberg Petersen, Niels Marcussen, Jesper Spannow and Sten Christensen

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1415-1422;

CELLULAR AND MOLECULAR PHARMACOLOGY

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Inhibition of Cardiac Potassium Currents by the Vesnarinone Analog OPC-18790: Comparison with Quinidine and Dofetilide
Tao Yang, Dirk J. Snyders and Dan M. Roden

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1170-1175;
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Effect of Cilnidipine, a Novel Dihydropyridine Ca⁺⁺-channel antagonist, on N-type Ca⁺⁺ Channel in Rat Dorsal Root Ganglion Neurons
Shigeo Fujii, Kimiko Kameyama, Masahiro Hosono, Yutaka Hayashi and Kenji Kitamura

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1184-1191;
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Up-regulation of Platelet-activating Factor Receptors in Lung and Alveolar Macrophages in the Bleomycin-Hamster Model of Pulmonary Fibrosis
Jin Chen, Vincent Ziboh and Shri N. Giri

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1219-1227;
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Modulation of the NMDA Receptor by Cyanide: Enhancement of Receptor-Mediated Responses
Peiwen Sun, Stanley G. Rane, Palur G. Gunasekar, Joseph L. Borowitz and Gary E. Isom

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1341-1348;
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Trans-2-en-valproic Acid Limits Action Potential Firing Frequency in Mouse Central Neurons in Cell Culture
Artur W. Wamil, Wolfgang Löscher and Michael J. McLean

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1349-1356;
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In Vitro Characterization of Botulinum Toxin Types A, C and D Action on Human Tissues: Combined Electrophysiologic, Pharmacologic and Molecular Biologic Approaches
J. A. Coffield, N. Bakry, R.-d. Zhang, J. Carlson, L. G. Gomella and L. L. Simpson

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1489-1498;

CHEMOTHERAPY/GENE THERAPY

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Effect of Nucleoside Analogs on Neurite Regeneration and Mitochondrial DNA Synthesis in PC-12 Cells
Lixin Cui, Luisa Locatelli, Meng-Yu Xie and Jean-Pierre Sommadossi

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1228-1234;
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Accumulation of Liposomal Lipid and Encapsulated Doxorubicin in Murine Lewis Lung Carcinoma: The Lack of Beneficial Effects by Coating Liposomes with Poly(ethylene glycol)
Michael J. Parr, Dana Masin, Pieter R. Cullis and Marcel B. Bally

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1319-1327;
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The Role of Tumor-Associated Macrophages in the Delivery of Liposomal Doxorubicin to Solid Murine Fibrosarcoma Tumors
Lawrence D. Mayer, Graeme Dougherty, Troy O. Harasym and Marcel B. Bally

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1406-1414;

DRUG METABOLISM AND DISPOSITION

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Temocaprilat, a Novel Angiotensin-Converting Enzyme Inhibitor, is Excreted in Bile via an ATP-dependent Active Transporter (cMOAT) That is Deficient in Eisai Hyperbilirubinemic Mutant Rats (EHBR)
Hitoshi Ishizuka, Kumiko Konno, Hideo Naganuma, Kunihiro Sasahara, Yukinori Kawahara, Kayoko Niinuma, Hiroshi Suzuki and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1304-1311;
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The Effect of Caffeine and Caffeine Analogs on Rat Liver Phosphorylase a Activity
Nacide Ercan-Fang and Frank Q. Nuttall

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1312-1318;
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Pharmacokinetics of Troglitazone, an Antidiabetic Agent: Prediction of In Vivo Stereoselective Sulfation and Glucuronidation from In Vitro Data
Takashi Izumi, Kazuko Hosiyama, Sachiko Enomoto, Kunihiro Sasahara and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1392-1400;
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Differential Inductive and Suppressive Effects of Endotoxin and Particulate Irritants on Hepatic and Renal Cytochrome P-450 Expression
Marion B. Sewer, Dennis R. Koop and Edward T. Morgan

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1445-1454;
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Nitric Oxide Differentially Affects Constitutive Cytochrome P450 Isoforms in Rat Liver
Oleg Khatsenko and Yutaka Kikkawa

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1463-1470;

GASTROINTESTINAL PHARMACOLOGY

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SDZ HTF 919 Stimulates Canine Colonic Motility and Transit In Vivo
Adrienne Nguyen, Michael Camilleri, Louis J. Kost, Alejandro Metzger, Michael G. Sarr, Russell B. Hanson, Sara L. Fett and Alan R. Zinsmeister

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1270-1276;

NEUROPHARMACOLOGY

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Dynorphin A (1–8) Analog, E-2078, Is Stable in Human and Rhesus Monkey Blood
Jim Yu, Eduardo R. Butelman, James H. Woods, Brian T. Chait and Mary Jeanne Kreek

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1147-1151;
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Beta Adrenergic Sensitization of γ-Aminobutyric Acid Receptors to Ethanol Involves a Cyclic AMP/Protein Kinase A Second-Messenger Mechanism
Ronald K. Freund and Michael R. Palmer

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1192-1200;
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The Entry of [d-Penicillamine^2,5]Enkephalin into the Central Nervous System: Saturation Kinetics and Specificity
Sarah A. Thomas, Thomas J. Abbruscato, Victor J. Hruby and Thomas P. Davis

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1235-1240;
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Interactions of (+)- and (−)-8- and 7-Hydroxy-2-(Di-n-Propylamino)tetralin at Human (h)D₃, hD₂and h Serotonin_1AReceptors and Their Modulation of the Activity of Serotoninergic and Dopaminergic Neurones in Rats
F. Lejeune, A. Newman-Tancredi, V. Audinot and M. J. Millan

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1241-1249;
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Neurochemical Effects of 3-[1-(Phenylmethyl)-4-Piperidinyl]-1-(2,3,4,5-Tetrahydro-1H-1-Benzazepin-8-yl)-1-Propanone Fumarate (TAK-147), a Novel Acetylcholinesterase Inhibitor, in Rats
Keisuke Hirai, Koki Kato, Takahiro Nakayama, Hitomi Hayako, Yuji Ishihara, Giichi Goto and Masaomi Miyamoto

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1261-1269;
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Nicotine-Induced Inhibition of Neuronal Phospholipase A2
Philippe Marin, Brigitte Hamon, Jacques Glowinski and Joël Prémont

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1277-1283;
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Barbiturate-Like Actions of the Propanediol Dicarbamates Felbamate and Meprobamate
Jong M. Rho, Sean D. Donevan and Michael A. Rogawski

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1383-1391;
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A Crucial Role of the α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Subtype of Glutamate Receptors in Piriform and Perirhinal Cortex for the Initiation and Propagation of Limbic Motor Seizures
Alfonso Tortorella, Toivo Halonen, Niaz Sahibzada and Karen Gale

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1401-1405;
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Lobeline and Nicotine Evoke [³H]Overflow from Rat Striatal Slices Preloaded with [³H]Dopamine: Differential Inhibition of Synaptosomal and Vesicular [³H]Dopamine Uptake
Lihong Teng, Peter A. Crooks, Patricia K. Sonsalla and Linda P. Dwoskin

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1432-1444;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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Mechanism of Action of Leukotriene D₄ on Guinea Pig Tracheal Smooth Muscle Cells: Roles of Ca⁺⁺ Influx and Intracellular Ca⁺⁺ Release
Daniela Dumitriu, Stéphane Prié, Sylvie G. Bernier, Gaétan Guillemette and Pierre Sirois

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1357-1365;
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Involvement of Thromboxane A₂ and Histamine in Experimental Allergic Rhinitis of Guinea Pigs
M. Yamasaki, T. Matsumoto, S. Fukuda, T. Nakayama, H. Nagaya and Y. Ashida

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1471-1479;

PULMONARY PHARMACOLOGY

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Role of Soluble Guanylyl Cyclase in the Relaxations to a Nitric Oxide Donor and to Nonadrenergic Nerve Stimulation in Guinea Pig Trachea and Human Bronchus
James L. Ellis

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1215-1218;
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ABT-761 Attenuates Bronchoconstriction and Pulmonary Inflammation in Rodents
Randy L. Bell, Richard R. Harris, Peter E. Malo, Jennifer B. Bouska, Thomas K. Shaughnessy, Keren I. Hulkower, Clint D. W. Brooks and George W. Carter

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1366-1373;

RENAL PHARMACOLOGY

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Comparison of the Water Diuretic Activity of KappaReceptor Agonists and a Vasopressin Receptor Antagonist in Dogs
David P. Brooks, Maurizio Valente, Giuseppe Petrone, P. Dennis Depalma, Massimo Sbacchi and Geoffrey D. Clarke

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1176-1183;

TOXICOLOGY

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Protein Phosphatase in Neuroblastoma Cells: [³H]Cantharidin Binding Site in Relation to Cytotoxicity
Charles W. Laidley, Ephraim Cohen and John E. Casida

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1152-1158;
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Cyclosporine A-Induced Oxidative Stress in Rat Hepatocytes
Armin Wolf, Christian-F. Trendelenburg, Carmen Diez-Fernandez, Pilar Prieto, Simone Houy, Wolfgang E. Trommer and André Cordier

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1328-1334;
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The Role of Thiols in Protecting against Simultaneous Toxicity of Menadione to Platelet Plasma and Intracellular Membranes
Youn-Sook Cho, Mee-Jeong Kim, Joo-Young Lee and Jin-Ho Chung

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1335-1340;
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Induction of Hepatic Heme Oxygenase and Changes in Cytochrome P-450s in Response to Oxidative Stress Produced by Stilbenes and Stilbene Oxides in Rats
Takiko Oguro, Eiko Kaneko, Satoshi Numazawa, Susumu Imaoka, Yoshihiko Funae and Takemi Yoshida

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1455-1462;
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Pharmacokinetics and Distribution of a ³³P-labeled Anti-Human Immunodeficiency Virus Oligonucleotide (AR177) after Single- and Multiple-Dose Intravenous Administration to Rats
Thomas L. Wallace, Scott A. Bazemore, Karsten Holm, Peter M. Markham, J. Paul Shea, Nilabh Chaudhary and Paul A. Cossum

Journal of Pharmacology and Experimental Therapeutics March 1997, 280 (3) 1480-1488;

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Table of Contents

THE 1996 ASPET OTTO KRAYER AWARD LECTURE

ANALGESIA AND DRUGS OF ABUSE

AUTONOMIC PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR PHARMACOLOGY

CELLULAR AND MOLECULAR PHARMACOLOGY

CHEMOTHERAPY/GENE THERAPY

DRUG METABOLISM AND DISPOSITION

GASTROINTESTINAL PHARMACOLOGY

NEUROPHARMACOLOGY

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

PULMONARY PHARMACOLOGY

RENAL PHARMACOLOGY

TOXICOLOGY

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