Journal of Pharmacology and Experimental Therapeutics: 280 (1)

January 01, 1997; Volume 280,Issue 1

AUTONOMIC PHARMACOLOGY

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Effects of Tamsulosin Metabolites at Alpha-1 Adrenoceptor Subtypes
Katsunari Taguchi, Minori Saitoh, Shuichi Sato, Masaharu Asano and Martin C. Michel

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 1-5;
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M₂ Muscarinic Receptor Inhibition of Agonist-induced Cyclic Adenosine Monophosphate Accumulation and Relaxation in the Guinea Pig Ileum
Rennolds S. Ostrom and Frederick J. Ehlert

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 189-199;
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Kinetic Studies of Desensitization and Resensitization of the Relaxation Response to Beta-2 Adrenoceptor Agonists in Isolated Guinea Pig Trachea
Daniel E. Wachsman, Jill P. Kavaler, István P. Sugár, E. Neil Schachter, Waldemar Gonsiorek and Saul Maayani

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 332-345;

BEHAVIORAL PHARMACOLOGY

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Effects of Strychnine-Insensitive Glycine Receptor Ligands in Rats Discriminating Dizocilpine or Phencyclidine from Saline
Jeffrey M. Witkin, Thomas D. Steele and Lawrence G. Sharpe

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 46-52;
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Discriminative Stimulus Effects of Zolpidem in Pentobarbital-Trained Subjects: I. Comparison with Triazolam in Rhesus Monkeys and Rats
James K. Rowlett and William L. Woolverton

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 162-173;
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Discriminative Stimulus Effects of Zolpidem in Pentobarbital-Trained Subjects: II. Comparison with Triazolam and Caffeine in Humans
Craig R. Rush, Sudhakar Madakasira, Nancy H. Goldman, William L. Woolverton and James K. Rowlett

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 174-188;
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Effects of Negative Allosteric Modulators of γ-Aminobutyric Acid_A Receptors on Complex Behavioral Processes in Monkeys
J. Auta, P. J. Winsauer, W. B. Faust, P. Lambert and J. M. Moerschbaecher

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 316-325;

CARDIOVASCULAR PHARMACOLOGY

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Cardiovascular Effects of Sar-[d-Phe⁸]des-Arg⁹-Bradykinin, a Metabolically Protected Agonist of B₁ Receptor for Kinins, in the Anesthetized Rabbit Pretreated with a Sublethal Dose of Bacterial Lipopolysaccharide
Ritchie Audet, Francis Rioux, Guy Drapeau and François Marceau

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 6-15;
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Effects of Chronic Morphine Treatment on Catecholamines Content and Mechanical Response in the Rat Hearts
J. V. Rabadán, M. V. Milanés and M. L. Laorden

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 32-37;
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Effect of Tachykinin Receptor Inhibition in the Brain on Cardiovascular and Behavioral Responses to Stress
Juraj Culman, Sabine Klee, Christina Ohlendorf and Thomas Unger

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 238-246;
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Ca⁺⁺ Sensitizers Impair Cardiac Relaxation in Failing Human Myocardium
Roger J. Hajjar, Ulrich Schmidt, Patrick Helm and Judith K. Gwathmey

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 247-254;
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Tissue and Species Variation in the Vascular Receptor Binding of³H-P1075, a Potent K_ATP Opener Vasodilator
Nicole R. Higdon, Sajida A. Khan, Lewis V. Buchanan and Kaushik D. Meisheri

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 255-260;
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Mechanisms of the Contractile Effects of Levosimendan in the Mammalian Heart
Peter Bokník, Joachim Neumann, Grit Kaspareit, Wilhelm Schmitz, Hasso Scholz, Ute Vahlensieck and Norbert Zimmermann

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 277-283;
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Adenosine A₂ Receptor Activation Attenuates Reperfusion Injury by Inhibiting Neutrophil Accumulation, Superoxide Generation and Coronary Endothelial Adherence
James E. Jordan, Zhi-Qing Zhao, Hiroki Sato, Spencer Taft and Jakob Vinten-Johansen

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 301-309;
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Vascular and Hemodynamic Differences between Organic Nitrates and Nitrites
John Anthony Bauer, Tim Nolan and Ho-Leung Fung

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 326-331;
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HR 720, A Novel Angiotensin Receptor Antagonist Inhibits the Angiotensin II-Induced Trophic Effects, Fibronectin Release and Fibronectin-EIIIA⁺ Expression in Rat Aortic Vascular Smooth Muscle Cells in Vitro
F. W. Dunn, M.-H. Roux, F. Farhadian, K. Sabri, C. Ossart, J. L. Samuel, L. Rappaport and G. Hamon

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 447-453;
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Mechanisms of the Regional Hemodynamic Effects of a μ-Opioid Receptor Agonist Microinjected into the Hypothalamic Paraventricular Nuclei of Conscious Unrestrained Rats
Hélène Bachelard, Maryse Pître and Andrée Lessard

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 460-470;
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Inhibition by Hydroxyl Radicals of Calcitonin Gene-Related Peptide-Mediated Neurogenic Vasorelaxation in Isolated Canine Lingual Artery
Masahiro Norisue, Kazuo Todoki and Eiichiro Okabe

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 492-500;

CELLULAR AND MOLECULAR PHARMACOLOGY

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Modulation of ATP-Sensitive and Large-Conductance Ca⁺⁺-Activated K⁺ Channels by Zeneca ZD6169 in Guinea Pig Bladder Smooth Muscle Cells
Shiling Hu and Helen S. Kim

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 38-45;
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Cloning, Expression and Pharmacological Characterization of Rabbit Adenosine A₁ and A₃ Receptors
Roger J. Hill, Joseph J. Oleynek, Christopher F. Hoth, M. A. Ravi Kiron, Weifan Weng, Ronald T. Wester, W. Ross Tracey, Delvin R. Knight, R. Allan Buchholz and Scott P. Kennedy

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 122-128;
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Pharmacological Characterization of Recombinant Human Neuronal Nicotinic Acetylcholine Receptors hα2β2, hα2β4, hα3β2, hα3β4, hα4β2, hα4β4 and hα7 Expressed in Xenopus Oocytes
Laura E. Chavez-Noriega, James H. Crona, Mark S. Washburn, Arturo Urrutia, Kathryn J. Elliott and Edwin C. Johnson

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 346-356;
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Inhibition of DNA Synthesis by Aspirin in Swiss 3T3 Fibroblasts
Esther Castaño, Mireia Dalmau, Mercè Martí, Félix Berrocal, Ramon Bartrons and Joan Gil

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 366-372;
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Epileptic Activity Prevents Synapse Formation of Hippocampal Mossy Fibers via L-Type Calcium Channel Activation In Vitro
Yuji Ikegaya, Masatoshi Yoshida, Hiroshi Saito and Nobuyoshi Nishiyama

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 471-476;
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Nicorandil Activates Glibenclamide-Sensitive K⁺Channels in Smooth Muscle Cells of Pig Proximal Urethra
Noriyoshi Teramoto and Alison F. Brading

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 483-491;

CHEMOTHERAPY/GENE THERAPY

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Body Distribution of Free, Liposomal and Nanoparticle-Associated Mitoxantrone in B16-Melanoma-Bearing Mice
R. Reszka, P. Beck, I. Fichtner, M. Hentschel, J. Richter and J. Kreuter

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 232-237;
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Correlation Between In Vitro and In Vivo Activity of Amoxicillin Against Streptococcus pneumoniae in a Murine Pneumonia Model
Pierre Moine, Jean-Xavier Mazoit, Jean-Pierre Bédos, Éric Vallée and Esther Azoulay-Dupuis

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 310-315;

DRUG METABOLISM AND DISPOSITION

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Effect of Flow on First-Pass Metabolism of Drugs: Single Pass Studies on 4-Methylumbelliferone Conjugation in the Serially Perfused Rat Intestine and Liver Preparations
Jinping Chen and K. Sandy Pang

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 24-31;
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Selective Centrilobular Expression of the Aryl Hydrocarbon Receptor in Rat Liver
Kai O. Lindros, Teija Oinonen, Inger Johansson and Magnus Ingelman-Sundberg

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 506-511;

ENDOCRINE PHARMACOLOGY

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Hypocholesterolemic Activity of Raloxifene (LY139481): Pharmacological Characterization as a Selective Estrogen Receptor Modulator
Raymond F. Kauffman, William R. Bensch, Roger E. Roudebush, Harlan W. Cole, James S. Bean, D. Lynn Phillips, Amy Monroe, George J. Cullinan, Andrew L. Glasebrook and Henry U. Bryant

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 146-153;
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Dynorphin A_1–13 Stimulates Ovine Fetal Pituitary-Adrenal Function through a Novel Nonopioid Mechanism
Cindy C. Taylor, Dunli Wu, Yi Soong, Jenny S. Yee and Hazel H. Szeto

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 416-421;

GASTROINTESTINAL PHARMACOLOGY

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Effect of GK-128 [2-[(2-Methylimidazol-1-yl)methyl]benzo[f]thiochromen-1-one Monohydrochloride Hemihydrate], a Selective 5-Hydroxytryptamine₃ Receptor Antagonist, on Colonic Function in Rats
Chika Ito, Yoshihiko Isobe, Reiko Kawamura, Yoichi Kiuchi, Katsuharu Tsuchida and Shohei Higuchi

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 67-72;
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Dual Excitatory and Inhibitory Effect of Nitric Oxide on Peristalsis in the Guinea Pig Intestine
P. Holzer, I.Th. Lippe, A. Lotfi Tabrizi, L. Lénárd and L. Barthó

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 154-161;
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Absorption and Excretion of Undegradable Peptides: Role of Lipid Solubility and Net Charge
J. R. Pappenheimer, M. L. Karnovsky and J. E. Maggio

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 292-300;

IMMUNOPHARMACOLOGY

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Protection from T Cell-Mediated Murine Liver Failure by Phosphodiesterase Inhibitors
Florian Gantner, Sabine Küsters, Albrecht Wendel, Armin Hatzelmann, Christian Schudt and Gisa Tiegs

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 53-60;
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Role of Corticosterone in the Enhancement of the Antibody Response after Acute Cocaine Administration
Eric D. Stanulis, Ray A. Matulka, Stephen D. Jordan, John A. Rosecrans and Michael P. Holsapple

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 284-291;
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Hydroxyurea Induces the Gene Expression and Synthesis of Proinflammatory Cytokines In Vivo
Pierluigi Navarra, Ursula Grohmann, Giuseppe Nocentini, Giuseppe Tringali, Paolo Puccetti, Carlo Riccardi and Paolo Preziosi

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 477-482;

NEUROPHARMACOLOGY

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Chronic Morphine Treatment of Guinea Pigs Induces Nonspecific Sensitivity Changes in the Nucleus Tractus Solitarius In Vitro
C. J. Malanga, Jianzhong Meng, William W. Fleming and David A. Taylor

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 16-23;
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Inhibition of Lipopolysaccharide-Induced Nitric Oxide and Cytokine Production by Ultralow Concentrations of Dynorphins in Mixed Glia Cultures
Ling-Yuan Kong, Michael K. McMillian, Pearlie M. Hudson, Lei Jin and Jau-Shyong Hong

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 61-66;
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Psychopharmacological Profile of Amisulpride: An Antipsychotic Drug with Presynaptic D₂/D₃ Dopamine Receptor Antagonist Activity and Limbic Selectivity
Gh. Perrault, R. Depoortere, E. Morel, D. J. Sanger and B. Scatton

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 73-82;
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Neurochemical Characteristics of Amisulpride, an Atypical Dopamine D₂/D₃ Receptor Antagonist with Both Presynaptic and Limbic Selectivity
H. Schoemaker, Y. Claustre, D. Fage, L. Rouquier, K. Chergui, O. Curet, A. Oblin, F. Gonon, C. Carter, J. Benavides and B. Scatton

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 83-97;
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Decreases in Evoked Overflow of Dopamine in Rat Striatum after Neurotoxic Doses of Methamphetamine
Wayne A. Cass

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 105-113;
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Chronic Cocaine Enhances γ-Aminobutyric Acid and Glutamate Release by Altering Presynaptic and not Postsynaptic γ-Aminobutyric Acid_B Receptors within the Rat Dorsolateral Septal Nucleus
Shingo Shoji, Debra Simms, Wesley C. McDaniel and Joel P. Gallagher

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 129-137;
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Effect of Prenatal Fluoxetine (Prozac) Exposure on Brain Serotonin Neurons in Prepubescent and Adult Male Rat Offspring
Theresa M. Cabrera-Vera, Francisca Garcia, Wilfred Pinto and George Battaglia

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 138-145;
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Neuroleptic-Induced Mitochondrial Enzyme Alterations in the Rat Brain
Jonathan A. Prince, Mohammed S. Yassin and Lars Oreland

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 261-267;
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Persistent Spontaneous Oral Dyskinesias in Haloperidol-Withdrawn Rats Neonatally Lesioned with 6-Hydroxydopamine: Absence of an Association with the B _max for [³H]Raclopride Binding to Neostriatal Homogenates
Nuo-Yu Huang, Richard M. Kostrzewa, Chuanfu Li, Kenneth W. Perry and Ray W. Fuller

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 268-276;
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N-Methyl-d-aspartate Antagonist Activity of α- and β-Sulfallorphans
Vijay K. Shukla and Simon Lemaire

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 357-365;
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Pharmacological Characterization of SIB-1765F: A Novel Cholinergic Ion Channel Agonist
Aida I. Sacaan, Richard T. Reid, Emily M. Santori, Pamala Adams, Lucia D. Correa, Lorrence S. Mahaffy, Leo Bleicher, Nicholas D. P. Cosford, Kenneth A. Stauderman, Ian A. McDonald, Tadimeti S. Rao and G. Kenneth Lloyd

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 373-383;
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Effects of a Novel Cholinergic Ion Channel Agonist SIB-1765F on Locomotor Activity in Rats
Frédérique Menzaghi, Kevin T. Whelan, Victoria B. Risbrough, Tadimeti S. Rao and G. Kenneth Lloyd

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 384-392;
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Interactions between a Novel Cholinergic Ion Channel Agonist, SIB-1765F and L-DOPA in the Reserpine Model of Parkinson’s Disease in Rats
Frédérique Menzaghi, Kevin T. Whelan, Victoria B. Risbrough, Tadimeti S. Rao and G. Kenneth Lloyd

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 393-401;
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Blood-Brain Barrier Permeability and Bioavailability of a Highly Potent and μ-Selective Opioid Receptor Antagonist, CTAP: Comparison with Morphine
Thomas J. Abbruscato, Sarah A. Thomas, Victor J. Hruby and Thomas P. Davis

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 402-409;
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Structure-Internalization Relationship for Adsorptive-Mediated Endocytosis of Basic Peptides at the Blood-Brain Barrier
Ikumi Tamai, Yoshimichi Sai, Hiroyuki Kobayashi, Makoto Kamata, Tateaki Wakamiya and Akira Tsuji

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 410-415;
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(2S,4R)-4-Methylglutamic Acid (SYM 2081): A Selective, High-Affinity Ligand for Kainate Receptors
L.-M. Zhou, Z.-Q. Gu, A. M. Costa, K. A. Yamada, P. E. Mansson, T. Giordano, P. Skolnick and K. A. Jones

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 422-427;
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Activation of the Recombinant Human α₇ Nicotinic Acetylcholine Receptor Significantly Raises Intracellular Free Calcium
O. Delbono, M. Gopalakrishnan, M. Renganathan, L. M. Monteggia, M. L. Messi and J. P. Sullivan

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 428-438;
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(+)MK-801 Does Not Prevent MPTP-Induced Loss of Nigral Neurons in Mice
Piu Chan, Donato A. Di Monte, J. William Langston and Ann Marie Janson

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 439-446;
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Chronic Morphine Treatment Increases StimulatoryBeta-2 Adrenoceptor Signaling in A431 Cells Stably Expressing the Mu Opioid Receptor
Hermann Ammer and Rüdiger Schulz

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 512-520;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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Phorbol Ester Enhancement of IL-3-Dependent Proliferation of Primitive Hematopoietic Progenitors of Mice in Culture
Manabu Musashi, Keisuke Sakurada, Ken-Ichi Kawamura, Hiroshi Iwasaki, Yuzo Tsuda, Masanobu Kobayashi, Makie Sasaki, Keiko Kato, Eiji Tanaka, Tetsuo Sudo, Masahiro Asaka and Tamotsu Miyazaki

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 225-231;
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Effect of Aspirin Plus Dipyridamole on the Retinal Vascular Pattern in Experimental Diabetes Mellitus
J. P. De La Cruz, A. Moreno, M. Muñoz, J. M. García Campos and F. Sánchez De La Cuesta

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 454-459;

PULMONARY PHARMACOLOGY

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Rupatadine, a New Potent, Orally Active Dual Antagonist of Histamine and Platelet-Activating Factor (PAF)
Manuel Merlos, Marta Giral, Dolors Balsa, Rosa Ferrando, Mireia Queralt, Anna Puigdemont, Julián Garcı́a-Rafanell and Javier Forn

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 114-121;
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The Influence of Endogenous Catecholamines on the Inhibitory Effects of Rolipram Against Early- and Late-Phase Response to Antigen in the Guinea Pig
David C. Underwood, Jane K. Matthews, Ruth R. Osborn, Steven Bochnowicz and Theodore J. Torphy

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 210-219;

RENAL PHARMACOLOGY

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Renal and Cerebrospinal Fluid Formation Pharmacology of a High Molecular Weight Carbonic Anhydrase Inhibitor
Thomas H. Maren, Curtis W. Conroy, George C. Wynns and David R. Godman

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 98-104;
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Reabsorption of the Nephrotoxin Ochratoxin A Along the Rat Nephron In Vivo
Matthias Zingerle, Stefan Silbernagl and Michael Gekle

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 220-224;

TOXICOLOGY

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UDP-Glucuronosyltransferase-mediated Protection Against In Vitro DNA Oxidation and Micronucleus Formation Initiated by Phenytoin and Its Embryotoxic Metabolite 5-(p-Hydroxyphenyl)-5-phenylhydantoin
Perry M. Kim, Louise M. Winn, Toufan Parman and Peter G. Wells

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 200-209;
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Covalent Binding of Acetaminophen to N-10-Formyl-Tetrahydrofolate Dehydrogenase in Mice
Neil R. Pumford, N. Christine Halmes, Brian M. Martin, Robert J. Cook, Conrad Wagner and Jack A. Hinson

Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 501-505;

Erratum

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Correction for vol. 279, p. 247
Journal of Pharmacology and Experimental Therapeutics January 1997, 280 (1) 520;

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Table of Contents

AUTONOMIC PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR PHARMACOLOGY

CELLULAR AND MOLECULAR PHARMACOLOGY

CHEMOTHERAPY/GENE THERAPY

DRUG METABOLISM AND DISPOSITION

ENDOCRINE PHARMACOLOGY

GASTROINTESTINAL PHARMACOLOGY

IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

PULMONARY PHARMACOLOGY

RENAL PHARMACOLOGY

TOXICOLOGY

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