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Abstract

Functional effects of GDNF in normal rat striatum: presynaptic studies using in vivo electrochemistry and microdialysis.

M A Hebert, C G Van Horne, B J Hoffer and G A Gerhardt
Journal of Pharmacology and Experimental Therapeutics December 1996, 279 (3) 1181-1190;
M A Hebert
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C G Van Horne
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B J Hoffer
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G A Gerhardt
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Abstract

The functional effects of a single dual-site intranigral administration (10 micrograms) of glial cell line-derived neurotrophic factor (GDNF) on dopamine (DA) neurons in the basal ganglia of young Fischer 344 rats were investigated. A combination of behavioral, in vivo electrochemical, microdialysis and high-performance liquid chromatography methods were used to study the effects of this novel peptide. Behaviorally, significant changes in spontaneous locomotor activity were found 1 week, but not 3 weeks, after GDNF treatment. However, the velocity of movements was increased in the GDNF-treated animals 3 weeks after GDNF administration, a result that corresponded to significant enhancement of stimulus-evoked release of DA. Two-fold increases in potassium-evoked DA overflow were seen throughout the striatum by means of high-speed chronoamperometry 3 weeks after GDNF injection. No significant change in basal levels of DA was measured by microdialysis, although both potassium-evoked and d-amphetamine-induced DA overflow were significantly increased 3 weeks after treatment. Finally, significant changes in whole-tissue levels of DA were seen in the substantia nigra 1 week, but not 3 weeks, after GDNF administration. These data represent the first studies demonstrating that GDNF has long-lasting functional presynaptic effects on DA-containing neurons in the rat striatum.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 279, Issue 3
1 Dec 1996
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Abstract

Functional effects of GDNF in normal rat striatum: presynaptic studies using in vivo electrochemistry and microdialysis.

M A Hebert, C G Van Horne, B J Hoffer and G A Gerhardt
Journal of Pharmacology and Experimental Therapeutics December 1, 1996, 279 (3) 1181-1190;

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Abstract

Functional effects of GDNF in normal rat striatum: presynaptic studies using in vivo electrochemistry and microdialysis.

M A Hebert, C G Van Horne, B J Hoffer and G A Gerhardt
Journal of Pharmacology and Experimental Therapeutics December 1, 1996, 279 (3) 1181-1190;
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