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Abstract

5-Hydroxytryptamine-induced synovial plasma extravasation is mediated via 5-hydroxytryptamine2A receptors on sympathetic efferent terminals.

P A Pierce, G X Xie, S J Peroutka, P G Green and J D Levine
Journal of Pharmacology and Experimental Therapeutics October 1995, 275 (1) 502-508;
P A Pierce
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G X Xie
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S J Peroutka
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P G Green
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J D Levine
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Abstract

5-Hydroxytryptamine (5-HT) is known to act in peripheral tissues to produce pain and inflammation, yet the mechanisms underlying 5-HT-induced inflammation have not been well studied. The present study uses a rat knee joint model of inflammation (synovial plasma extravasation) and molecular biological techniques to determine the site of action of 5-HT and the specific 5-HT receptor subtype mediating synovial 5-HT-induced plasma extravasation. 5-HT (1 microM) stimulates synovial plasma extravasation 7-fold above base-line levels. Surgical lumbar sympathectomy, but not C-fiber depletion by neonatal capsaicin, dramatically reduces 5-HT-induced synovial plasma extravasation (P < .001), indicating that sympathetic efferents mediate this effect. Polymerase chain reaction amplification of 5-HT receptor cDNA demonstrates that 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A and 5-HT3, but not the 5-HT2C, receptor subtypes are present in lumbar sympathetic ganglia. With selective ligands for these receptor subtypes, we demonstrate that 5-HT-induced synovial plasma extravasation is mediated via the 5-HT2A receptor. These findings suggest a role for 5-HT2A antagonists in various synovial inflammatory pain states.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 275, Issue 1
1 Oct 1995
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Abstract

5-Hydroxytryptamine-induced synovial plasma extravasation is mediated via 5-hydroxytryptamine2A receptors on sympathetic efferent terminals.

P A Pierce, G X Xie, S J Peroutka, P G Green and J D Levine
Journal of Pharmacology and Experimental Therapeutics October 1, 1995, 275 (1) 502-508;

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Abstract

5-Hydroxytryptamine-induced synovial plasma extravasation is mediated via 5-hydroxytryptamine2A receptors on sympathetic efferent terminals.

P A Pierce, G X Xie, S J Peroutka, P G Green and J D Levine
Journal of Pharmacology and Experimental Therapeutics October 1, 1995, 275 (1) 502-508;
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