Journal of Pharmacology and Experimental Therapeutics: 267 (3)

December 01, 1993; Volume 267,Issue 3

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Interactions of nonprostanoid trimetoquinol analogs with thromboxane A2/prostaglandin H2 receptors in human platelets, rat vascular endothelial cells and rat vascular smooth muscle cells.
Y Shin, K J Romstedt, D D Miller and D R Feller

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1017-1023;
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Inhibition of nitric oxide synthase by a superoxide generating system.
A Rengasamy and R A Johns

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1024-1027;
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Endothelin inhibits vasopressin action in rat inner medullary collecting duct via the ETB receptor.
R M Edwards, E J Stack, M Pullen and P Nambi

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1028-1033;
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Multiple-dose lorazepam kinetics: shuttling of lorazepam glucuronide between the circulation and the gut during day- and night-time dosing intervals in response to feeding.
A Chaudhary, R A Lane, D Woo and R J Herman

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1034-1038;
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Cimetidine uptake and interactions with cationic drugs in freshly isolated proximal tubular cells of the rat.
S P Boom and F G Russel

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1039-1044;
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Effects of extracellular magnesium manipulation on reperfusion-induced arrhythmias and myocardial ion shifts in isolated ischemic reperfused rat hearts.
A Tosaki, P Szerdahelyi, R M Engelman and D K Das

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1045-1053;
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Functional evidence that [3H]acetylcholine and [3H]noradrenaline release from guinea pig ileal myenteric plexus and noradrenergic terminals is modulated by different presynaptic alpha-2 adrenoceptor subtypes.
C Blandizzi, G Tarkovacs, G Natale, M Del Tacca and E S Vizi

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1054-1060;
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Quantification of effect delay and acute tolerance development to morphine in the rat.
M Gårdmark, M Ekblom, R Bouw and M Hammarlund-Udenaes

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1061-1067;
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Effect of valproic acid on glycine conjugation of benzoic acid.
Z Gregus, T Fekete, F Varga and C D Klaassen

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1068-1075;
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Attenuation of proarrhythmias related to delayed repolarization by low-dose lidocaine in the anesthetized rabbit.
L Carlsson, L Drews, G Duker and G Schiller-Linhardt

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1076-1080;
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Stereoselective blockade of amphibian epithelial sodium channels by amiloride analogs.
J H Li, A Shaw and S T Kau

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1081-1084;
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Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier.
A Tsuji, A Saheki, I Tamai and T Terasaki

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1085-1090;
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Vascular pharmacodynamics of NG-nitro-L-arginine methyl ester in vitro and in vivo.
Y X Wang, C I Poon and C C Pang

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1091-1099;
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The P1-purinoceptors that mediate the prejunctional inhibitory effect of adenosine on capsaicin-sensitive nonadrenergic noncholinergic neurotransmission in the rat mesenteric arterial bed are of the A1 subtype.
A Rubino, V Ralevic and G Burnstock

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1100-1104;
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Dopaminergic functional supersensitivity: effects of chronic L-dopa and carbidopa treatment in an animal model of Parkinson's disease.
M A Hossain and N Weiner

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1105-1111;
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Inhibition of endothelial nitric oxide synthase by ebselen. Prevention by thiols suggests the inactivation by ebselen of a critical thiol essential for the catalytic activity of nitric oxide synthase.
A Zembowicz, R J Hatchett, W Radziszewski and R J Gryglewski

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1112-1118;
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Tyrphostin attenuates platelet-derived growth factor-induced contraction in aortic smooth muscle through inhibition of protein tyrosine kinase(s).
M D Sauro and B Thomas

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1119-1125;
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Binding and functional characterization of alpha-2 adrenergic receptor subtypes on pig vascular endothelium.
C S Bockman, W B Jeffries and P W Abel

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1126-1133;
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Ionophoretic-like properties of ketorolac for calcium.
R Chàvez, C Bravo, C Zazueta, J Pichardo, A Uribe, N Corona, H Reyes-Vivas, C González and E Chàvez

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1134-1139;
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Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase.
J L Boyer, E R Lazarowski, X H Chen and T K Harden

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1140-1146;
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Effects of isoenzyme-selective inhibitors of cyclic nucleotide phosphodiesterase on microvascular leak in guinea pig airways in vivo.
D Raeburn and J A Karlsson

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1147-1152;
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Inhibition of norepinephrine release from rat cortex slices by opioids: differences among agonists in sensitivities to antagonists suggest receptor heterogeneity.
K W Kim and B M Cox

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1153-1160;
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Migrating motor complex of the intestine and absorption of a biliary excreted drug in the dog.
N Priymenko, J P Ferre, A Rascol, G Costes and P L Toutain

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1161-1167;
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Differential blockade by tachykinin NK1 and NK2 receptor antagonists of bronchoconstriction induced by direct-acting agonists and the indirect-acting mimetics capsaicin, serotonin and 2-methyl-serotonin in the anesthetized guinea pig.
C K Buckner, N Liberati, D Dea, D Lengel, C Stinson-Fisher, J Campbell, S Miller, A Shenvi and R D Krell

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1168-1175;
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Pharmacological characterization of the pressor response to tachykinins in isolated perfused rat kidney.
Y Chen and D B Hoover

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1176-1180;
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Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats.
P A Cossum, H Sasmor, D Dellinger, L Truong, L Cummins, S R Owens, P M Markham, J P Shea and S Crooke

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1181-1190;
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SC-49992, a mimetic of the peptide arginine-glycine-aspartic acid-phenylalanine that blocks platelet aggregation, enhances recombinant tissue plasminogen activator-induced thrombolysis and prevents reocclusion in a canine model of coronary artery thrombosis.
L P Feigen, N S Nicholson, L W King, J G Campion, F S Tjoeng and S G Panzer-Knodle

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1191-1197;
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Absence of receptor reserve at hippocampal muscarinic autoreceptors which inhibit stimulus-dependent acetylcholine release.
T W Vickroy, W L Malphurs and N C Defiebre

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1198-1204;
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Distinct muscarinic receptors, G proteins and phospholipases in esophageal and lower esophageal sphincter circular muscle.
U D Sohn, K M Harnett, G De Petris, J Behar and P Biancani

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1205-1214;
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Effect of the beta-carboline abecarnil on spinal reflexes in mice and on muscle tone in genetically spastic rats: a comparison with diazepam.
L Turski and D N Stephens

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1215-1220;
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Determination and metabolism of dithiol chelating agents. XV. The meso-2,3-dimercaptosuccinic acid-cysteine (1:2) mixed disulfide, a major urinary metabolite of DMSA in the human, increases the urinary excretion of lead in the rat.
R M Maiorino, M M Aposhian, Z F Xu, Y Li, R L Polt and H V Aposhian

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1221-1226;
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Microdialysis study of zidovudine (AZT) transport in rat brain.
K H Dykstra, A Arya, D M Arriola, P M Bungay, P F Morrison and R L Dedrick

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1227-1236;
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Comparison of thrombin active site and exosite inhibitors and heparin in experimental models of arterial and venous thrombosis and bleeding.
W A Schumacher, T E Steinbacher, C L Heran, S M Seiler, I M Michel and M L Ogletree

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1237-1242;
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An alternative mechanism for the inhibition of cholesterol biosynthesis in HepG2 cells by N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol (MDL 28,815).
W A Van Sickle, P K Wilson, M W Wannamaker, J R Cooper, M A Flanagan, J R McCarthy, P Bey and R L Jackson

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1243-1249;
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The regulation of regional hemodynamics by alpha-1 adrenoceptor subtypes in the conscious rat.
M T Piascik, M S Smith, K W Barron and E E Soltis

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1250-1255;
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Fluoxetine prevents the disruptive effects of fenfluramine on differential-reinforcement-of-low-rate 72-second schedule performance.
J B Richards, K E Sabol and L S Seiden

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1256-1263;
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Activation of voltage-dependent calcium channels in Kupffer cells by chronic treatment with alcohol in the rat.
M Goto, J J Lemasters and R G Thurman

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1264-1268;
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Kappa opioid antagonist effects of systemically administered nor-binaltorphimine in a thermal antinociception assay in rhesus monkeys.
E R Butelman, S S Negus, Y Ai, B R de Costa and J H Woods

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1269-1276;
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Functional role of charybdotoxin-sensitive K+ channels in the resting state of cerebral, coronary and mesenteric arteries of the dog.
M Asano, K Masuzawa-Ito, T Matsuda, Y Suzuki, H Oyama, M Shibuya and K Sugita

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1277-1285;
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Distinct profiles of phosphodiesterase isozymes in cultured cells derived from nonpigmented and pigmented ocular ciliary epithelium.
D C Bode, L T Hamel and M B Wax

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1286-1291;
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Fewer PGE2 and PGF2 alpha receptors in brain synaptosomes of newborn than of adult pigs.
D Y Li, D R Varma, T K Chatterjee, H Fernandez, D Abran and S Chemtob

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1292-1297;
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Methionine synthase inactivation by nitrous oxide during methionine loading of normal human fibroblasts. Homocysteine remethylation as determinant of enzyme inactivation and homocysteine export.
B Christensen and P M Ueland

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1298-1303;
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KF17837 is an A2 adenosine receptor antagonist in vivo.
E K Jackson, W A Herzer and F Suzuki

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1304-1310;
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Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity.
C A Sannerud, R J Marley, S L Serdikoff, A J Alastra, C Cohen and S R Goldberg

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1311-1320;
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Novel anti-inflammatory undecapeptides that contain anisolyated glutamic acid derivatives.
H A Thomas, N Ling, E T Wei, F Berree, A Cobas and H Rapoport

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1321-1326;
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Role of calcium-activated K+ channels in vasodilation induced by nitroglycerine, acetylcholine and nitric oxide.
S A Khan, W R Mathews and K D Meisheri

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1327-1335;
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Immunosuppression by morphine is mediated by central pathways.
M C Hernandez, L R Flores and B M Bayer

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1336-1341;
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(-)-2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin (N-0923), a selective D2 dopamine receptor agonist demonstrates the presence of D2 dopamine receptors in the mouse vas deferens but not in the rat vas deferens.
P L Martin, M Kelly and N J Cusack

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1342-1348;
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Protamine and other polycationic drugs inhibit calcium leak in cardiac cells during metabolic inhibition and free radical exposure.
J R Clague, R Harvey and G A Langer

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1349-1354;
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Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts?
A Tosaki, P Szerdahelyi, R M Engelman and D K Das

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1355-1362;
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Nitric oxide synthase inhibitor inhibits catecholamines release caused by hypogastric sympathetic nerve stimulation.
P Thatikunta, S Chakder and S Rattan

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1363-1368;
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Adenosine activates afferent fibers in the forearm, producing sympathetic stimulation in humans.
F Costa and I Biaggioni

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1369-1374;
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Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells.
V Casolaro, S Meliota, O Marino, V Patella, A de Paulis, G Guidi and G Marone

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1375-1385;
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Effects of verapamil on morphine-induced euphoria, analgesia and respiratory depression in humans.
D B Vaupel, W R Lange and E D London

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1386-1394;
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Suppressed renal response to 2,6-dimethyl clonidine but not clonidine in one kidney-one clip hypertensive rats.
P Li and D D Smyth

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1395-1400;
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Effects of phenelzine and hydralazine on hydrogen peroxide production and proteolysis in human red blood cells.
M Runge-Morris and R F Novak

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1401-1406;
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Rapid reversal of angiotensin I-induced contractions in rat carotid arteries after acute and chronic treatment with the angiotensin-converting enzyme inhibitor, 3-[(5-amino-1-carboxy-1S-pentyl)amino]2,3,4,5-tetrahydro-2-oxo- 3S-1H-1-benzazepena-1-acetic acid (CGS 16617).
G B Weiss, B Sturm and N R Levens

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1407-1413;
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Modulation of the developing rat sympathetic GABAA receptor by Zn++, benzodiazepines, barbiturates and ethanol.
L G Aguayo and J M Alarcón

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1414-1422;
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Beta adrenoceptor blockade in rabbit inhibits the renin-releasing effect of AT1 receptor antagonist losartan.
A F Hajj-Ali and P C Wong

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1423-1427;
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Brain acidosis induced by hypercarbic ventilation attenuates focal ischemic injury.
R P Simon, M Niro and R Gwinn

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1428-1431;
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2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neurotransmission.
A M Andrews and D L Murphy

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1432-1439;
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Gender-associated differences in rat renal tubular amantadine transport and absence of stereoselective transport inhibition by quinine and quinidine in distal tubules.
L T Wong, M R Escobar, D D Smyth and D S Sitar

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1440-1444;
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Dopamine and serotonin release-regulating autoreceptor sensitivity in A9/A10 cell body and terminal areas after withdrawal of rats from continuous infusion of cocaine.
N H Chen and M E Reith

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1445-1453;
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Influence of previous exposure to levodopa on the interaction between dizocilpine and dopamine D1 and D2 agonists in rats with 6-hydroxydopamine-induced lesions.
R C Boldry, T N Chase and T M Engber

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1454-1459;
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Prenatal nicotine exposure evokes changes in the incidence and degree of fetal electrocortical activation.
M E McNerney and H H Szeto

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1460-1469;
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Effects of buprenorphine and naltrexone on reinstatement of cocaine-reinforced responding in rats.
S D Comer, S T Lac, L K Curtis and M E Carroll

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1470-1477;
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Pharmacological characterization of the novel cholinomimetic L-689,660 at cloned and native brain muscarinic receptors.
P Aagaard and M McKinney

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1478-1483;
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Cholinergic drugs regulate passive avoidance performance via the amygdala.
P Riekkinen, M Riekkinen and J Sirviö

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1484-1492;
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Nonadrenergic imidazoline binding sites on human platelets.
J E Piletz and K Sletten

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1493-1502;
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Angiotensin-converting enzyme inhibition during development alters calcium regulation in adult hypertensive rats.
O Traub and R C Webb

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1503-1508;
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Chloride dependent intracellular pH increase induced by bepridil in human red blood cells: a possible involvement in correction of ischemic acidosis.
H Kovacic, P Gallice, M Sarrazin and A Crevat

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1509-1514;
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MK-801 temporarily prevents MPTP-induced acute dopamine depletion and MPP+ elimination in the mouse striatum.
P Chan, J W Langston and D A Di Monte

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1515-1520;
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Characterization of angiotensin II receptors in smooth muscle preparations of the guinea pig in vitro.
E Leung, J M Rapp, L K Walsh, K D Zeitung and R M Eglen

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1521-1528;
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Biological activity of S-nitrosothiols: the role of nitric oxide.
W R Mathews and S W Kerr

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1529-1537;
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Cardiovascular, thermal and behavioral sensitization to methamphetamine in freely moving rats.
K Yoshida, A Morimoto, T Makisumi and N Murakami

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1538-1543;
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YM934, a novel K+ channel opener, activates ATP-sensitive K+ channels in cardiac myocytes.
M Yamada, A Terzic, I Findlay, A Jahangir, W K Shen and Y Kurachi

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1544-1549;
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Tumor necrosis factor-alpha mediates endotoxin-induced lung injury in platelet activating factor-primed rats.
R Rabinovici, P J Bugelski, K M Esser, L M Hillegass, D E Griswold, J Vernick and G Feuerstein

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1550-1557;
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Delta 9-tetrahydrocannabinol inhibition of tumor necrosis factor-alpha: suppression of post-translational events.
K Fischer-Stenger, D A Dove Pettit and G A Cabral

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1558-1565;
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IL-1 beta modulates the concanavalin-A-induced expression of proenkephalin A mRNA in murine thymocytes.
K M Linner, S E Nicol and B M Sharp

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1566-1572;
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D2 dopamine receptor stimulation of mitogenesis in transfected Chinese hamster ovary cells: relationship to dopamine stimulation of tyrosine phosphorylations.
M E Lajiness, C L Chio and R M Huff

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1573-1581;
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D1 and D2 dopamine receptor turnover and D2 messenger RNA levels in the neuroleptic-responsive and the neuroleptic nonresponsive lines of mice.
Y Qian, B Hitzemann, G L Yount, J D White and R Hitzemann

Journal of Pharmacology and Experimental Therapeutics December 1993, 267 (3) 1582-1590;

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