Journal of Pharmacology and Experimental Therapeutics: 266 (3)

September 01, 1993; Volume 266,Issue 3

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Characterization of the contractile effects of human recombinant nonpancreatic secretory phospholipase A2 (PLA2) and other PLA2s on guinea pig lung pleural strips.
D W Snyder, C D Sommers, J L Bobbitt and E D Mihelich

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1147-1155;
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U73122 affects the equilibria between the phosphoinositides as well as phospholipase C activity in unstimulated and thrombin-stimulated human and rabbit platelets.
J D Vickers

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1156-1163;
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The minocycline-induced thyroid pigment and several synthetic models: identification and characterization by electron paramagnetic resonance spectroscopy.
W S Enochs, M J Nilges and H M Swartz

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1164-1176;
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Pharmacological profile of the dopamine partial agonist, (+/-)-PD 128483 and its enantiomers.
L T Meltzer, B W Caprathe, C L Christoffersen, A E Corbin, J C Jaen, F W Ninteman, T A Pugsley, K A Serpa, Y H Shih and S Z Whetzel

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1177-1189;
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Release of endogenous acetylcholine from a vascularly perfused rat stomach in vitro; inhibition by M3 muscarinic autoreceptors and alpha-2 adrenoceptors.
K Yokotani, Y Okuma, K Nakamura and Y Osumi

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1190-1195;
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Role of polymorphic debrisoquin 4-hydroxylase activity in the stereoselective disposition of mexiletine in humans.
Z Abolfathi, C Fiset, M Gilbert, K Moerike, P M Bélanger and J Turgeon

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1196-1201;
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A dual-component positive inotropic effect of endothelin-1 in guinea pig left atria: a role of protein kinase C.
Y Hattori, H Nakaya, J Nishihira and M Kanno

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1202-1212;
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RP 59037 and RP 60503: anxiolytic cyclopyrrolone derivatives with low sedative potential. interaction with the gamma-aminobutyric acidA/benzodiazepine receptor complex and behavioral effects in the rodent.
A Doble, T Canton, S Dreisler, O Piot, A Boireau, J M Stutzmann, M C Bardone, J Rataud, M Roux and G Roussel

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1213-1226;
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Potentiation of gamma-aminobutyric acid type A receptor-mediated synaptic currents by pentobarbital and diazepam in immature hippocampal CA1 neurons.
L Zhang, J L Weiner and P L Carlen

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1227-1235;
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Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies.
D P Devine, P Leone, D Pocock and R A Wise

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1236-1246;
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Improvement of ischemia/reperfusion-induced contractile dysfunction of perfused hearts by class Ic antiarrhythmic agents.
J X Liu, K Tanonaka, Y Ohtsuka, Y Sakai and S Takeo

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1247-1254;
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The mycotoxin, deoxynivalenol, delays gastric emptying through serotonin-3 receptors in rodents.
J Fioramonti, C Dupuy, J Dupuy and L Bueno

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1255-1260;
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Isobolographic superadditivity between delta and mu opioid agonists in the rat depends on the ratio of compounds, the mu agonist and the analgesic assay used.
J U Adams, R J Tallarida, E B Geller and M W Adler

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1261-1267;
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Downregulation of nicotinic receptor function after chronic nicotine infusion.
M J Marks, S R Grady and A C Collins

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1268-1276;
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Microdialysis study of the effects of sedative drugs on extracellular histamine in the striatum of freely moving rats.
T Chikai, R Oishi and K Saeki

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1277-1281;
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Requirement for iron for the production of hydroxyl radicals by rat liver quinone reductase.
E Dicker and A I Cederbaum

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1282-1290;
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Characterization of bradykinin receptors in guinea pig gall bladder.
R C Falcone, S J Hubbs, J D Vanderloo, J C Prosser, J Little, B Gomes, D Aharony and R D Krell

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1291-1299;
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Induction of tolerance to and physical dependence on pentobarbital continuous intracerebroventricular administration.
T Kimura, T Miyaoka, P A Saunders, M L Baker, A S Hume, I Yamamoto and I K Ho

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1300-1305;
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Gastric mucosal endogenous prostanoids are involved in the cellular regulation of acid secretion from isolated parietal cells.
A Choquet, R Magous and J P Bali

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1306-1311;
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The role of biotransformation in anthracycline-induced cardiotoxicity in mice.
J de Jong, P R Schoofs, A M Snabilié, A Bast and W J van der Vijgh

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1312-1320;
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Neuropeptide Y modulates the vascular response to periarterial nerve stimulation primarily by a postjunctional action in the isolated perfused rat kidney.
W F Oellerich and K U Malik

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1321-1329;
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Involvement of calcium and L-type channels in nicotine-induced antinociception.
M I Damaj, S P Welch and B R Martin

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1330-1338;
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SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae.
D C Yang, B Goldstin, A E Moormann, D L Flynn and G W Gullikson

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1339-1347;
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Antifibrillatory effects of ibutilide in the rabbit isolated heart: mediation via ATP-dependent potassium channels.
G S Friedrichs, L Chi, S C Black, P J Manley, J Y Oh and B R Lucchesi

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1348-1354;
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Prostaglandin E2-induced thermal hyperalgesia and its reversal by morphine in the warm-water tail-withdrawal procedure in rhesus monkeys.
S S Negus, E R Butelman, Y Al and J H Woods

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1355-1363;
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Alcohol and cocaine interactions in humans.
M Farré, R de la Torre, M Llorente, X Lamas, B Ugena, J Segura and J Camí

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1364-1373;
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Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors.
C A Stockmeier, J J DiCarlo, Y Zhang, P Thompson and H Y Meltzer

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1374-1384;
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Chronic kappa opioid receptor antagonism produces supersensitivity to U-50,488H at the hypothalamo-pituitary-adrenocortical (HPA) axis level.
C Alcaraz, M V Milanés and M L Vargas

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1385-1389;
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A comparison of the effects of chronic nicotine infusion on tolerance to nicotine and cross-tolerance to ethanol in long- and short-sleep mice.
A C Collins, E Romm, S Selvaag, S Turner and M J Marks

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1390-1397;
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A comparison of the development of tolerance to ethanol and cross-tolerance to nicotine after chronic ethanol treatment in long- and short-sleep mice.
C M de Fiebre and A C Collins

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1398-1406;
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The role of endogenous opioids as mediators of the hypothermic effects of intrathecally administered calcium and calcitonin gene-related peptide in mice.
F L Smith, S P Welch, D S Dombrowski and W L Dewey

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1407-1415;
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Neurogenic and non-neurogenic relaxations caused by nicotine in isolated dog superficial temporal artery.
T Okamura, M Enokibori and N Toda

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1416-1421;
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The cardioprotective, vasorelaxant and electrophysiological profile of the large conductance calcium-activated potassium channel opener NS-004.
C A Sargent, G J Grover, M J Antonaccio and J R McCullough

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1422-1429;
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Spinal involvement of both dynorphin A and Met-enkephalin in the antinociception induced by intracerebroventricularly administered bremazocine but not morphine in the mouse.
L F Tseng and K A Collins

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1430-1438;
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Disposition of a monoclonal anti-phencyclidine Fab fragment of immunoglobulin G in rats.
M B McClurkan, J L Valentine, L Arnold and S M Owens

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1439-1445;
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Thermoregulatory effects of beta adrenoceptors: effects of selective agonists and the interaction of antagonists with isoproterenol and BRL-35135 in the cold.
H J Carlisle and M J Stock

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1446-1453;
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Antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic KKAy and C57BL6Job/ob mice and increases glucose disappearance in rhesus monkeys.
M D Meglasson, J M Wilson, J H Yu, D D Robinson, B M Wyse and C J de Souza

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1454-1462;
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Thermodynamic analysis of agonist and antagonist binding to membrane-bound and solubilized A1 adenosine receptors.
V Casadó, G Allende, J Mallol, R Franco, C Lluis and E I Canela

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1463-1474;
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Extracellular calcium and intrinsic tone in the human umbilical artery.
M E Wylam, R W Samsel, P T Schumacker and J G Umans

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1475-1481;
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Potassium channel-mediated relaxation to acetylcholine in rabbit arteries.
C L Cowan, J J Palacino, S Najibi and R A Cohen

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1482-1489;
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Gamma-aminobutyric acidB, but not gamma-aminobutyric acidA receptor activation, inhibits electrically evoked substance P-like immunoreactivity release from the rat spinal cord in vitro.
M Malcangio and N G Bowery

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1490-1496;
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Vascular smooth muscle contains a depletable store of a vasodilator which is light-activated and restored by donors of nitric oxide.
C M Venturini, R M Palmer and S Moncada

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1497-1500;
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Antithrombotic effects of MK-0852, a platelet fibrinogen receptor antagonist, in canine models of thrombosis.
D R Ramjit, J J Lynch, G R Sitko, M J Mellott, M A Holahan, I I Stabilito, M T Stranieri, G Zhang, R J Lynch and P D Manno

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1501-1511;
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Stimulation by nitric oxide synthase inhibitors of gastric and duodenal HCO3- secretion in rats.
K Takeuchi, T Ohuchi, H Miyake and S Okabe

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1512-1519;
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Tonic tone in arteries exposed continuously to angiotensin II in vitro.
P M Schiffers, H A van der Heijden, G E Fazzi, H A Boudier and J G De Mey

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1520-1527;
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Coronary vascular injury following transient coronary artery occlusion: prevention by pretreatment with deferoxamine, dimethylthiourea and N-2-mercaptoproprionyl glycine.
E Patterson

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1528-1535;
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Age-related changes in melatonin modulation of sympathetic neurotransmission.
R C Carneiro, E P Pereira, J Cipolla-Neto and R P Markus

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1536-1540;
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[3H]1-(cyclopropylmethyl)-4-(2-(4-fluorophenyl)-2-oxoethyl) piperidine HBr (DuP 734). A selective ligand for sigma receptors in mouse brain in vivo.
M Watanabe, D Rominger, S D Hurt, E B De Souza and S W Tam

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1541-1548;
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Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam.
R Fern, B R Ransom, P K Stys and S G Waxman

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1549-1555;
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Renal effects of rilmenidine in anesthetized rats: importance of renal nerves.
R L Kline and D F Cechetto

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1556-1562;
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Caffeine treatment and withdrawal in mice: relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding.
G B Kaplan, D J Greenblatt, M A Kent and M M Cotreau-Bibbo

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1563-1572;
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Selective antagonism of native and cloned kainate and NMDA receptors by polyamine-containing toxins.
P T Brackley, D R Bell, S K Choi, K Nakanishi and P N Usherwood

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1573-1580;
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Effect of a novel diuretic, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(IH)-quinolinone-4-oxime-o- sulfonic acid, potassium salt (M17055) on Na+ and K+ transport in the distal nephron segments.
K Yasoshima, F Yamasaki, T Shinkawa, K Yoshitomi and M Imai

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1581-1588;
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Effects of amiloride and a novel diuretic, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone-4-oxime-o-su lfonic acid, potassium salt (M17055), on calcium transport in the rabbit connecting tubule.
F Yamasaki, K Yoshitomi, T Shinkawa and M Imai

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1589-1593;
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A pharmacological investigation of the contribution of muscarinic receptor-linked potassium channels to the reversal by carbachol of positive inotropic responses of rabbit left atrium to cyclic AMP-generating agents.
A Ray and K M MacLeod

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1594-1601;
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Chronic naloxone treatment induces supersensitivity to a mu but not to a kappa agonist at the hypothalamus-pituitary-adrenocortical axis level.
C Alcaraz, M L Vargas, T Fuente and M V Milanés

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1602-1606;
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Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice.
J Liu, Y Liu, C Madhu and C D Klaassen

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1607-1613;
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Digoxin-cyclosporin A interaction: modulation of the multidrug transporter P-glycoprotein in the kidney.
N Okamura, M Hirai, Y Tanigawara, K Tanaka, M Yasuhara, K Ueda, T Komano and R Hori

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1614-1619;
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Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney.
R Hori, N Okamura, T Aiba and Y Tanigawara

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1620-1625;
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Methylmercury increases intracellular concentrations of Ca++ and heavy metals in NG108-15 cells.
M F Hare, K M McGinnis and W D Atchison

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1626-1635;
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Retinoic acid metabolites exhibit biological activity in human keratinocytes, mouse melanoma cells and hairless mouse skin in vivo.
N J Reynolds, G J Fisher, C E Griffiths, A Tavakkol, H S Talwar, P E Rowse, T A Hamilton and J J Voorhees

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1636-1642;
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Preclinical safety studies of glucose oxidase.
M Samoszuk, D Ehrlich and E Ramzi

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1643-1648;
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Assessment of an in vitro blood-brain barrier model using several [Met5]enkephalin opioid analogs.
S J Weber, T J Abbruscato, E A Brownson, A W Lipkowski, R Polt, A Misicka, R C Haaseth, H Bartosz, V J Hruby and T P Davis

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1649-1655;
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Further evidence of the tumor-suppressive effects of cadmium in the B6C3F1 mouse liver and lung: late stage vulnerability of tumors to cadmium and the role of metallothionein.
M P Waalkes, B A Diwan, C M Weghorst, J M Ward, J M Rice, M G Cherian and R A Goyer

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1656-1663;
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TCV-116, a novel angiotensin II receptor antagonist, prevents intimal thickening and impairment of vascular function after carotid injury in rats.
M Kawamura, Z Terashita, H Okuda, Y Imura, A Shino, M Nakao and K Nishikawa

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1664-1669;
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Cyclocreatine inhibits neutrophil accumulation in the myocardium of a canine model of coronary artery occlusion and reperfusion.
S A Elgebaly, M E Allam, S Houser, F Hashmi, F Forouhar and D Miano

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1670-1677;
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The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein.
D M Lawrence and J M Bidlack

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1678-1683;
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Chronic denervation of rat jejunum results in cholinergic supersensitivity due to reduction of cholinesterase activity.
M A Osinski and P Bass

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1684-1690;
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Demonstration of novel anti-arthritic and anti-inflammatory effects of diphosphonates.
C J Dunn, L A Galinet, H Wu, R A Nugent, S T Schlachter, N D Staite, D G Aspar, G A Elliott, N A Essani and N A Rohloff

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1691-1698;
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Inhibitory effect of 5,6,7,8-tetrahydroneopterin on adriamycin-induced cardiotoxicity.
S Kojima, T Icho, M Hayashi, Y Kajiwara, K Kitabatake and K Kubota

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1699-1704;
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Ethanol decreases glutamatergic synaptic transmission in rat nucleus accumbens in vitro: naloxone reversal.
Z Nie, X Yuan, S G Madamba and G R Siggins

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1705-1712;
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Temporary focal cerebral ischemia in spontaneously hypertensive rats: the effect of ibuprofen on infarct volume.
D J Cole, P M Patel, L Reynolds, J C Drummond and S Marcantonio

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1713-1717;
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Central angiotensin IV binding sites: distribution and specificity in guinea pig brain.
A V Miller-Wing, J M Hanesworth, M F Sardinia, K L Hall, J W Wright, R C Speth, K L Grove and J W Harding

Journal of Pharmacology and Experimental Therapeutics September 1993, 266 (3) 1718-1726;

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