Journal of Pharmacology and Experimental Therapeutics: 265 (2)

May 01, 1993; Volume 265,Issue 2

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A prodrug of a 2,6-disubstituted 4-(2-arylethenyl)phenol is a selective and orally active 5-lipoxygenase inhibitor.
P R Farina, A G Graham, C A Homon, E S Lazer, S E Hattox, P S Riska, R H Gundel and C D Wegner

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 483-489;
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Calcitonin gene-related peptide relaxes porcine coronary arteries via cyclic AMP-dependent mechanisms, but not activation of ATP-sensitive potassium channels.
M Kageyama, T Yanagisawa and N Taira

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 490-497;
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Dopamine D1, D2 and serotonin2 receptor occupation by typical and atypical antipsychotic drugs in vivo.
S Matsubara, R Matsubara, I Kusumi, T Koyama and I Yamashita

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 498-508;
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Identification of octopaminergic agonists with selectivity for octopamine receptor subtypes.
J A Nathanson

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 509-515;
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5-Methyl-4H-3,1-benzoxazin-4-one derivatives: specific inhibitors of human leukocyte elastase.
Y Uejima, M Kokubo, J Oshida, H Kawabata, Y Kato and K Fujii

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 516-523;
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Effect of calcium agonists, BAY K 8644 and CGP 28392, on guinea pig airway smooth muscle function during development.
B E Pichoff, C F Uyehara and K T Nakamura

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 524-528;
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Selective block of transient Ca channel current in mouse neuroblastoma cells by U-88779E.
H K Im, W B Im and K Tsuzuki

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 529-535;
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A cholinergic interaction in alpha 2 adrenoceptor-mediated antinociception in sheep.
D J Detweiler, J C Eisenach, C Tong and C Jackson

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 536-542;
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Correlation of (-)N6-phenylisopropyladenosine blood levels with cardiac responses in the anesthetized guinea pig.
D M Dennis, J Shryock and L Belardinelli

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 543-550;
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Cross-tolerance between mu opioid and alpha-2 adrenergic receptors, but not between mu and delta opioid receptors in the spinal cord of the rat.
E A Kalso, A F Sullivan, H J McQuay, A H Dickenson and B P Roques

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 551-558;
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The ATP-sensitive potassium channel blocker glibenclamide (glyburide) does not abolish preconditioning in isolated ischemic rat hearts.
G J Grover, S Dzwonczyk, P G Sleph and C A Sargent

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 559-564;
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Benzodiazepine receptor ligands are elevated in an animal model of hepatic encephalopathy: relationship between brain concentration and severity of encephalopathy.
C Yurdaydin, Z Q Gu, G Nowak, C Fromm, A G Holt and A S Basile

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 565-571;
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Studies on the neuronal circuits involved in the discriminative stimulus effects of 5-hydroxytryptamine1A receptor agonists in the rat.
R Schreiber and J de Vry

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 572-579;
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Role of neurotensin in the nucleus raphe magnus in opioid-induced antinociception from the periaqueductal gray.
M O Urban and D J Smith

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 580-586;
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Cocaine and its metabolites constrict cerebral arterioles in newborn pigs.
C D Kurth, C Monitto, M L Albuquerque, P Feuer, E Anday and L Shaw

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 587-591;
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Intracranial cocaine self-administration into the medial prefrontal cortex increases dopamine turnover in the nucleus accumbens.
N E Goeders and J E Smith

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 592-600;
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Characterization of angiotensin receptors mediating the neuromodulatory effects of angiotensin in the vas deferens of the rabbit.
S S Hegde and D E Clarke

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 601-608;
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Cardioprotection in ischemic rat hearts with the SH-containing angiotensin-converting enzyme inhibitor zofenopril: possible involvement of the ATP-sensitive potassium channel.
C A Sargent, P G Sleph, S Dzwonczyk, M A Smith, D Normandin, M J Antonaccio and G J Grover

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 609-618;
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Xenopsin, neurotensin, neurotensin(8-13) and N-acetyl-neurotensin(8-13) inhibit vascular leakage in rats after tissue injury.
G C Gao and E T Wei

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 619-625;
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The calcium channel antagonist, pimozide, blocks the cyclic GMP-activated current in rod photoreceptors.
G D Nicol

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 626-632;
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Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalanine-leucine, ICI 174,864 or naloxone in mice.
S P Welch

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 633-640;
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Carbachol-induced sodium current in guinea pig ventricular myocytes is not regulated by guanine nucleotides.
T Shirayama, K Matsumoto and A J Pappano

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 641-648;
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Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
J Auta, E Romeo, A Kozikowski, D Ma, E Costa and A Guidotti

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 649-656;
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Is sympathetic neurotransmission in the rat mesentery modulated by prejunctional beta adrenoceptors?
H M Sadeghi and D C Eikenburg

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 657-663;
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Differential regulation of prostaglandin synthesis by angiotensin peptides in porcine aortic smooth muscle cells: subtypes of angiotensin receptors involved.
N Jaiswal, E A Tallant, R K Jaiswal, D I Diz and C M Ferrario

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 664-673;
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Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide.
C Szabó, J A Mitchell, S S Gross, C Thiemermann and J R Vane

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 674-680;
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Dosing rate-dependent relationship between propranolol plasma concentration and beta-blockade.
H Takahashi, H Ogata, K Kashiwada, M Ohira and K Someya

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 681-689;
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Aging effects on stereoselective pharmacokinetics and pharmacodynamics of verapamil.
J B Schwartz, I F Troconiz, D Verotta, S Liu and H Capili

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 690-698;
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In vitro and in vivo characterization of an A1-selective adenosine agonist, RG14202.
L A Merkel, L M Rivera, D J Colussi, M H Perrone, G J Smits and B F Cox

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 699-706;
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In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol.
S Hjorth and T Sharp

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 707-712;
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Nonadrenergic, noncholinergic inhibitory control of the rat external urethral sphincter: involvement of nitric oxide.
M Parlani, B Conte and S Manzini

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 713-719;
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Cardiac electrophysiologic and antiarrhythmic actions of 3,4-dihydro-1'-[2-(benzofurazan-5-yl) ethyl]-6-methanesulfonamidospiro [(2H)-1-benzopyran-2,4'-piperidin]-4-one HCl (L-691,121), a novel class III agent.
J J Lynch, A A Wallace, L H Van der Gaag, E P Baskin, C M Bear, J R Gehret, T Kothstein, R F Stupienski, S D Appleby and M C Sanguinetti

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 720-730;
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Gastrointestinal and hepatic first-pass elimination of 2',3'-dideoxyinosine in rats.
S L Bramer, J L Au and M G Wientjes

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 731-738;
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Tertatolol, a new beta-blocker, is a serotonin (5-hydroxytryptamine1A) receptor antagonist in rat brain.
S Prisco, A Cagnotto, D Talone, A De Blasi, T Mennini and E Esposito

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 739-744;
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Comparative study of 2-(4-ethyl-1-piperazinyl)-4-(fluorophenyl)-5,6,7,8,9, 10-hexahydrocycloocta[b]pyridine (AD-5423) and haloperidol for their pharmacological activities related to antipsychotic efficacy and/or adverse side-effects.
Y Noda, S Kurumiya, Y Miura and M Oka

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 745-751;
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Pharmacological characterization of FK1052, a dihydropyridoindole derivative, as a new serotonin 3 and 4 dual receptor antagonist.
Y Nagakura, M Kadowaki, K Tokoro, M Tomoi, J Mori and M Kohsaka

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 752-758;
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Effect of in vivo microdialysis of 1,2,3,4-tetrahydro-9-aminoacridine (THA) on the extracellular concentration of acetylcholine in the striatum of anesthetized rats.
W B Xiao, A Nordberg and X Zhang

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 759-764;
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gamma-Aminobutyric acid (GABA) autoreceptors in rat cerebral cortex and spinal cord represent pharmacologically distinct subtypes of the GABAB receptor.
G Bonanno and M Raiteri

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 765-770;
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Trichloroethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in nodose ganglion neurons from the adult rat.
D M Lovinger and Q Zhou

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 771-776;
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Adrenergic, serotonergic and cholinergic components of nicotinic antinociception in rats.
E T Iwamoto and L Marion

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 777-789;
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Proliferation of nontransformed cells is inhibited by adenosine metabolite of but not by parental 8-Cl-cyclic AMP.
Z Han, D Chatterjee and J H Wyche

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 790-794;
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Arsenic in the sera of gallium arsenide-exposed mice inhibits bacterial growth and increases host resistance.
L A Burns, J A McCay, R Brown and A E Munson

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 795-800;
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A bradycardic agent, UL-FS 49, increases atrial force and decreases ventricular force in isolated, perfused heart preparations of dogs.
Y Furukawa, S Takayama, S Sawaki, Y Inoue and S Chiba

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 801-806;
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Functional characterization of alpha adrenoceptors on rabbit intrarenal arteries in vitro.
M P Owen

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 807-812;
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Short-term effects of 2,4,5-trihydroxyamphetamine, 2,4,5-trihydroxymethamphetamine and 3,4-dihydroxymethamphetamine on central tryptophan hydroxylase activity.
I Elayan, J W Gibb, G R Hanson, H K Lim, R L Foltz and M Johnson

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 813-818;
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Effect of MCI-154, a cardiotonic agent, on regional contractile function and myocardial oxygen consumption in the presence and absence of coronary artery stenosis in dogs.
Y Abe, Y Kitada and A Narimatsu

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 819-825;
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Pharmacological characterization of SR 47436, a new nonpeptide AT1 subtype angiotensin II receptor antagonist.
C Cazaubon, J Gougat, F Bousquet, P Guiraudou, R Gayraud, C Lacour, A Roccon, G Galindo, G Barthelemy and B Gautret

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 826-834;
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N-acetyl beta-endorphin-(1-31) and substance P regulate the supraspinal antinociception mediated by mu opioid and alpha-2 adrenoceptors but not by delta opioid receptors in the mouse.
P Sánchez-Blázquez and J Garzón

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 835-843;
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Effects of MK-801 on the micturition reflex in the rat--possible sites of action.
M Yoshiyama, J R Roppolo and W C de Groat

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 844-850;
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Increase in extracellular acetylcholine level by sigma ligands in rat frontal cortex.
K Matsuno, K Matsunaga, T Senda and S Mita

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 851-859;
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The action of amlodipine on human subcutaneous resistance arteries studied in vitro.
R S Garcha, P S Sever and A D Hughes

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 860-865;
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NPC 16377, a potent and selective sigma-ligand. I. Receptor binding, neurochemical and neuroendocrine profile.
E W Karbon, M E Abreu, R H Erickson, C Kaiser, K J Natalie, D B Clissold, S Borosky, M Bailey, L A Martin and M J Pontecorvo

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 866-875;
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NPC 16377, a potent and selective sigma-ligand. II. Behavioral and neuroprotective profile.
D B Clissold, M J Pontecorvo, B E Jones, M E Abreu, E W Karbon, R H Erickson, K J Natalie, S Borosky, T Hartman and R S Mansbach

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 876-886;
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Similarities and differences in the postjunctional role for neuropeptide Y in sympathetic vasomotor control of large vs. small arteries of rabbit renal and ear vasculature.
M P Owen

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 887-895;
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Agonist and antagonist profiles of [D-Ala2,Glu4]deltorphin and its [Cys4]- and [Ser4]-substituted derivatives: further evidence of opioid delta receptor multiplicity.
P J Horan, K D Wild, A Misicka, A Lipkowski, R C Haaseth, V J Hruby, S J Weber, T P Davis, H I Yamamura and F Porreca

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 896-902;
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Neuropeptide Y and pancreatic polypeptide reduce calcium currents in acutely dissociated neurons from adult rat superior cervical ganglia.
S Foucart, D Bleakman, V P Bindokas and R J Miller

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 903-909;
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Are chimeric kainate/N-methyl-D-aspartate receptors expressed in Xenopus oocytes from mammalian and amphibian RNA?
P T Brackley and P N Usherwood

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 910-919;
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Atrial natriuretic peptide inhibits the purinergic and not the adrenergic component of electrically induced contractile responses in guinea pig vas deferens.
V N Mutafova-Yambolieva, K M Venkova and L S Lasova

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 920-926;
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Activation of nociceptive reflexes by peripheral kainate receptors.
B Ault and L M Hildebrand

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 927-932;
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Unique natriuretic properties of the ATP-sensitive K(+)-channel blocker glyburide in conscious rats.
M A Clark, S J Humphrey, M P Smith and J H Ludens

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 933-937;
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Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice.
M I Walton and P Workman

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 938-947;
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Effect of orogastric nicotine on rat gastric mucosal gel thickness, surface cell viability and intracellular pH.
J D Kaunitz, Y Nishizaki, K Kaneko and P H Guth

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 948-954;
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In vitro effects of long-chain acylcarnitines on the permeability, transepithelial electrical resistance and morphology of rat colonic mucosa.
E L Lecluyse, S C Sutton and J A Fix

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 955-962;
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Electrophysiological effects of putative autoreceptor-selective dopamine agonists on A10 dopamine neurons.
J M Ackerman, P A Johansen, D Clark and F J White

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 963-970;
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Effects of adenosine agonists on ventilation during hypercapnia, hypoxia and hyperoxia in rhesus monkeys.
L L Howell

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 971-978;
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Irreversible suppression of growth hormone-dependent cytochrome P450 2C11 in adult rats neonatally treated with monosodium glutamate.
B H Shapiro, N A Pampori, P A Ram and D J Waxman

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 979-984;
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Characterization of the gamma-aminobutyric acidA receptor-channel complex composed of alpha 1 beta 2 and alpha 1 beta 3 subunits from rat brain.
A Y Valeyev, J L Barker, R A Cruciani, G D Lange, V V Smallwood and L C Mahan

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 985-991;
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Relationship of thermal and chemical tolerance to transepithelial transport by cultured flounder renal epithelium.
J L Renfro, M A Brown, S L Parker and L E Hightower

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 992-1000;
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Evidence for involvement of brain dopamine and other mechanisms in the behavioral action of the N-methyl-D-aspartic acid antagonist MK-801 in control and 6-hydroxydopamine-lesioned rats.
H E Criswell, K B Johnson, R A Mueller and G R Breese

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 1001-1010;
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2,3-Butanedione monoxime (BDM) inhibition of delayed rectifier DRK1 (Kv2.1) potassium channels expressed in Xenopus oocytes.
A N Lopatin and C G Nichols

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 1011-1016;
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Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons.
Y Tamura, Y Sato, T Yokota, A Akaike, M Sasa and S Takaori

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 1017-1025;
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Effects of a K+ATP channel opener, lemakalim, on systemic, coronary and regional vascular dynamics in conscious dogs: comparison with nifedipine, adenosine, nitroglycerin and acetylcholine.
Y T Shen and S F Vatner

Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 1026-1037;

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