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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

May 01, 1993; Volume 265,Issue 2
  • You have access
    A prodrug of a 2,6-disubstituted 4-(2-arylethenyl)phenol is a selective and orally active 5-lipoxygenase inhibitor.
    P R Farina, A G Graham, C A Homon, E S Lazer, S E Hattox, P S Riska, R H Gundel and C D Wegner
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 483-489;
  • You have access
    Calcitonin gene-related peptide relaxes porcine coronary arteries via cyclic AMP-dependent mechanisms, but not activation of ATP-sensitive potassium channels.
    M Kageyama, T Yanagisawa and N Taira
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 490-497;
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    Dopamine D1, D2 and serotonin2 receptor occupation by typical and atypical antipsychotic drugs in vivo.
    S Matsubara, R Matsubara, I Kusumi, T Koyama and I Yamashita
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 498-508;
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    Identification of octopaminergic agonists with selectivity for octopamine receptor subtypes.
    J A Nathanson
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 509-515;
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    5-Methyl-4H-3,1-benzoxazin-4-one derivatives: specific inhibitors of human leukocyte elastase.
    Y Uejima, M Kokubo, J Oshida, H Kawabata, Y Kato and K Fujii
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 516-523;
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    Effect of calcium agonists, BAY K 8644 and CGP 28392, on guinea pig airway smooth muscle function during development.
    B E Pichoff, C F Uyehara and K T Nakamura
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 524-528;
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    Selective block of transient Ca channel current in mouse neuroblastoma cells by U-88779E.
    H K Im, W B Im and K Tsuzuki
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 529-535;
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    A cholinergic interaction in alpha 2 adrenoceptor-mediated antinociception in sheep.
    D J Detweiler, J C Eisenach, C Tong and C Jackson
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 536-542;
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    Correlation of (-)N6-phenylisopropyladenosine blood levels with cardiac responses in the anesthetized guinea pig.
    D M Dennis, J Shryock and L Belardinelli
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 543-550;
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    Cross-tolerance between mu opioid and alpha-2 adrenergic receptors, but not between mu and delta opioid receptors in the spinal cord of the rat.
    E A Kalso, A F Sullivan, H J McQuay, A H Dickenson and B P Roques
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 551-558;
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    The ATP-sensitive potassium channel blocker glibenclamide (glyburide) does not abolish preconditioning in isolated ischemic rat hearts.
    G J Grover, S Dzwonczyk, P G Sleph and C A Sargent
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 559-564;
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    Benzodiazepine receptor ligands are elevated in an animal model of hepatic encephalopathy: relationship between brain concentration and severity of encephalopathy.
    C Yurdaydin, Z Q Gu, G Nowak, C Fromm, A G Holt and A S Basile
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 565-571;
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    Studies on the neuronal circuits involved in the discriminative stimulus effects of 5-hydroxytryptamine1A receptor agonists in the rat.
    R Schreiber and J de Vry
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 572-579;
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    Role of neurotensin in the nucleus raphe magnus in opioid-induced antinociception from the periaqueductal gray.
    M O Urban and D J Smith
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 580-586;
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    Cocaine and its metabolites constrict cerebral arterioles in newborn pigs.
    C D Kurth, C Monitto, M L Albuquerque, P Feuer, E Anday and L Shaw
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 587-591;
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    Intracranial cocaine self-administration into the medial prefrontal cortex increases dopamine turnover in the nucleus accumbens.
    N E Goeders and J E Smith
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 592-600;
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    Characterization of angiotensin receptors mediating the neuromodulatory effects of angiotensin in the vas deferens of the rabbit.
    S S Hegde and D E Clarke
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 601-608;
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    Cardioprotection in ischemic rat hearts with the SH-containing angiotensin-converting enzyme inhibitor zofenopril: possible involvement of the ATP-sensitive potassium channel.
    C A Sargent, P G Sleph, S Dzwonczyk, M A Smith, D Normandin, M J Antonaccio and G J Grover
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 609-618;
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    Xenopsin, neurotensin, neurotensin(8-13) and N-acetyl-neurotensin(8-13) inhibit vascular leakage in rats after tissue injury.
    G C Gao and E T Wei
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 619-625;
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    The calcium channel antagonist, pimozide, blocks the cyclic GMP-activated current in rod photoreceptors.
    G D Nicol
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 626-632;
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    Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalanine-leucine, ICI 174,864 or naloxone in mice.
    S P Welch
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 633-640;
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    Carbachol-induced sodium current in guinea pig ventricular myocytes is not regulated by guanine nucleotides.
    T Shirayama, K Matsumoto and A J Pappano
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 641-648;
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    Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
    J Auta, E Romeo, A Kozikowski, D Ma, E Costa and A Guidotti
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 649-656;
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    Is sympathetic neurotransmission in the rat mesentery modulated by prejunctional beta adrenoceptors?
    H M Sadeghi and D C Eikenburg
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 657-663;
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    Differential regulation of prostaglandin synthesis by angiotensin peptides in porcine aortic smooth muscle cells: subtypes of angiotensin receptors involved.
    N Jaiswal, E A Tallant, R K Jaiswal, D I Diz and C M Ferrario
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 664-673;
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    Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide.
    C Szabó, J A Mitchell, S S Gross, C Thiemermann and J R Vane
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 674-680;
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    Dosing rate-dependent relationship between propranolol plasma concentration and beta-blockade.
    H Takahashi, H Ogata, K Kashiwada, M Ohira and K Someya
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 681-689;
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    Aging effects on stereoselective pharmacokinetics and pharmacodynamics of verapamil.
    J B Schwartz, I F Troconiz, D Verotta, S Liu and H Capili
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 690-698;
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    In vitro and in vivo characterization of an A1-selective adenosine agonist, RG14202.
    L A Merkel, L M Rivera, D J Colussi, M H Perrone, G J Smits and B F Cox
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 699-706;
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    In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol.
    S Hjorth and T Sharp
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 707-712;
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    Nonadrenergic, noncholinergic inhibitory control of the rat external urethral sphincter: involvement of nitric oxide.
    M Parlani, B Conte and S Manzini
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 713-719;
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    Cardiac electrophysiologic and antiarrhythmic actions of 3,4-dihydro-1'-[2-(benzofurazan-5-yl) ethyl]-6-methanesulfonamidospiro [(2H)-1-benzopyran-2,4'-piperidin]-4-one HCl (L-691,121), a novel class III agent.
    J J Lynch, A A Wallace, L H Van der Gaag, E P Baskin, C M Bear, J R Gehret, T Kothstein, R F Stupienski, S D Appleby and M C Sanguinetti
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 720-730;
  • You have access
    Gastrointestinal and hepatic first-pass elimination of 2',3'-dideoxyinosine in rats.
    S L Bramer, J L Au and M G Wientjes
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 731-738;
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    Tertatolol, a new beta-blocker, is a serotonin (5-hydroxytryptamine1A) receptor antagonist in rat brain.
    S Prisco, A Cagnotto, D Talone, A De Blasi, T Mennini and E Esposito
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 739-744;
  • You have access
    Comparative study of 2-(4-ethyl-1-piperazinyl)-4-(fluorophenyl)-5,6,7,8,9, 10-hexahydrocycloocta[b]pyridine (AD-5423) and haloperidol for their pharmacological activities related to antipsychotic efficacy and/or adverse side-effects.
    Y Noda, S Kurumiya, Y Miura and M Oka
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 745-751;
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    Pharmacological characterization of FK1052, a dihydropyridoindole derivative, as a new serotonin 3 and 4 dual receptor antagonist.
    Y Nagakura, M Kadowaki, K Tokoro, M Tomoi, J Mori and M Kohsaka
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 752-758;
  • You have access
    Effect of in vivo microdialysis of 1,2,3,4-tetrahydro-9-aminoacridine (THA) on the extracellular concentration of acetylcholine in the striatum of anesthetized rats.
    W B Xiao, A Nordberg and X Zhang
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 759-764;
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    gamma-Aminobutyric acid (GABA) autoreceptors in rat cerebral cortex and spinal cord represent pharmacologically distinct subtypes of the GABAB receptor.
    G Bonanno and M Raiteri
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 765-770;
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    Trichloroethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in nodose ganglion neurons from the adult rat.
    D M Lovinger and Q Zhou
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 771-776;
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    Adrenergic, serotonergic and cholinergic components of nicotinic antinociception in rats.
    E T Iwamoto and L Marion
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 777-789;
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    Proliferation of nontransformed cells is inhibited by adenosine metabolite of but not by parental 8-Cl-cyclic AMP.
    Z Han, D Chatterjee and J H Wyche
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 790-794;
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    Arsenic in the sera of gallium arsenide-exposed mice inhibits bacterial growth and increases host resistance.
    L A Burns, J A McCay, R Brown and A E Munson
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 795-800;
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    A bradycardic agent, UL-FS 49, increases atrial force and decreases ventricular force in isolated, perfused heart preparations of dogs.
    Y Furukawa, S Takayama, S Sawaki, Y Inoue and S Chiba
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 801-806;
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    Functional characterization of alpha adrenoceptors on rabbit intrarenal arteries in vitro.
    M P Owen
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 807-812;
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    Short-term effects of 2,4,5-trihydroxyamphetamine, 2,4,5-trihydroxymethamphetamine and 3,4-dihydroxymethamphetamine on central tryptophan hydroxylase activity.
    I Elayan, J W Gibb, G R Hanson, H K Lim, R L Foltz and M Johnson
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 813-818;
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    Effect of MCI-154, a cardiotonic agent, on regional contractile function and myocardial oxygen consumption in the presence and absence of coronary artery stenosis in dogs.
    Y Abe, Y Kitada and A Narimatsu
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 819-825;
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    Pharmacological characterization of SR 47436, a new nonpeptide AT1 subtype angiotensin II receptor antagonist.
    C Cazaubon, J Gougat, F Bousquet, P Guiraudou, R Gayraud, C Lacour, A Roccon, G Galindo, G Barthelemy and B Gautret
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 826-834;
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    N-acetyl beta-endorphin-(1-31) and substance P regulate the supraspinal antinociception mediated by mu opioid and alpha-2 adrenoceptors but not by delta opioid receptors in the mouse.
    P Sánchez-Blázquez and J Garzón
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 835-843;
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    Effects of MK-801 on the micturition reflex in the rat--possible sites of action.
    M Yoshiyama, J R Roppolo and W C de Groat
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 844-850;
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    Increase in extracellular acetylcholine level by sigma ligands in rat frontal cortex.
    K Matsuno, K Matsunaga, T Senda and S Mita
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 851-859;
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    The action of amlodipine on human subcutaneous resistance arteries studied in vitro.
    R S Garcha, P S Sever and A D Hughes
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 860-865;
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    NPC 16377, a potent and selective sigma-ligand. I. Receptor binding, neurochemical and neuroendocrine profile.
    E W Karbon, M E Abreu, R H Erickson, C Kaiser, K J Natalie, D B Clissold, S Borosky, M Bailey, L A Martin and M J Pontecorvo
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 866-875;
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    NPC 16377, a potent and selective sigma-ligand. II. Behavioral and neuroprotective profile.
    D B Clissold, M J Pontecorvo, B E Jones, M E Abreu, E W Karbon, R H Erickson, K J Natalie, S Borosky, T Hartman and R S Mansbach
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 876-886;
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    Similarities and differences in the postjunctional role for neuropeptide Y in sympathetic vasomotor control of large vs. small arteries of rabbit renal and ear vasculature.
    M P Owen
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 887-895;
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    Agonist and antagonist profiles of [D-Ala2,Glu4]deltorphin and its [Cys4]- and [Ser4]-substituted derivatives: further evidence of opioid delta receptor multiplicity.
    P J Horan, K D Wild, A Misicka, A Lipkowski, R C Haaseth, V J Hruby, S J Weber, T P Davis, H I Yamamura and F Porreca
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 896-902;
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    Neuropeptide Y and pancreatic polypeptide reduce calcium currents in acutely dissociated neurons from adult rat superior cervical ganglia.
    S Foucart, D Bleakman, V P Bindokas and R J Miller
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 903-909;
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    Are chimeric kainate/N-methyl-D-aspartate receptors expressed in Xenopus oocytes from mammalian and amphibian RNA?
    P T Brackley and P N Usherwood
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 910-919;
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    Atrial natriuretic peptide inhibits the purinergic and not the adrenergic component of electrically induced contractile responses in guinea pig vas deferens.
    V N Mutafova-Yambolieva, K M Venkova and L S Lasova
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 920-926;
  • You have access
    Activation of nociceptive reflexes by peripheral kainate receptors.
    B Ault and L M Hildebrand
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 927-932;
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    Unique natriuretic properties of the ATP-sensitive K(+)-channel blocker glyburide in conscious rats.
    M A Clark, S J Humphrey, M P Smith and J H Ludens
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 933-937;
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    Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice.
    M I Walton and P Workman
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 938-947;
  • You have access
    Effect of orogastric nicotine on rat gastric mucosal gel thickness, surface cell viability and intracellular pH.
    J D Kaunitz, Y Nishizaki, K Kaneko and P H Guth
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 948-954;
  • You have access
    In vitro effects of long-chain acylcarnitines on the permeability, transepithelial electrical resistance and morphology of rat colonic mucosa.
    E L Lecluyse, S C Sutton and J A Fix
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 955-962;
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    Electrophysiological effects of putative autoreceptor-selective dopamine agonists on A10 dopamine neurons.
    J M Ackerman, P A Johansen, D Clark and F J White
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 963-970;
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    Effects of adenosine agonists on ventilation during hypercapnia, hypoxia and hyperoxia in rhesus monkeys.
    L L Howell
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 971-978;
  • You have access
    Irreversible suppression of growth hormone-dependent cytochrome P450 2C11 in adult rats neonatally treated with monosodium glutamate.
    B H Shapiro, N A Pampori, P A Ram and D J Waxman
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 979-984;
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    Characterization of the gamma-aminobutyric acidA receptor-channel complex composed of alpha 1 beta 2 and alpha 1 beta 3 subunits from rat brain.
    A Y Valeyev, J L Barker, R A Cruciani, G D Lange, V V Smallwood and L C Mahan
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 985-991;
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    Relationship of thermal and chemical tolerance to transepithelial transport by cultured flounder renal epithelium.
    J L Renfro, M A Brown, S L Parker and L E Hightower
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 992-1000;
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    Evidence for involvement of brain dopamine and other mechanisms in the behavioral action of the N-methyl-D-aspartic acid antagonist MK-801 in control and 6-hydroxydopamine-lesioned rats.
    H E Criswell, K B Johnson, R A Mueller and G R Breese
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 1001-1010;
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    2,3-Butanedione monoxime (BDM) inhibition of delayed rectifier DRK1 (Kv2.1) potassium channels expressed in Xenopus oocytes.
    A N Lopatin and C G Nichols
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 1011-1016;
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    Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons.
    Y Tamura, Y Sato, T Yokota, A Akaike, M Sasa and S Takaori
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 1017-1025;
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    Effects of a K+ATP channel opener, lemakalim, on systemic, coronary and regional vascular dynamics in conscious dogs: comparison with nifedipine, adenosine, nitroglycerin and acetylcholine.
    Y T Shen and S F Vatner
    Journal of Pharmacology and Experimental Therapeutics May 1993, 265 (2) 1026-1037;
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Journal of Pharmacology and Experimental Therapeutics
Vol. 265, Issue 2
1 May 1993
  • Table of Contents
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
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