Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • Log out
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • Log out
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Abstract

Selective effects of cocaine on regional cerebral blood flow in the rat.

E A Stein and S A Fuller
Journal of Pharmacology and Experimental Therapeutics July 1992, 262 (1) 327-334;
E A Stein
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S A Fuller
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Cocaine is a potent central nervous system (CNS) stimulant whose primary mechanism of action is reuptake inhibition of the monoamines at presynaptic transporter sites. Drug-induced stereotypic motor effects may be due to actions within the dorsal striatum and associated structures while reinforcing properties have been attributed to action in the ventral striatal terminal fields of the mesolimbic system. Recent metabolic mapping studies have revealed activation of a limited number of CNS structures. However, because of the pharmacokinetic properties of cocaine, brief duration of action and complex behavioral actions, regional cerebral blood flow (rCBF), a rapid marker of neuronal activity, was used to identify structures involved in different temporal aspects of its pharmacologic profile. Conscious rats were injected i.v. with either 0, 0.1, 0.5, 0.75, 1.0 or 5.0 mg/kg cocaine, 1 min before administration of [14C]iodoantipyrene. A dose-related increase in rCBF was seen in specific terminal fields of the mesolimbic system such as the basolateral and corticomedial nuclei of the amygdala, ventral pallidum, olfactory tubercle and medial prefrontal cortex. Additional structures became activated at successively higher doses, including the nucleus accumbens and ventral pallidum. Biphasic responses were seen in several structures manifest as increased blood flow at 0.1 mg/kg and a decrease or no effect at the mid doses only to increase again after the two highest doses. Thus, rCBF appears to be a sensitive measure of the neuronal effects of cocaine and, as a brief temporal marker of neuronal activity, has identified activation of several novel CNS structures.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 262, Issue 1
1 Jul 1992
  • Table of Contents
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Selective effects of cocaine on regional cerebral blood flow in the rat.
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Abstract

Selective effects of cocaine on regional cerebral blood flow in the rat.

E A Stein and S A Fuller
Journal of Pharmacology and Experimental Therapeutics July 1, 1992, 262 (1) 327-334;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Abstract

Selective effects of cocaine on regional cerebral blood flow in the rat.

E A Stein and S A Fuller
Journal of Pharmacology and Experimental Therapeutics July 1, 1992, 262 (1) 327-334;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics