Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Abstract

Prolactin regulates maternal bile secretory function post partum.

Y Liu, J F Hyde and M Vore
Journal of Pharmacology and Experimental Therapeutics May 1992, 261 (2) 560-566;
Y Liu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J F Hyde
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M Vore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The single-pass isolated perfused rat liver was used to assess bile secretory function in pregnancy and the post partum period and to evaluate the regulatory role of prolactin. Nonpregnant controls, post partum rats (48 hr post partum), pregnant rats (19-20 days of pregnancy) and pregnant rats treated with bromocriptine (3 mg/kg/day, s.c.) from day 20 of pregnancy until 48 hr post partum to block prolactin secretion were examined. In a separate set of experiments, ovariectomized rats were implanted with osmotic minipumps containing solvent alone or solvent plus varying concentrations of ovine prolactin (oPRL). Livers were isolated, [3H]taurocholate (TC) was infused at increasing concentrations and bile flow, bile acid secretory rate and hepatic clearance of TC from the perfusate were determined. Maximal bile flow (microliters/min/g liver) in response to infusion of TC was significantly higher in post partum rats (3.4 +/- 0.3) than in pregnant rats (1.4 +/- 0.3) and bromocriptine-treated post partum rats (1.7 +/- 0.3). The maximal bile acid secretory rate (SRm, nmol/min/g liver) in post partum rats was 276 +/- 19 and was significantly greater than SRm in pregnant (103 +/- 26) and bromocriptine-treated post partum rats (142 +/- 25). Hepatic clearance (ml/min) was significantly greater in post partum rats than in pregnant, control and bromocriptine-treated post partum rats at the highest TC concentration. Infusion of oPRL at doses of 100, 250 and 500 micrograms/day significantly increased maximal bile flow and SRm in a dose-dependent manner; these measures were increased to 4.38 +/- 0.21 microliters/min/g liver and 338.2 +/- 16.3 nmol/min/g liver, respectively, in rats treated with 500 micrograms/day oPRL.(ABSTRACT TRUNCATED AT 250 WORDS)

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 261, Issue 2
1 May 1992
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Prolactin regulates maternal bile secretory function post partum.
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Abstract

Prolactin regulates maternal bile secretory function post partum.

Y Liu, J F Hyde and M Vore
Journal of Pharmacology and Experimental Therapeutics May 1, 1992, 261 (2) 560-566;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Abstract

Prolactin regulates maternal bile secretory function post partum.

Y Liu, J F Hyde and M Vore
Journal of Pharmacology and Experimental Therapeutics May 1, 1992, 261 (2) 560-566;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics