Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Abstract

Effect of reserpine on histamine metabolism in the mouse brain.

N Muroi, R Oishi and K Saeki
Journal of Pharmacology and Experimental Therapeutics March 1991, 256 (3) 967-972;
N Muroi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R Oishi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K Saeki
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The effect of reserpine on brain histamine (HA) metabolism in vivo was examined in mice. The level of tele-methylhistamine, a major metabolite of HA, was decreased dose-dependently by reserpine (1-5 mg/kg s.c.), whereas the HA level was unaffected. This effect was observed in all brain regions examined. The accumulation of tele-methylhistamine induced by pargyline (65 mg/kg i.p.), an inhibitor of monoamine oxidase, was inhibited to 19% of the control value 24 hr after the treatment with reserpine (5 mg/kg s.c.). However, the HA decrease induced by (S)-alpha-fluoromethylhistidine (50 mg/kg i.p.) a specific inhibitor of histidine decarboxylase, was not significantly affected by pretreatment with reserpine (5 mg/kg s.c.) 1 or 24 hr before. The HA increase induced by metoprine (10 mg/kg i.p.), an inhibitor of histamine-N-methyltransferase, or by L-histidine (0.5-1.5 g/kg i.p.) was inhibited markedly by pretreatment with reserpine. This effect was more marked when reserpine was administered 1 hr than 24 hr before. In addition, the L-histidine-induced increase in HA level was enhanced markedly by the simultaneous administration of metoprine in the control mice but not in the mice treated with reserpine 1 hr before L-histidine injection. From these results the following are suggested. 1) There may be both of reserpine-resistant and reserpine-sensitive HA pools in histaminergic nerve endings. 2) Most of the neuronal HA in the brain may be located in the former pool. 3) However, the capacity of the former pool may be limited and thus most of the increased HA by L-histidine and metoprine may be transferred into the latter pool.(ABSTRACT TRUNCATED AT 250 WORDS)

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 256, Issue 3
1 Mar 1991
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Effect of reserpine on histamine metabolism in the mouse brain.
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Abstract

Effect of reserpine on histamine metabolism in the mouse brain.

N Muroi, R Oishi and K Saeki
Journal of Pharmacology and Experimental Therapeutics March 1, 1991, 256 (3) 967-972;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Abstract

Effect of reserpine on histamine metabolism in the mouse brain.

N Muroi, R Oishi and K Saeki
Journal of Pharmacology and Experimental Therapeutics March 1, 1991, 256 (3) 967-972;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics