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Abstract

Dipyridamole inhibition of HCO3(-)-Cl- exchange in human erythrocytes.

T A Heming, C G Vanoye and A Bidani
Journal of Pharmacology and Experimental Therapeutics November 1990, 255 (2) 631-635;
T A Heming
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C G Vanoye
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A Bidani
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Abstract

Effects of dipyridamole (DP) on Band 3-mediated HCO3(-)-Cl- exchange were investigated in human red cells at 37 degrees C. The kinetics of net HCO3(-)-Cl- exchange were monitored using a stopped-flow rapid reaction apparatus, under conditions in which HCO3(-)-Cl- exchange was rate-limiting for pH equilibration across the red cell membrane. DP was found to be a rapidly acting, potent inhibitor of HCO3(-)-Cl- exchange, with an apparent I50 of 4 microM. DP produced a mixed competitive-noncompetitive inhibition of HCO3-Cl- exchange. Greater than 50% of the inhibitory effect occurred within 20 msec of DP-red cell interaction, consistent with DP binding to an outward-facing site on the cell membrane. Interaction of red cells with DP was associated with a pH-dependent decrement in the equilibrium Donnan H+ ratio. Because HCO3(-)-Cl- exchange is crucial in vivo for ensuing rapid pH equilibration across the red cell membrane, these effects of DP may have important implications, particularly in the development of high-dose DP regimes for use as an adjunctive agent in cancer chemotherapy.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 255, Issue 2
1 Nov 1990
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Abstract

Dipyridamole inhibition of HCO3(-)-Cl- exchange in human erythrocytes.

T A Heming, C G Vanoye and A Bidani
Journal of Pharmacology and Experimental Therapeutics November 1, 1990, 255 (2) 631-635;

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Abstract

Dipyridamole inhibition of HCO3(-)-Cl- exchange in human erythrocytes.

T A Heming, C G Vanoye and A Bidani
Journal of Pharmacology and Experimental Therapeutics November 1, 1990, 255 (2) 631-635;
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