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Abstract

Prevention and complete reversal of cyclosporine A-induced renal vasoconstriction and nephrotoxicity in the rat by fenoldopam.

D P Brooks, D J Drutz and R R Ruffolo Jr
Journal of Pharmacology and Experimental Therapeutics August 1990, 254 (2) 375-379;
D P Brooks
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D J Drutz
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R R Ruffolo Jr
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Abstract

The primary mechanism of cyclosporine A-induced nephrotoxicity involves renal vasoconstriction. In the present study, we have tested the effects of fenoldopam, a dopamine DA1, receptor agonist with renal vasodilator properties, on the changes in renal function induced by acute and subacute administration of cyclosporine A. In inactin-anesthetized rats, acute administration of cyclosporine A (100 mg/kg i.p.) significantly decreased paraaminohippuric acid (PAH) and inulin clearances. Fenoldopam, at a dose (10 micrograms/kg.min) which alone significantly increased PAH and inulin clearances, completely prevented the cyclosporine A-induced reductions in renal function. Similarly, subacute administration of cyclosporine A (20 mg/kg.day for 3 days) resulted in significant reductions in base-line PAH and inulin clearances which were normalized by administration of fenoldopam. These data indicate that administration of fenoldopam can both prevent and completely reverse cyclosporine A-induced renal vasoconstriction and nephrotoxicity.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 254, Issue 2
1 Aug 1990
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Abstract

Prevention and complete reversal of cyclosporine A-induced renal vasoconstriction and nephrotoxicity in the rat by fenoldopam.

D P Brooks, D J Drutz and R R Ruffolo
Journal of Pharmacology and Experimental Therapeutics August 1, 1990, 254 (2) 375-379;

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Abstract

Prevention and complete reversal of cyclosporine A-induced renal vasoconstriction and nephrotoxicity in the rat by fenoldopam.

D P Brooks, D J Drutz and R R Ruffolo
Journal of Pharmacology and Experimental Therapeutics August 1, 1990, 254 (2) 375-379;
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