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Abstract

Distribution of substance P receptors in rabbit airways, functional and autoradiographic studies.

J Black, L Diment, C Armour, L Alouan and P Johnson
Journal of Pharmacology and Experimental Therapeutics April 1990, 253 (1) 381-386;
J Black
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L Diment
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C Armour
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L Alouan
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P Johnson
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Abstract

We have studied systematically the distribution of receptors for substance P in the airway smooth muscle of the rabbit using both functional studies and light-microscopic autoradiography. Four areas of the respiratory tract were examined: the midtrachea (T1) and proximal, middle and distal portions of the right main bronchus (B1, B2 and B3, respectively). The magnitude of the contractile response to substance P in preparations from six to eight animals was location-dependent, increasing significantly from proximal to distal areas. Maximal tension expressed as a function of tissue weight +/- S.E.M. was 24.8 +/- 3 for T1, 39 +/- 10 for B1, 108 +/- 31 for B2 and 160 +/- 42 for B3. The potency of substance P in B2 and B3 was significantly greater (EC50 = 4.8 x 10(-7) M; 2.8 x 10(-7) M, respectively) than that in T1 (2.5 x 10(-6) M). After inhibition of endogenous enkephalinase by phosphoramidon there was an increase in sensitivity to substance P in both T1 (EC50 = 2.3 x 10(-7) M, n = 5) and B3 (2.6 x 10(-9) M, n = 5). There was remarkable agreement in the results obtained with autoradiography. No binding sites (0) were visualized to Bolton Hunter substance P in T1. Sparse but specific binding (+) was seen in B1, whereas it was marked ( ) in B2 and very dense ( ++) in B3. Thus, our results have shown that receptors for substance P are more numerous in the distal than proximal airways of the rabbit. This may indicate a physiological role for substance P in the regulation of airway smooth muscle tone in the distal airways.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 253, Issue 1
1 Apr 1990
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Abstract

Distribution of substance P receptors in rabbit airways, functional and autoradiographic studies.

J Black, L Diment, C Armour, L Alouan and P Johnson
Journal of Pharmacology and Experimental Therapeutics April 1, 1990, 253 (1) 381-386;

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Abstract

Distribution of substance P receptors in rabbit airways, functional and autoradiographic studies.

J Black, L Diment, C Armour, L Alouan and P Johnson
Journal of Pharmacology and Experimental Therapeutics April 1, 1990, 253 (1) 381-386;
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