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Abstract

Dual effects of cholecystokinin-octapeptide on duodenal motility of urethane-anesthetized rats.

S Giuliani, I T Lippe, C A Maggi and A Meli
Journal of Pharmacology and Experimental Therapeutics March 1990, 252 (3) 1312-1317;
S Giuliani
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I T Lippe
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C A Maggi
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A Meli
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Abstract

Intravenous administration of cholecystokinin octapeptide (CCK-8) to urethane-anesthetized rats produced both inhibitory and excitatory effects on intestinal motility. The inhibitory effect, evident as a transient relaxation or inhibition of distension-induced reflex contractions, was abolished by adrenoreceptor blockade, guanethidine pretreatment or removal of the celiac ganglion complex, but was hexamethonium-and atropine-insensitive. The excitatory action of CCK-8 was atropine- and hexamethonium-sensitive, while being unaffected by guanethidine pretreatment. Ligation experiments indicated that the excitatory effect of CCK-8 originates from a stimulant action on structures in the upper duodenum/pyloric sphincter from which a propagated contraction travels to the distal duodenum. We conclude that i.v. CCK-8 inhibits small intestinal motility by directly activating sympathetic neurons in the celiac ganglion and initiates a propagated form of intestinal motility by stimulating neural elements in the upper part of the small intestine.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 252, Issue 3
1 Mar 1990
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Abstract

Dual effects of cholecystokinin-octapeptide on duodenal motility of urethane-anesthetized rats.

S Giuliani, I T Lippe, C A Maggi and A Meli
Journal of Pharmacology and Experimental Therapeutics March 1, 1990, 252 (3) 1312-1317;

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Abstract

Dual effects of cholecystokinin-octapeptide on duodenal motility of urethane-anesthetized rats.

S Giuliani, I T Lippe, C A Maggi and A Meli
Journal of Pharmacology and Experimental Therapeutics March 1, 1990, 252 (3) 1312-1317;
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