Abstract
In the chick chorioallantoic membrane system heparin plus cortisone caused a marked depression in the rate of collagenous protein biosynthesis in vivo during inhibition of angiogenesis. This suggests that monitoring the rate of collagenous protein biosynthesis in the chick chorioallantoic membrane system can be used as a quantitative method for evaluating angiogenesis inhibitors.
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Antiangiogenic action of heparin plus cortisone is associated with decreased collagenous protein synthesis in the chick chorioallantoic membrane system.
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