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Abstract

Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.

J Bergman, B K Madras, S E Johnson and R D Spealman
Journal of Pharmacology and Experimental Therapeutics October 1989, 251 (1) 150-155;
J Bergman
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B K Madras
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S E Johnson
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R D Spealman
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Abstract

The self-administration of cocaine was compared with that of bupropion, 1-(2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, mazindol, methylphenidate and nomifensine, drugs that displace [3H]cocaine from its binding sites and have monoamine uptake inhibiting effects in common with those of cocaine. Squirrel monkeys responded under a second-order fixed-interval schedule of consequent i.v. drug injection, and dose-effect curves were established by determining stable rates of responding maintained by saline and a range of doses of each drug. Cocaine (0.01-0.56 mg/kg/injection), bupropion (0.1-3.0 mg/kg/injection), 1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3- phenylpropyl)piperazine-(0.03-1.0 mg/kg/injection), methylphenidate (0.01-0.3 mg/kg/injection) and nomifensine (0.01-0.3 mg/kg) maintained comparable rates and patterns of responding in all subjects, whereas mazindol (0.03-0.3 mg/kg) maintained self-administration behavior in only half the monkeys studied. The present results in conjunction with those of previous studies in squirrel monkeys reveal a close correspondence between the relative potencies of cocaine and related drugs for maintaining i.v. self-administration and for increasing rates of schedule-controlled responding, suggesting that the reinforcing and psychomotor-stimulant effects of the drugs are mediated similarly. The potency relations observed in the present study also agree generally with those observed for displacement of specifically bound [3H]cocaine in monkey caudate-putamen suggesting that the reinforcing effects of cocaine involve its actions at specific recognition sites in brain.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 251, Issue 1
1 Oct 1989
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Abstract

Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.

J Bergman, B K Madras, S E Johnson and R D Spealman
Journal of Pharmacology and Experimental Therapeutics October 1, 1989, 251 (1) 150-155;

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Abstract

Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.

J Bergman, B K Madras, S E Johnson and R D Spealman
Journal of Pharmacology and Experimental Therapeutics October 1, 1989, 251 (1) 150-155;
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