Abstract

Following subcutaneous administration, tartrate was eliminated in the urine of cats, dogs, and rabbits in practically the same degree. Up to 88 per cent of the amount injected was recovered. Following oral administration to rabbits and dogs, the proportion recovered was less, and was considerably smaller in the case of rabbits than in the case of dogs. Some experimental evidence supports the probability that these differences are to be ascribed to greater bacterial destruction in the intestine of the rabbit. The excretion of tartrate in animals which developed tolerance, also in those in which cumulative effects were exhibited, was studied.