Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Abstract

Effects of acute and chronic prenatal nicotine treatment on central catecholamine systems of male and female rat fetuses and offspring.

U Ribary and W Lichtensteiger
Journal of Pharmacology and Experimental Therapeutics February 1989, 248 (2) 786-792;
U Ribary
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
W Lichtensteiger
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The effect of acute and chronic prenatal administration of nicotine on central catecholamine systems was studied in Long Evans rats. A single injection of nicotine (1 mg/kg s.c.) to urethane-anesthetized time-pregnant dams at gestational day (GD) 21 increased dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid (determined by radioenzymatic assay and high-performance liquid chromatography with electrochemical detection, respectively) in male and female fetal forebrain within 30 min. No significant change was seen in norepinephrine (NE) and MOPEG, but the MOPEG/NE ratio increased in male fetuses. After the administration of nicotine by an osmotic minipump (0.25 mg/kg x hour or vehicle for controls) between GD 12 and 18/19, MOPEG was elevated at GD 18 and reduced at postnatal day (PN) 15 in both sexes; the reduction persisted in males until adulthood (2.5 months). 3,4-dihydroxyphenylacetic acid was affected by chronic drug treatment only in males with an increase at GD 18 and PN 15 and a decrease in adulthood. In contrast, homovanillic acid was reduced in adult offspring of both sexes. Male NE and dopamine of both sexes was above control level at PN 15. Cross-fostering data demonstrate that the changes were due to prenatal influences. The observations indicate that central fetal catecholamine systems are responsive to acute administration of nicotine and that chronic prenatal exposure to the drug results in persistent alterations in the functional state of these neurons. The drug-induced pattern of neurochemical alterations changes during ontogeny until adulthood; it depends upon the sex of the offspring.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 248, Issue 2
1 Feb 1989
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Effects of acute and chronic prenatal nicotine treatment on central catecholamine systems of male and female rat fetuses and offspring.
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Abstract

Effects of acute and chronic prenatal nicotine treatment on central catecholamine systems of male and female rat fetuses and offspring.

U Ribary and W Lichtensteiger
Journal of Pharmacology and Experimental Therapeutics February 1, 1989, 248 (2) 786-792;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Abstract

Effects of acute and chronic prenatal nicotine treatment on central catecholamine systems of male and female rat fetuses and offspring.

U Ribary and W Lichtensteiger
Journal of Pharmacology and Experimental Therapeutics February 1, 1989, 248 (2) 786-792;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics