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Abstract

Relaxant effect of N-formyl-methionyl-leucyl-phenylalanine on rabbit vascular strips.

C Laplante, B Tremblay and F Marceau
Journal of Pharmacology and Experimental Therapeutics February 1989, 248 (2) 774-780;
C Laplante
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B Tremblay
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F Marceau
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Abstract

Some types of rabbit isolated blood vessels precontracted with phenylephrine relaxed when exposed to the chemotactic peptide N-formyl-Met-Leu-Phe (FMLP). The thoracic aorta was unresponsive whereas the portal vein and pulmonary artery exhibited concentration-dependent relaxing responses to FMLP (1-100 nM). FMLP-induced relaxations developed over several minutes and occurred after a latency of 30 to 40 sec. An inconsistent, brief and small contractile phase preceded the relaxations in some tissues. Stable responses to FMLP could be obtained repeatedly at 1.5-hr intervals. On both the portal vein and the pulmonary artery, the structure-activity relationship of peptides related to FMLP was similar to the one reported for activating phagocytic leukocytes. The peptide Boc-Phe-D-Leu-Phe-D-Leu-Phe behaved as a competitive antagonist of FMLP-induced relaxations with a calculated pA2 of 7.5 on both types of responsive vessels. Indomethacin inhibited the relaxations completely on the pulmonary artery and partially on the portal vein. FMLP-induced vasorelaxations were unaffected by a platelet-activating factor antagonist, BN 52021, or a 5-lipoxygenase inhibitor, L-651,392. Removal of the endothelium did not prevent the relaxant response to FMLP. The release of 6-keto-prostaglandin F1 alpha in the bathing fluid of portal vein and pulmonary artery exposed to FMLP was demonstrated using a radioimmunoassay. FMLP relaxed rabbit vascular strips in a blood-free environment by releasing secondary mediators tentatively identified as prostaglandins; however, a component of the relaxation in the portal vein was not mediated by cyclooxygenase products.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 248, Issue 2
1 Feb 1989
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Abstract

Relaxant effect of N-formyl-methionyl-leucyl-phenylalanine on rabbit vascular strips.

C Laplante, B Tremblay and F Marceau
Journal of Pharmacology and Experimental Therapeutics February 1, 1989, 248 (2) 774-780;

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Abstract

Relaxant effect of N-formyl-methionyl-leucyl-phenylalanine on rabbit vascular strips.

C Laplante, B Tremblay and F Marceau
Journal of Pharmacology and Experimental Therapeutics February 1, 1989, 248 (2) 774-780;
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