Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Abstract

Tertatolol increases glomerular filtration and urinary sodium in anesthetized rats.

G E Plante, C Prévost, P Sirois, C Rochat and J F Prost
Journal of Pharmacology and Experimental Therapeutics February 1989, 248 (2) 741-746;
G E Plante
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C Prévost
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P Sirois
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C Rochat
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J F Prost
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Tertatolol is a new beta-adrenergic blocking agent that possesses unique actions on kidney function. In the present study, the effect of increasing doses of tertatolol (0.025, 0.05, 0.1, 0.2 and 0.3 mg) was examined in different groups of anesthetized rats and the results compared with injection of the vehicle. Bolus i.v. injections of tertatolol resulted in a dose-related elevation of urine volume (UV), from 4.1 +/- 0.3 to 6.0 +/- 0.4, 10.2 +/- 1.3, 13.8 +/- 1.2, 18.8 +/- 1.9 and 16.4 +/- 1.8 microliters/min, respectively. Similarly, urine Na increased from 0.4 +/- 0.1 to 0.8 +/- 0.2, 1.2 +/- 0.2, 2.2 +/- 0.3, 3.4 +/- 0.7 and 2.9 +/- 0.6 mueq/min. These changes were associated with a progressive rise in glomerular filtration rate (GFR) from a mean control value of 1.15 +/- 0.10 to 1.28 +/- 0.09, 1.41 +/- 0.07, 1.50 +/- 0.10, 1.62 +/- 0.16 and 1.48 +/- 0.07 ml/min. No change in urinary phosphate excretion was observed. In a separate group of studies, the effect of tertatolol was compared with propranolol (1 mg): the maximal elevation on UV and urine Na was less than 25% of that obtained with tertatolol. Elevation of GFR was also 30% higher in animals receiving tertatolol. The effect of tertatolol on UV and urine Na resulted in part from the rise in GFR but also from tubular inhibition of Na transport, since fractional Na excretion increased from 0.24 +/- 0.09 to a maximal value of 1.76 +/- 0.10%. This tubular action presumably occurs beyond the proximal nephron, because no effect on urinary phosphate excretion was obtained during tertatolol.(ABSTRACT TRUNCATED AT 250 WORDS)

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 248, Issue 2
1 Feb 1989
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Tertatolol increases glomerular filtration and urinary sodium in anesthetized rats.
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Abstract

Tertatolol increases glomerular filtration and urinary sodium in anesthetized rats.

G E Plante, C Prévost, P Sirois, C Rochat and J F Prost
Journal of Pharmacology and Experimental Therapeutics February 1, 1989, 248 (2) 741-746;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Abstract

Tertatolol increases glomerular filtration and urinary sodium in anesthetized rats.

G E Plante, C Prévost, P Sirois, C Rochat and J F Prost
Journal of Pharmacology and Experimental Therapeutics February 1, 1989, 248 (2) 741-746;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics