Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Abstract

Pharmacological analysis of nicotinic relaxation of bovine retractor penis muscle.

E Klinge, S Alaranta and N O Sjöstrand
Journal of Pharmacology and Experimental Therapeutics April 1988, 245 (1) 280-286;
E Klinge
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S Alaranta
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
N O Sjöstrand
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Relaxations of the isolated bovine retractor penis muscle elicited by nicotine and the three other nicotinic agonists acetylcholine, carbachol, and dimethylphenylpiperazinium were studied. Nicotine (10-45 microM) induced dose-dependent relaxations that closely resembled those evoked by transmural stimulation of inhibitory nerves. The relaxations induced by this dose level of nicotine were abruptly abolished by hypoxia and totally blocked by 1.2 microM mecamylamine, 45 microM lidocaine, and 13 microM methylene blue. They were reduced 50-90% by 0.16 microM tetrodotoxin, but they were unaffected by 17 microM scopolamine. Provided that sufficient concentrations of scopolamine and eserine were present, the relaxations caused by acetylcholine (30-140 microM) were exactly like those evoked by nicotine, and they were identically affected by hypoxia and the blocking drugs. Also carbachol and dimethylphenylpiperazinium induced relaxations qualitatively identical to those effected by the above-mentioned doses of nicotine. Relaxations induced by larger doses of nicotine were less susceptible to hypoxia and the blocking drugs. The results suggest that nicotine concentrations ranging from about 10-45 microM relax the bovine retractor penis muscle by a rather selective activation of inhibitory nerves, whereas higher concentrations may additionally activate some other less specific inhibitory mechanism. They further strongly suggest the presence of nerve cell bodies in this muscle. It is suggested that one physiological role of acetylcholine in the development of penile erection is nicotinic activation of inhibitory nerves. Moreover, nicotinic activation of these nerves of the bovine retractor penis muscle can be used as a model for further characterization of mammalian erectile nerves.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 245, Issue 1
1 Apr 1988
  • Table of Contents
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Pharmacological analysis of nicotinic relaxation of bovine retractor penis muscle.
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Abstract

Pharmacological analysis of nicotinic relaxation of bovine retractor penis muscle.

E Klinge, S Alaranta and N O Sjöstrand
Journal of Pharmacology and Experimental Therapeutics April 1, 1988, 245 (1) 280-286;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Abstract

Pharmacological analysis of nicotinic relaxation of bovine retractor penis muscle.

E Klinge, S Alaranta and N O Sjöstrand
Journal of Pharmacology and Experimental Therapeutics April 1, 1988, 245 (1) 280-286;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics