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Journal of Pharmacology and Experimental Therapeutics

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Abstract

Adenosine inhibits immunoglobulin E-dependent histamine secretion from human basophil leukocytes by two independent mechanisms.

P J Hughes, R C Benyon and M K Church
Journal of Pharmacology and Experimental Therapeutics September 1987, 242 (3) 1064-1070;
P J Hughes
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R C Benyon
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M K Church
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Abstract

Adenosine inhibits immunoglobulin E-dependent histamine release when preincubated with human basophil leukocytes before challenge. Two distinct mechanisms for this inhibition have been demonstrated. The first we suggest to be an A2-purinoceptor mediated mechanism. This effect, which is apparent with both 15- and 60-min preincubation periods, is mimicked by 5'-N-ethylcarboxamideadenosine, blocked by 8-phenyltheophylline but not dipyridamole and is associated with the ability of adenosine to elevate cyclic AMP. The second, which is mimicked by 3-deazaadenosine and is associated only with the longer 60-min preincubation period, is reversed by dipyridamole but not by 8-phenyltheophylline suggesting it to be an intracellular mechanism. Its enhancement by homocysteine thiolactone and reversal by exogenous S-adenosyl methionine suggests it to result from increasing intracellular S-adenosyl homocysteine levels. Our failure to detect increased 3H-methyl incorporation into chloroform-methanol extractable lipids after immunoglobulin E-dependent activation would indicate that inhibition of S-adenosyl methionine methylation reactions are an unlikely mechanism. As both prior stimulation of A2-purinoceptors and elevation of intracellular S-adenosyl homocysteine enhance and prolong the cyclic AMP response consequent upon immunoglobulin E-dependent activation, this represents a common mechanism by which histamine release may be suppressed.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 242, Issue 3
1 Sep 1987
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Abstract

Adenosine inhibits immunoglobulin E-dependent histamine secretion from human basophil leukocytes by two independent mechanisms.

P J Hughes, R C Benyon and M K Church
Journal of Pharmacology and Experimental Therapeutics September 1, 1987, 242 (3) 1064-1070;

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Abstract

Adenosine inhibits immunoglobulin E-dependent histamine secretion from human basophil leukocytes by two independent mechanisms.

P J Hughes, R C Benyon and M K Church
Journal of Pharmacology and Experimental Therapeutics September 1, 1987, 242 (3) 1064-1070;
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