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Abstract

Effects of the serotonin antagonists, cyproheptadine, ketanserin and mianserin, on cyclic flow reductions in stenosed canine coronary arteries.

L R Bush
Journal of Pharmacology and Experimental Therapeutics February 1987, 240 (2) 674-682;
L R Bush
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Abstract

We compared the abilities of three pharmacologically and structurally dissimilar 5-hydroxytryptamine (5-HT2) antagonists, cyproheptadine, ketanserin, and mianserin, to interrupt cyclic flow reductions (CFRs) in stenosed coronary arteries of open-chest dogs. All three drugs decreased the frequency and severity of CFRs, but differed in the doses required for total abolition. Cyproheptadine and ketanserin both reduced by approximately 50% the frequency of CFRs at 10 micrograms/kg i.v. Mianserin appeared to be less potent; an approximately 50% reduction of the frequency of CFRs required 100 micrograms/kg. These in vivo results correlated well with their abilities to inhibit epinephrine plus 5-HT-induced aggregation of canine platelet-rich plasma in vitro. The IC50 values for inhibition of aggregation stimulated by this combination of agonists were 2.21, 2.84 and 7.38 microM, respectively. Ketanserin also inhibited amplification by 5-HT of ADP-induced aggregation of canine platelets much more potently than mianserin (IC50 = 0.07 vs. 3.18 microM). Mianserin and RX 781094, a selective alpha-2 adrenoceptor antagonist, inhibited epinephrine-stimulated aggregation of human platelets more potently than ketanserin (IC50 values = 6.10, 0.19 and greater than 10 microM, respectively). Thus, the abilities of three 5-HT2 antagonists with diverse chemical structures and pharmacologic profiles (5-HT2 antagonism notwithstanding) to abolish CFRs suggests that amplification by 5-HT of other mediators, e.g. epinephrine and/or ADP, influences coronary blood flow importantly in this model.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 240, Issue 2
1 Feb 1987
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Abstract

Effects of the serotonin antagonists, cyproheptadine, ketanserin and mianserin, on cyclic flow reductions in stenosed canine coronary arteries.

L R Bush
Journal of Pharmacology and Experimental Therapeutics February 1, 1987, 240 (2) 674-682;

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Abstract

Effects of the serotonin antagonists, cyproheptadine, ketanserin and mianserin, on cyclic flow reductions in stenosed canine coronary arteries.

L R Bush
Journal of Pharmacology and Experimental Therapeutics February 1, 1987, 240 (2) 674-682;
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