Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Abstract

Analysis of airway responses to A23187 in the cat.

T Kriseman, D C Underwood, A L Hyman and P J Kadowitz
Journal of Pharmacology and Experimental Therapeutics November 1986, 239 (2) 395-399;
T Kriseman
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D C Underwood
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A L Hyman
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P J Kadowitz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Airway responses to ionophore A23187 were investigated in anesthetized, paralyzed cats under conditions of controlled ventilation. Intravenous injections of A23187 caused dose-related increases in transpulmonary pressure and lung resistance and dose-related decreases in dynamic compliance and aortic pressure. Airway responses to A23187 were reduced by sodium meclofenamate, a cyclooxygenase inhibitor, in a dose that decreased bronchomotor responses to the prostaglandin precursor, arachidonic acid. The cyclooxygenase inhibitor had no significant effect on airway responses to U-46619, a prostaglandin endoperoxide analog whose actions mimic those of thromboxane A2. Bronchomotor responses to ionophore A23187 were also reduced by SQ 29,548, a thromboxane receptor antagonist. SQ 29,548 reduced airway responses to the thromboxane A2 mimic, U-46619, but had no significant effect on airway responses to prostaglandins D2 or F2 alpha. These data indicate that ionophore A23187 constricts smooth muscle in central airways and in peripheral portions of the lung. In addition, these results suggest that in the closed-chest cat, bronchoconstrictor responses to A23187 are mediated mainly by formation of cyclooxygenase products and that a substantial part of the response is due to thromboxane A2 formation.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 239, Issue 2
1 Nov 1986
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Analysis of airway responses to A23187 in the cat.
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Abstract

Analysis of airway responses to A23187 in the cat.

T Kriseman, D C Underwood, A L Hyman and P J Kadowitz
Journal of Pharmacology and Experimental Therapeutics November 1, 1986, 239 (2) 395-399;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Abstract

Analysis of airway responses to A23187 in the cat.

T Kriseman, D C Underwood, A L Hyman and P J Kadowitz
Journal of Pharmacology and Experimental Therapeutics November 1, 1986, 239 (2) 395-399;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

Similar Articles

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics