Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Abstract

Taurocholate and steroid glucuronides: mutual protection against cholestasis in the isolated perfused rat liver.

S Durham and M Vore
Journal of Pharmacology and Experimental Therapeutics May 1986, 237 (2) 490-495;
S Durham
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M Vore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Estradiol-17 beta-(beta-D-glucuronide) (E217G) was shown to be cholestatic in the isolated perfused female rat liver. Doses of 0.85, 1.3, 1.7 and 2.1 mumol decreased bile flow maximally at 15 to 30 min by 29, 37, 68 and 76% respectively. Approximately 95% of a dose of [3H]E217G was cleared from the perfusate in 30 min and was secreted in bile, with 93, 85, 71 and 55% of the dose appearing in bile within 120 min after doses of 0.85, 1.3, 1.7 and 2.1 mumol, respectively. Neither vehicle nor 1.7 mumol of estradiol-3-(beta-D-glucuronide) (E23G) significantly altered bile flow. Infusion of taurocholate at 40 and 60 mumol/hr, respectively, partially and completely protected against the cholestasis induced by 1.7 mumol of E217G. The log dose-response curve for E217G-induced cholestasis was much steeper and was shifted to the right in the presence of a 60 mumol/hr infusion of taurocholate. Infusion of taurocholate at 80 mumol/hr in the absence of E217G or E23G decreased bile flow by 79%. However, addition of 1.7 mumol of either E217G or E23G offered marked protection against taurocholate-induced cholestasis and increased bile acid secretion. Higher doses (3.4 mumol) of E217G or E23G further increased bile flow and bile acid secretion. A model system is presented to explain the mutual protection against cholestasis.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 237, Issue 2
1 May 1986
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Taurocholate and steroid glucuronides: mutual protection against cholestasis in the isolated perfused rat liver.
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Abstract

Taurocholate and steroid glucuronides: mutual protection against cholestasis in the isolated perfused rat liver.

S Durham and M Vore
Journal of Pharmacology and Experimental Therapeutics May 1, 1986, 237 (2) 490-495;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Abstract

Taurocholate and steroid glucuronides: mutual protection against cholestasis in the isolated perfused rat liver.

S Durham and M Vore
Journal of Pharmacology and Experimental Therapeutics May 1, 1986, 237 (2) 490-495;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics