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Abstract

Continuous intraperitoneal infusion of pentobarbital: a model of barbiturate dependence in the rat.

G J Yutrzenka, G A Patrick and W Rosenberger
Journal of Pharmacology and Experimental Therapeutics January 1985, 232 (1) 111-118;
G J Yutrzenka
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G A Patrick
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W Rosenberger
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Abstract

The i.p. administration of pentobarbital using an escalating drug-dose schedule for an 11-day period resulted in the establishment of dependence on pentobarbital in male rats. Mean plasma pentobarbital levels were approximately 5 micrograms/ml during the first 3 days of the infusion period. Subsequently, there was observed a dose-responsive increase in plasma pentobarbital levels for the next 5 days, with a decline in pentobarbital levels noted during the final 3 days of the pentobarbital infusion period. Removal of pentobarbital from the infusate resulted in a rapid decline in plasma levels to less than 50% by 8 hr into the drug-free period and to barely detectable levels by 24 hr. This was correlated with a steadily increasing occurrence of withdrawal signs, with a peak occurrence by 7 to 9 hr after initiation of the drug-free period. Spontaneous locomotor activity was significantly greater in pentobarbital-dosed animals during withdrawal than in saline-infused control rats. The i.p. infusion of pentobarbital is a quick and reliable method for the study of barbiturate dependence in the rat.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 232, Issue 1
1 Jan 1985
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Abstract

Continuous intraperitoneal infusion of pentobarbital: a model of barbiturate dependence in the rat.

G J Yutrzenka, G A Patrick and W Rosenberger
Journal of Pharmacology and Experimental Therapeutics January 1, 1985, 232 (1) 111-118;

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Abstract

Continuous intraperitoneal infusion of pentobarbital: a model of barbiturate dependence in the rat.

G J Yutrzenka, G A Patrick and W Rosenberger
Journal of Pharmacology and Experimental Therapeutics January 1, 1985, 232 (1) 111-118;
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