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Abstract

Direct effect of parathyroid hormone on rat uterine contraction.

R L Shew, J A Yee and P K Pang
Journal of Pharmacology and Experimental Therapeutics July 1984, 230 (1) 1-6;
R L Shew
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J A Yee
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P K Pang
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Abstract

Synthetic bovine parathyroid hormone containing the 1-34 NH2 terminal amino acids [bPTH-(1-34)] is capable of inhibiting stimulated uterine contraction. The purpose of the present investigation is to determine whether the inhibitory action of bPTH-(1-34) is a direct action of the hormone fragment. The effect of different synthetic preparations of bPTH-(1-34), salmon calcitonin, corticotropin-inhibiting peptide and bovine serum albumin on oxytocin-stimulated uterine contraction was determined. In addition, the effects of atropine, propranolol, phentolamine, pyrilamine, cimetidine and the prostaglandin synthetase inhibitor indomethacin on the inhibitory action of bPTH-(1-34) on uterine contraction was determined. Both synthetic preparations of bPTH-(1-34) inhibited oxytocin-initiated contractions similarly. Salmon calcitonin, corticotropin-inhibiting peptide, and bovine serum albumin did not alter oxytocin-stimulated uterine contractions. The salmon calcitonin also did not alter the ability of bPTH-(1-34) to exert its inhibitory effect on uterine contraction. Cholinergic, alpha and beta adrenergic, histaminergic (H1 and H2) and prostaglandin synthetase inhibitors did not alter the action of bPTH-(1-34). These results suggest that the action of bPTH-(1-34) is 1) not due to the presence of a contaminant in the synthetic hormone preparation and 2) that the effect could be due to a direct action effect of the hormone fragment on uterine tissue.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 230, Issue 1
1 Jul 1984
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Abstract

Direct effect of parathyroid hormone on rat uterine contraction.

R L Shew, J A Yee and P K Pang
Journal of Pharmacology and Experimental Therapeutics July 1, 1984, 230 (1) 1-6;

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Abstract

Direct effect of parathyroid hormone on rat uterine contraction.

R L Shew, J A Yee and P K Pang
Journal of Pharmacology and Experimental Therapeutics July 1, 1984, 230 (1) 1-6;
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