Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Abstract

Mechanisms behind the biphasic contractile response to potassium depolarization in isolated rat cerebral arteries.

E D Högestätt and K E Andersson
Journal of Pharmacology and Experimental Therapeutics January 1984, 228 (1) 187-195;
E D Högestätt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K E Andersson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Ring segments of rat basilar and middle cerebral arteries were suspended in a small volume muscle bath and the mechanical activity recorded "isometrically." K+ excess (124 mM) evoked a biphasic contractile response, composed of an early rapid phase (phase A) and an ensuing slow phase (phase B), separated by a small transient relaxation. Cooling produced a gradual dissociation of the two contraction components and depressed their maxima. Readdition of Ca++ to arteries previously depolarized by K+ in the absence of external Ca++ also elicited a biphasic contraction, which excludes the possibility that the initial transient response was initiated by a burst of spikes. Ca++ removal considerably suppressed and 1 mM La abolished both components of the K+ contraction. Prolonged treatment (greater than 3 hr) in Ca++-free, ethylene glycol bis(beta-aminoethyl ether)N,N'-tetraacetic acid (1 mM)-containing medium reduced neither the amplitude of phase A nor that of phase B of the contraction induced by the simultaneous addition of K+ and Ca++. This indicates that the early rapid component was not due to a release of intracellularly stored Ca++. Nifedipine preferentially inhibited phase B of the K+ contraction. The drug also effectively suppressed Ca++-induced contractions in arteries previously depolarized by K+ in Ca++-free medium. The inhibition produced by nifedipine consisted of a reduction of both the maximum and the slope of the concentration-response curve for Ca++. The results of the present study indicate that K+ initiates contraction in rat cerebral arteries by promoting the movement of extracellular and/or superficially bound Ca++ to the cytoplasmic matrix.(ABSTRACT TRUNCATED AT 250 WORDS)

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 228, Issue 1
1 Jan 1984
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Mechanisms behind the biphasic contractile response to potassium depolarization in isolated rat cerebral arteries.
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Abstract

Mechanisms behind the biphasic contractile response to potassium depolarization in isolated rat cerebral arteries.

E D Högestätt and K E Andersson
Journal of Pharmacology and Experimental Therapeutics January 1, 1984, 228 (1) 187-195;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Abstract

Mechanisms behind the biphasic contractile response to potassium depolarization in isolated rat cerebral arteries.

E D Högestätt and K E Andersson
Journal of Pharmacology and Experimental Therapeutics January 1, 1984, 228 (1) 187-195;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics