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Journal of Pharmacology and Experimental Therapeutics

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Abstract

Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA).

R J Fanelli and J O McNamara
Journal of Pharmacology and Experimental Therapeutics July 1983, 226 (1) 147-150;
R J Fanelli
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J O McNamara
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Abstract

Repeated kindled seizures result in increased numbers of benzodiazepine receptors in fascia dentata membranes. Our previous work localized these receptors to a discrete neuronal population, the dentate granule cells. The present investigation characterizes the regulation of this binding by NaCl, pentobarbital and gamma-aminobutyric acid (GABA). [3H]Flunitrazepam binding in membranes from kindled rats exceeded that from controls by 24%. NaCl increased this binding in membranes prepared from control and kindled animals by roughly equivalent amounts (18 and 14%, respectively). No significant differences were found in the effects of pentobarbital on benzodiazepine binding between kindled and control groups. In contrast, addition of GABA increased benzodiazepine binding by a significantly smaller percentage in the kindled (116 +/- 5%) compared to the control (138 +/- 11%) group. We propose that this altered molecular response to GABA is intimately related to the enhanced GABA-mediated inhibition of granule cells present after kindled seizures.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 226, Issue 1
1 Jul 1983
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Abstract

Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA).

R J Fanelli and J O McNamara
Journal of Pharmacology and Experimental Therapeutics July 1, 1983, 226 (1) 147-150;

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Abstract

Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA).

R J Fanelli and J O McNamara
Journal of Pharmacology and Experimental Therapeutics July 1, 1983, 226 (1) 147-150;
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