Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Abstract

Ketamine and the guinea-pig ileum: possible opiate agonist and antagonist actions and effects of peptidase inhibition.

H J Little, K L Alexander, M F Gargan and A L Widdison
Journal of Pharmacology and Experimental Therapeutics April 1983, 225 (1) 206-212;
H J Little
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K L Alexander
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M F Gargan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A L Widdison
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The effects of ketamine and its interaction with naloxone were studied on the transmurally stimulated guinea-pig ileum preparation. Ketamine (at concentrations between 10(-4) and 10(-3) M) depressed the contractions of the ileum, showing a very steep log concentration-effect curve. Naloxone partially reversed the depressant effect of ketamine at slightly higher concentrations (between 10 nM and 1 microM) than those normally required to reverse opiate depression in this tissue. Naloxone did not affect pentobarbitone-induced depression, suggesting that ketamine has specific actions on opiate transmission. Phentolamine and propranolol did not affect the ketamine-induced depression, whereas acetylcholinesterase inhibition did not alter the action of naloxone on this depression. Ketamine showed some reversal effect on the depressant action of morphine and caused contractions of the morphine-tolerant ileum, suggesting that it may have opiate antagonist activity. Inhibition of peptidase enzymes by a mixture of dipeptides potentiated the depression after high-frequency stimulation of the ileum, but did not affect the action of ketamine. The results suggest that ketamine may interact with opiate mechanisms in the ileum to produce part of its depressant action and may also have some opiate antagonist activity.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 225, Issue 1
1 Apr 1983
  • Table of Contents
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Ketamine and the guinea-pig ileum: possible opiate agonist and antagonist actions and effects of peptidase inhibition.
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Abstract

Ketamine and the guinea-pig ileum: possible opiate agonist and antagonist actions and effects of peptidase inhibition.

H J Little, K L Alexander, M F Gargan and A L Widdison
Journal of Pharmacology and Experimental Therapeutics April 1, 1983, 225 (1) 206-212;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Abstract

Ketamine and the guinea-pig ileum: possible opiate agonist and antagonist actions and effects of peptidase inhibition.

H J Little, K L Alexander, M F Gargan and A L Widdison
Journal of Pharmacology and Experimental Therapeutics April 1, 1983, 225 (1) 206-212;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics