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Abstract

Hepatic glutathione and hepatotoxicity: changes induced by selected narcotics.

R C James, D R Goodman and R D Harbison
Journal of Pharmacology and Experimental Therapeutics June 1982, 221 (3) 708-714;
R C James
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D R Goodman
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R D Harbison
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Abstract

Propoxyphene and morphine lowered hepatic glutathione and increased serum glutamic-pyruvic transaminase (SGPT) activity when administered to male mice. Maximal changes were seen at 3 to 6 hr after administration, but the effects lasted for as long as 18 hr. Morphine-induced hepatic changes potentiated both acetaminophen and cocaine-induced hepatotoxicity. Naltrexone, a narcotic antagonist, abolished the glutathione depletion produced by both propoxyphene and morphine, but did not alter the propoxyphene-induced elevations of SGPT. Naltrexone also was tested against other narcotic agonists we have previously demonstrated to be hepatotoxic. Naltrexone pretreatment of antagonized L-alpha-acetylmethadol (LAAM)-induced depletion of glutathione and elevations of SGPT. Similarly, naltrexone antagonized norLAAM-induced depletion of glutathione and elevations of SGPT, but only lessened the magnitude of the changes induced by SKF525-A. The narcotic agonists morphine, LAAM, norLAAM and propoxyphene lower hepatic glutathione and induce hepatocellular damage, but these two effects appear to be unrelated.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 221, Issue 3
1 Jun 1982
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Abstract

Hepatic glutathione and hepatotoxicity: changes induced by selected narcotics.

R C James, D R Goodman and R D Harbison
Journal of Pharmacology and Experimental Therapeutics June 1, 1982, 221 (3) 708-714;

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Abstract

Hepatic glutathione and hepatotoxicity: changes induced by selected narcotics.

R C James, D R Goodman and R D Harbison
Journal of Pharmacology and Experimental Therapeutics June 1, 1982, 221 (3) 708-714;
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