Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Abstract

Mechanisms of the natriuretic and diuretic effects of prostaglandin F2 alpha.

T E Zook and J W Strandhoy
Journal of Pharmacology and Experimental Therapeutics June 1981, 217 (3) 674-680;
T E Zook
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J W Strandhoy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The effects of prostaglandin F2 alpha on renal function were studied in hydropenic dogs. Peak responses occurred in 45 to 60 min. PGF 2 alpha (0.3 microgram.kg-1.min-1) increased urine flow by 1.3 +/- 0.3 ml/min and increased sodium excretion by 27.1 +/- 4.6 microEq/min. Papillary nonurea solute concentration was decreased from 981 +/- 153 to 347 +/- 58 mOsm/kg of H2O and the corticomedullary urea gradient was abolished. Although renal blood flow, glomerular filtration rate, peritubule capillary hydrostatic pressure and renal venous pressure were not changed by PGF2 alpha, urine from the infused kidney became distinctly hypotonic. A "washout" of medullary solutes was not supported by the data since the volume of distribution of 125I-albumin, an index of papillary perfusion rate, was not changed by PGF2 alpha. The contribution of decreased salt reabsorption from Henle's loop was evaluated in dogs that received furosemide and produced essentially isotonic urine. Subsequent intrarenal PGF2 alpha, increased CH2O and produced hypotonic urine with no significant further change in UNaV. These studies suggest that inhibition by PGF2 alpha of salt reabsorption from the thick ascending limb of Henle's loop may account for the modest natriuretic effect and contribute to the dissipation of the nonurea solute gradient. Additionally, there is an inhibition of both vasopressin-mediated water and urea reabsorption which contributed to the diuretic and hyposthenuric effects of infused prostaglandins.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 217, Issue 3
1 Jun 1981
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Mechanisms of the natriuretic and diuretic effects of prostaglandin F2 alpha.
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Abstract

Mechanisms of the natriuretic and diuretic effects of prostaglandin F2 alpha.

T E Zook and J W Strandhoy
Journal of Pharmacology and Experimental Therapeutics June 1, 1981, 217 (3) 674-680;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Abstract

Mechanisms of the natriuretic and diuretic effects of prostaglandin F2 alpha.

T E Zook and J W Strandhoy
Journal of Pharmacology and Experimental Therapeutics June 1, 1981, 217 (3) 674-680;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics