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Abstract

Unimpaired beta adrenergic responses during prazosin administration.

L A Buzzeo, J M Steele Jr and J Lowenstein
Journal of Pharmacology and Experimental Therapeutics November 1979, 211 (2) 345-349;
L A Buzzeo
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J M Steele Jr
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J Lowenstein
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Abstract

We have examined insulin-induced hypoglycemia to determine whether prazosin inhibits the response to sympathetic stimulation, either centrally or at beta adrenergic receptors. Nine patients with essential hypertension were studied during administration of prazosin, hydralazine or placebo. Plasma renin activity increased significantly with hydralazine and was unchanged during prazosin administration. In response to insulin, blood glucose decreased equally with both drugs and placebo, and small increases in dopamine beta-hydroxylase occurred. Plasma renin activity and heart rate increased during hypoglycemia; the increases were greater in patients taking prazosin or hydralazine. The unimpaired responses of plasma dopamine beta-hydroxylase, renin activity and heart rate to insulin-induced hypoglycemia provide evidence that prazosin does not block either the sympathetic discharge elicited by central stimulation (hypoglycemia) or the responses mediated through beta adrenergic receptors.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 211, Issue 2
1 Nov 1979
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Abstract

Unimpaired beta adrenergic responses during prazosin administration.

L A Buzzeo, J M Steele and J Lowenstein
Journal of Pharmacology and Experimental Therapeutics November 1, 1979, 211 (2) 345-349;

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Abstract

Unimpaired beta adrenergic responses during prazosin administration.

L A Buzzeo, J M Steele and J Lowenstein
Journal of Pharmacology and Experimental Therapeutics November 1, 1979, 211 (2) 345-349;
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