Abstract

Using the hypertransfused rat as a model, we have identified 2,3-dihydroxyhenzoic acid (2,3-DHB) as an orally effective iron-chelating agent. The iron excreted in response tc 2,3-DHB is excreted via the urine. The amount of iron excreted is a function of both the dose and time course of the drug administration. The chelation is specific for iron; there were no changes in the amounts of urinary calcium, magnesium, copper or zinc. The oral administration of 2,3-DHB decreased time absorption of iron (⁵⁹FeCl₃,) by the gut even when a physiological amount of iron was added. The LD5O of 2,3-DHB is greater than 3 g/kg in the rabbit. Rats and mice administered up to 600 mg/kg chronically have shown no signs of toxicity.