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Research ArticleArticle

N-GLUCOSIDE FORMATION AS A DETOXIFICATION MECHANISM IN MAMMALS

D. E. Duggan, J. J. Baldwin, B. H. Arison and R. E. Rhodes
Journal of Pharmacology and Experimental Therapeutics September 1974, 190 (3) 563-569;
D. E. Duggan
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J. J. Baldwin
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B. H. Arison
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R. E. Rhodes
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This article has a correction. Please see:

  • ERRATA - January 01, 1975

Abstract

After intravenous dosage in dogs, the major portion of the xanthine oxidase inhibitor, 3-(4-pyrimidinyl)-5-(4-pynidyl)-1,2,4-triazole, is excreted in bile as a polar conjugate refractory to µ-glucuronidase, sulfatase, µ-glycosidase and nucleoside phosphorylase. High resolution mass spectrometry. nuclear magnetic resonance, absorption and fluorescence spectra, and identification of chemical hydrolysis produets of recrystallized conjugate have established its structure as the N-(1)-µ-D-glucopyranoside. The same conjugate is a sigificant component of renal and biliary elimination in the rat and monkey as well. These constitute the first reported instance of N-glucosylation as a detoxification mechanism in mammals.

Footnotes

    • Received February 26, 1974.
    • Accepted May 21, 1974.
  • © 1974 by The Williams & Wilkins Co.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 190, Issue 3
1 Sep 1974
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Research ArticleArticle

N-GLUCOSIDE FORMATION AS A DETOXIFICATION MECHANISM IN MAMMALS

D. E. Duggan, J. J. Baldwin, B. H. Arison and R. E. Rhodes
Journal of Pharmacology and Experimental Therapeutics September 1, 1974, 190 (3) 563-569;

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Research ArticleArticle

N-GLUCOSIDE FORMATION AS A DETOXIFICATION MECHANISM IN MAMMALS

D. E. Duggan, J. J. Baldwin, B. H. Arison and R. E. Rhodes
Journal of Pharmacology and Experimental Therapeutics September 1, 1974, 190 (3) 563-569;
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