Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

DIFFERENTIAL EFFECTS OF FUROSEMIDE AND ETHACRYNIC ACID ON ELECTROLYTE EXCRETION IN ANESTHETIZED DOGS

P. C. Alguire, M. D. Bailie, W. J. Weaver, D. G. Taylor and J. B. Hook
Journal of Pharmacology and Experimental Therapeutics September 1974, 190 (3) 515-522;
P. C. Alguire
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. D. Bailie
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
W. J. Weaver
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. G. Taylor
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. B. Hook
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

This article has a correction. Please see:

  • ERRATA - January 01, 1975

Abstract

Furosemide and ethacrynic acid are the most efficacious diuretics currently available. Even though the chemical structures of these compounds are dissimilar, their pharmacological actions are nearly indistinguishable. While the clinical literature suggests that there is a pharmacological difference between furosemide and ethacrynic acid, this finding has not been demonstrated in animals. In man both drugs produce chloriuresis and plasma volume reduction and both may produce metabolic alkalosis. However, the ability of furosemide to inhibit carbonic anhydrase and increase bicarbonate excretion may make it less likely to produce metabolic alkalosis. In order to demonstrate the pharmacological differences between the two drugs in dogs, the effects of equinatriuretic doses of furosemide and ethacrynic acid on the excretion of bicarbonate, chloride and potassium, on osmolality and on pH were determined. Plasma volume in anesthetized animals was maintained constant by varying the infusion rate of a balanced Tyrode's solution in normal animals and during alkalosis and acidosis. When sodium excretion increased from 1 to 40% of the filtered load, no quantitative differences between the effects of the two diuretics were seen on the excretion of chloride or potassium or on pH. In normal animals. when sodium excretion exceeded 30% of the filtered load, the effect of furosemide on bicarbonate excretion exceeded that of ethacrynic acid. During respiratory alkalosis, the effect of furosemide on bicarbonate excretion was greatly magnified. At 10% of filtered sodium excreted, the effect of furosemide on bicarbonate excretion was significantly greater than that produced by ethacrynic acid and the difference increased with increasing sodium excretion. There was no significant difference in the effect of the drugs in respiratory acidosis or metabolic alkalosis. The significantly greater effect of furosemide on bicarbonate excretion in normal animals and in respiratory alkalosis may help explain the clinical observation that furosemide has a lesser propensity to produce alkalosis than does ethacrynic acid. Furthermore, the data predict that ethacrynic acid would more markedly augment predisposing alkalosis than would furosemide.

Footnotes

    • Received September 12, 1973.
    • Accepted May 7, 1974.
  • © 1974 by The Williams & Wilkins Co.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 190, Issue 3
1 Sep 1974
  • Table of Contents
  • Index by author
  • Back Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
DIFFERENTIAL EFFECTS OF FUROSEMIDE AND ETHACRYNIC ACID ON ELECTROLYTE EXCRETION IN ANESTHETIZED DOGS
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

DIFFERENTIAL EFFECTS OF FUROSEMIDE AND ETHACRYNIC ACID ON ELECTROLYTE EXCRETION IN ANESTHETIZED DOGS

P. C. Alguire, M. D. Bailie, W. J. Weaver, D. G. Taylor and J. B. Hook
Journal of Pharmacology and Experimental Therapeutics September 1, 1974, 190 (3) 515-522;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

DIFFERENTIAL EFFECTS OF FUROSEMIDE AND ETHACRYNIC ACID ON ELECTROLYTE EXCRETION IN ANESTHETIZED DOGS

P. C. Alguire, M. D. Bailie, W. J. Weaver, D. G. Taylor and J. B. Hook
Journal of Pharmacology and Experimental Therapeutics September 1, 1974, 190 (3) 515-522;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • PST3093 Stimulates SERCA2a and Improves Cardiac Function
  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Is Hydroxylamine-Induced Cytotoxicity a Valid Marker for Hypersensitivity Reactions to Sulfamethoxazole in Human Immunodeficiency Virus-Infected Individuals?
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics