Abstract
1. Lithium acetate, lithium benzoate and hexamethylene tetramine, because of the delicate tests for them in the blood, are admirably suited for the determination of the circulation time.
2. An improved technique for the determination of the circulation time is presented.
3. The average circulation time from the marginal ear vein to the opposite marginal ear vein in the rabbit is found to be 4.71 seconds. The average circulation time in the dog from external jugular to external jugular vein is 7.8 seconds. The average reaction time of the respiration to sodium cyanide on injection into the marginal ear vein in rabbits is 3.97. The average reaction time of the respiration to sodium cyanide when injected into the external jugular vein in dogs is 8.66. A determination of the reaction time to sodium cyanide, either in the rabbit or dog, gives a figure which is within one second of the complete circulation time. In the rabbit the reaction time to cyanide is 84 per cent of the complete circulation time. In the dog the reaction time is 111 per cent of the circulation time. The effect of various factors on the circulation time and reaction time are discussed, such as the hour to hour and day to day variation, the relation to body weight, dosage, site of injection, pulse, anesthesia and bleeding.
Footnotes
- Received August 20, 1921.
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