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Research ArticleArticle

THE EFFECT OF STEROID METABOLITES ON THE HEMATOPOJETIC STEM CELL POOL

WILLIAM N. HAIT, DOV GORSHEIN, EMMANUEL C. BESA, JOANNE H. JEPSON and FRANK H. GARDNER
Journal of Pharmacology and Experimental Therapeutics September 1973, 186 (3) 656-661;
WILLIAM N. HAIT
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DOV GORSHEIN
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EMMANUEL C. BESA
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JOANNE H. JEPSON
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FRANK H. GARDNER
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Abstract

This study reports suggestive evidence for the ability of 3β-hydroxy-5β-pregnane-20-one, a steroid metabolite of testosterone, to trigger stem cells to a cell cycle stage responsive to the erythnoid differentiating effects of erythropoietin (ESF). Erythropoiesis was suppressed by the hypenoxic method of ESF suppression, to create an animal sensitive to exogenous enythropoietic stimuli. Mice maintained in hyperoxia were injected daily with the metabolite while controls received diluent injections. A significant elevation in erythropoiesis, as measured by 59Fe incorporation into peripheral red blood cells, was observed in the metabolite-treated group 24, 48 and 72 hours after the initial injection. In another expeniment, mice receiving a single injection of the metabolite during hyperoxia were returned to ambient conditions 18 hours later. The observed erythropoietic response to the subsequent release of endogenous ESF, due to the temporary relative hypoxia of ambient conditions, was significantly higher in the metabolite-treated group than in the diluent-treated controls. The increment in erythropoietic response to the metabolite-, compared to the diluent-treated group, was greater in the posthyperoxic system, when rising titers of ESF are found, than in the hypenoxic system, suggesting that ESF may play a pimysioiogical role in the regulation of metabolite-induced erythropioesis.

Footnotes

    • Received August 3, 1972.
    • Accepted May 10, 1973.
  • © 1973 by The Williams & Wilkins Co.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 186, Issue 3
1 Sep 1973
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Research ArticleArticle

THE EFFECT OF STEROID METABOLITES ON THE HEMATOPOJETIC STEM CELL POOL

WILLIAM N. HAIT, DOV GORSHEIN, EMMANUEL C. BESA, JOANNE H. JEPSON and FRANK H. GARDNER
Journal of Pharmacology and Experimental Therapeutics September 1, 1973, 186 (3) 656-661;

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Research ArticleArticle

THE EFFECT OF STEROID METABOLITES ON THE HEMATOPOJETIC STEM CELL POOL

WILLIAM N. HAIT, DOV GORSHEIN, EMMANUEL C. BESA, JOANNE H. JEPSON and FRANK H. GARDNER
Journal of Pharmacology and Experimental Therapeutics September 1, 1973, 186 (3) 656-661;
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