Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

BILIARY EXCRETION OF CARDIAC GLYCOSIDES

JOHN Q. RUSSELL and CURTIS D. KLAASSEN
Journal of Pharmacology and Experimental Therapeutics September 1973, 186 (3) 455-462;
JOHN Q. RUSSELL
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
CURTIS D. KLAASSEN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The rat was more resistant to the lethal properties of all three glycosides (ouabain, digoxin and digitoxin) than either the rabbit or dog. However, the rat's relative resistance was dependent on the glycoside used. The smallest difference in sensitivity was observed with digitoxin in which the rat was 9 times more resistant than the rabbit and 14 times more resistant than the dog; with digoxin, the rat was 25 times more resistant than the rabbit and 92 times more resistant than the dog; the greatest difference was observed with ouabain in which the rat was 63 times more resistant than the rabbit and 110 times more resistant than the dog. Species differences in the biliary excretion of ouabain were reported in a previous study in which it was demonstrated that rats excreted 55% of the drug into bile over a 12-hour period while both rabbits and dogs excreted less than 5%. In the present study, digoxin was excreted into bile similarly by both rats and rabbits (approximately 60% in 12 hours), while dogs excreted only one-fifth that amount. With digitoxin, relatively minor quantitative differences were observed in biliary excretion in the three species studied (45-70% in 12 hours). In all three species, digoxin and digitoxin were excreted against an apparent bile to plasma concentration gradient, ranging from 10 to 300. These data suggest that 1) digoxin and digitoxin are excreted into the bile by a transport process, 2) no general correlation between the polarity of cardiac glycosides and their biliary excretion exists and 3) the additional resistance of the rat to the lethal properties of ouabain and digoxin over that. observed with digitoxin appears to be partially due to a higher rate of excretion of these two glycosides into the bile.

Footnotes

    • Received December 4, 1972.
    • Accepted May 7, 1973.
  • © 1973 by The Williams & Wilkins Co.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 186, Issue 3
1 Sep 1973
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
BILIARY EXCRETION OF CARDIAC GLYCOSIDES
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

BILIARY EXCRETION OF CARDIAC GLYCOSIDES

JOHN Q. RUSSELL and CURTIS D. KLAASSEN
Journal of Pharmacology and Experimental Therapeutics September 1, 1973, 186 (3) 455-462;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

BILIARY EXCRETION OF CARDIAC GLYCOSIDES

JOHN Q. RUSSELL and CURTIS D. KLAASSEN
Journal of Pharmacology and Experimental Therapeutics September 1, 1973, 186 (3) 455-462;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Antagonist-Induced Reversal of Functional and Structural Measures of Hippocampal Benzodiazepine Tolerance
  • Interaction of Diclofenac and Quinidine in Monkeys: Stimulation of Diclofenac Metabolism
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics