Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • Log out
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • Log out
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

CARDIOVASCULAR EFFECTS OF 2,5-DIMETHOXY-4-METHYLAMPHETAMINE (DOM, STP)

H. C. CHENG, J. P. LONG, C. F. BARFKNECHT and D. E. NICHOLS
Journal of Pharmacology and Experimental Therapeutics August 1973, 186 (2) 345-354;
H. C. CHENG
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. P. LONG
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. F. BARFKNECHT
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. E. NICHOLS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

A single dose of 2,5-dimethoxy-4-methylamphetamine (DOM) (246 µg/kg) produced a pressor response in vagotomized dogs. There was also an increase in pulse pressure. Tachyphylaxis developed rapidly after repeated doses of DOM. Responses to tyramine were not diminished after tachyphylaxis to DOM developed. DOM also enhanced pressor responses to norepinephrine, epinephrine and tyramine. In perfused dog fore limb DOM produced a vasodilation followed by a vasoconstriction. The vasoconstriction produced by DOM was not blocked by phentolamine but was antagonized by methysergide. In isolated superfused vascular strips of dog dorsal metatarsal vein, DOM elicited a muscle contraction which was not blocked by phentolamine or cocaine but was antagonized by cinanserin. It was concluded that DOM had a direct stimulatory effect on serotonin receptors. The vasodilation in the perfused fore limb of the dog induced by DOM was not antagonized by propranolol, atropine, pyrilamine or bulbocapnine. In isolated guinea-pig atria, DOM exhibited an antiicotine action and also blocked the inhibitory effect induced by vagus nerve stimulation.

Footnotes

    • Received July 7, 1972.
    • Accepted April 24, 1973.
  • © 1973 by The Williams & Wilkins Co.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 186, Issue 2
1 Aug 1973
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
CARDIOVASCULAR EFFECTS OF 2,5-DIMETHOXY-4-METHYLAMPHETAMINE (DOM, STP)
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

CARDIOVASCULAR EFFECTS OF 2,5-DIMETHOXY-4-METHYLAMPHETAMINE (DOM, STP)

H. C. CHENG, J. P. LONG, C. F. BARFKNECHT and D. E. NICHOLS
Journal of Pharmacology and Experimental Therapeutics August 1, 1973, 186 (2) 345-354;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

CARDIOVASCULAR EFFECTS OF 2,5-DIMETHOXY-4-METHYLAMPHETAMINE (DOM, STP)

H. C. CHENG, J. P. LONG, C. F. BARFKNECHT and D. E. NICHOLS
Journal of Pharmacology and Experimental Therapeutics August 1, 1973, 186 (2) 345-354;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • PST3093 Stimulates SERCA2a and Improves Cardiac Function
  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Tissue Selectivity of Antidiabetic Agent Nateglinide: Study on Cardiovascular and β-Cell KATP Channels
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics