Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

A STUDY OF THE TRANYLCYPROMINE-MEPERIDINE INTERACTION: EFFECTS OF p-CHLOROPHENYL-ALANINE AND l-5-HYDROXYTRYPTOPHAN

PETER K. GESSNER and ALAN G. SOBLE
Journal of Pharmacology and Experimental Therapeutics August 1973, 186 (2) 276-287;
PETER K. GESSNER
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ALAN G. SOBLE
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Tranylcypromine and meperidine administered four hours apart to mice in a ratio of 3:10 by weight exhibited marked superadditivity of their toxic actions, the LD50 of the combination being only 0.54 of that which would be expected on the basis of their individual toxicities. Pretreatment with p-chlorophenylalanine (100 mg/kg) at 72, 48 and 24 hours before the experiment markedly lowered the mortality of mice receiving tranylcypromine and meperidine in a 3:10 ratio four hours apart but not those receiving either tranyleypromine or meperidine alone. Intertreatment with doses of 5-hydroxytryptophan as low as 5 mg/kg one hour before meperidine administration markedly increased mortality of mice receiving the tranylcypromine-meperidine combination. Thus the toxic response of mice to the tranylcypromine-meperidine combination may be mediated by 5-hydroxytryptamine. Meperidine administration four hours after tranylcypromine resulted in a marked hyperthermic response. This response was significantly augmented if 5-hydroxytryptophan was coadministered with the meperidine. Pretreatment with p-chlorophenylalanine did not prevent the development of a hyperthermic response to meperidine in mice administered tranylcypromine four hours earlier; however, the p-chlorophenylalanine-pretreated mice had generally lower body temperatures than control mice.

Footnotes

    • Received July 6, 1972.
    • Accepted March 19, 1973.
  • © 1973 by The Williams & Wilkins Co.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 186, Issue 2
1 Aug 1973
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
A STUDY OF THE TRANYLCYPROMINE-MEPERIDINE INTERACTION: EFFECTS OF p-CHLOROPHENYL-ALANINE AND l-5-HYDROXYTRYPTOPHAN
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

A STUDY OF THE TRANYLCYPROMINE-MEPERIDINE INTERACTION: EFFECTS OF p-CHLOROPHENYL-ALANINE AND l-5-HYDROXYTRYPTOPHAN

PETER K. GESSNER and ALAN G. SOBLE
Journal of Pharmacology and Experimental Therapeutics August 1, 1973, 186 (2) 276-287;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Research ArticleArticle

A STUDY OF THE TRANYLCYPROMINE-MEPERIDINE INTERACTION: EFFECTS OF p-CHLOROPHENYL-ALANINE AND l-5-HYDROXYTRYPTOPHAN

PETER K. GESSNER and ALAN G. SOBLE
Journal of Pharmacology and Experimental Therapeutics August 1, 1973, 186 (2) 276-287;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Evidence That Melanocortin 4 Receptor Mediates Hemorrhagic Shock Reversal Caused by Melanocortin Peptides
  • Is Hydroxylamine-Induced Cytotoxicity a Valid Marker for Hypersensitivity Reactions to Sulfamethoxazole in Human Immunodeficiency Virus-Infected Individuals?
Show more Article

Similar Articles

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics