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Research ArticleArticle

EFFECT OF ALKALOSIS ON OUABAIN TOXICITY IN THE DOG

DARIO GALMARINI, JUAN FEDERICO CAMPODONICO and ROBERTO DANIEL WENK
Journal of Pharmacology and Experimental Therapeutics July 1973, 186 (1) 199-203;
DARIO GALMARINI
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JUAN FEDERICO CAMPODONICO
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ROBERTO DANIEL WENK
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Abstract

The effect of acute alkalosis induced by either hyperventilation or sodium carbonate on the toxicity of ouabain and the importance of secondary alterations in blood pCO2 and plasma concentrations of sodium, calcium and potassium on this toxicity was studied in dogs. The mean lethal dose of ouabain in groups of dogs which had been 1) hyperventilated, 2) given sodium carbonate by infusion, 3) hyperventilated and given supplemental potassium by infusion and 4) given sodium carbonate plus supplemental potassium was significantly decreased as compared with control dogs. The results indicate that ouabain toxicity is increased by acute alkalosis and this is correlated with the increment in blood pH.

Footnotes

    • Received February 9, 1972.
    • Accepted March 5, 1973.
  • © 1972 by The Williams & Wilkins Co.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 186, Issue 1
1 Jul 1973
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Research ArticleArticle

EFFECT OF ALKALOSIS ON OUABAIN TOXICITY IN THE DOG

DARIO GALMARINI, JUAN FEDERICO CAMPODONICO and ROBERTO DANIEL WENK
Journal of Pharmacology and Experimental Therapeutics July 1, 1973, 186 (1) 199-203;

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Research ArticleArticle

EFFECT OF ALKALOSIS ON OUABAIN TOXICITY IN THE DOG

DARIO GALMARINI, JUAN FEDERICO CAMPODONICO and ROBERTO DANIEL WENK
Journal of Pharmacology and Experimental Therapeutics July 1, 1973, 186 (1) 199-203;
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