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Research ArticleArticle

QUANTITATIVE DETERMINATION OF DIAZEPAM IN BLOOD BY RADIOIMMUNOASSAY

BERNARD PESKAR and SYDNEY SPECTOR
Journal of Pharmacology and Experimental Therapeutics July 1973, 186 (1) 167-172;
BERNARD PESKAR
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SYDNEY SPECTOR
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Abstract

This paper describes the production of two different antibodies against diazepam analogs, one being specific for diazepam and the other one recognizing both diazepam and its N-demethylated metabolite. By using these antisera, a radioimmunoassay was developed capable of detecting 1 ng of diazepam which is linear up to 100 ng. The radioimmunoassay has been applied for the measurement of both diazepam and N-desmethyldiazepam in dried ether extracts of whole human blood. Values were compared with those determined by gas-liquid chromatography and found to be in good agreement. This assay might find application especially when only limited amounts of blood or plasma are available.

Footnotes

    • Received October 27, 1972.
    • Accepted February 28, 1973.
  • © 1972 by The Williams & Wilkins Co.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 186, Issue 1
1 Jul 1973
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Research ArticleArticle

QUANTITATIVE DETERMINATION OF DIAZEPAM IN BLOOD BY RADIOIMMUNOASSAY

BERNARD PESKAR and SYDNEY SPECTOR
Journal of Pharmacology and Experimental Therapeutics July 1, 1973, 186 (1) 167-172;

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Research ArticleArticle

QUANTITATIVE DETERMINATION OF DIAZEPAM IN BLOOD BY RADIOIMMUNOASSAY

BERNARD PESKAR and SYDNEY SPECTOR
Journal of Pharmacology and Experimental Therapeutics July 1, 1973, 186 (1) 167-172;
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